The Syndrome of Alveolar Hypoventilation and Diminished Sensitivity of the Respiratory Center
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TL;DR
In the normal subject, an increment in the partial pressure of carbon dioxide (Pco2) in arterial blood of only a few millimeters of mercury suffices to double or even triple minute and alveolar ventilation.
Abstract
IN the normal subject, an increment in the partial pressure of carbon dioxide (Pco2) in arterial blood of only a few millimeters of mercury suffices to double or even triple minute and alveolar ventilation. However, analysis of this relation in terms of a simple stimulus-response pattern is complicated by several factors: changes in blood pH accompany the changes in blood Pco2; intracellular buffers are interposed between the arterial blood and the respiratory center; and the magnitude of the ventilatory response seems to be conditioned, in some obscure way, by factors such as the level of total-body . . .