Cognitive deficit is related to immune-cell beta-NGF in multiple sclerosis patients
Journal of the Neurological SciencesPublished 9 August 2012
Alicja Kalinowska, Mikołaj A. Pawlak, S. Michalak, Jacek Losy
Citations14
SJR quartileQ1
SJR score1.15
SNIP0.99
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In RRMS beta-NGF is strongly linked to cognitive performance, which makes it an attractive therapeutic target and might play a neuroprotective role in MS, especially in the cognitive domain.
Abstract
In RRMS beta-NGF is strongly linked to cognitive performance, which makes it an attractive therapeutic target. It might play a neuroprotective role in MS, especially in the cognitive domain.
Keywords
Neuroscience
Journal of Biological ChemistryPROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
318,326 Citations1951OliverH. Lowry, NiraJ. Rosebrough +2 more
Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Archives of General PsychiatryAn Inventory for Measuring Depression
38,163 Citations1961Aaron T. Beck
The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
NeuropsychologiaThe assessment and analysis of handedness: The Edinburgh inventory
36,704 Citations1971R. C. Oldfield
An inventory of 20 items with a set of instructions and response- and computational-conventions is proposed and the results obtained from a young adult population numbering some 1100 individuals are reported.
Annals of NeurologyDiagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”
4,989 Citations2005Chris H. Polman, Stephen C. Reingold +12 more
New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease.
Journal of the American Statistical AssociationOn the Kolmogorov-Smirnov Test for Normality with Mean and Variance Unknown
3,252 Citations1967Hubert W. Lilliefors
Journal of the American Statistical AssociationOn the Kolmogorov-Smirnov Test for Normality with Mean and Variance Unknown
3,056 Citations1967Hubert W. Lilliefors
NeurologyCognitive dysfunction in multiple sclerosis.
2,109 Citations1991Stephen M. Rao, Gary J. Leo +2 more
Cognitive impairment in multiple sclerosis patients was not significantly associated with illness duration, depression, disease course, or medication usage, but was significantly (albeit weakly) correlated with physical disability.
Annual Review of NeurosciencePhysiology of the Neurotrophins
1,904 Citations1996Gary R. Lewin, Yves‐Alain Barde
Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.
Proceedings of the National Academy of SciencesHippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
1,421 Citations1995Martin Körte, Patrick Carroll +4 more
It is suggested that BDNF might have a functional role in the expression of LTP in the hippocampus, and the magnitude of the potentiation, as well as the percentage of cases in which LTP could be induced successfully, was clearly affected.
Proceedings of the National Academy of SciencesMolecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.
701 Citations1990Patrik Ernfors, Carlos F. Ibáñez +3 more
A pool of degenerate oligonucleotides representing all possible codons in regions of homology between brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) to prime rat hippocampal cDNAs to represent a family of neurotrophic factors that may cooperate to support the development and maintenance of the vertebrate nervous system.
Journal of NeuroscienceCellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury
623 Citations1997Ray Grill, Keith K. Murai +3 more
Findings indicate that several spinal pathways contribute to loss of motor function after spinal cord injury, NT-3 is a neurotrophic factor for the injured corticospinal projection, and functional deficits are partially ameliorated by local cellular delivery ofNT-3.
Brain Research ReviewsThe role of neuronal growth factors in neurodegenerative disorders of the human brain
537 Citations1998Bronwen Connor, Mike Dragunow
The role members of the nerve growth factor family (NGF, BDNF and NT-3) and trk receptors as well as additional growth factors (GDNF, TGF-alpha and IGF-I) may play in neurodegenerative disorders of the human brain are examined.
Frontiers in NeurologyCognitive Dysfunction in Multiple Sclerosis
426 Citations2012Joana Guimarães, María José Sá
The cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing, and visual–spatial abilities); the pathophysiological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance.
NeurologyDonepezil improved memory in multiple sclerosis in a randomized clinical trial
300 Citations2004Lauren Krupp, Christopher Christodoulou +4 more
Donepezil improved memory in MS patients with initial cognitive impairment in a single center clinical trial, and a larger multicenter investigation of donepezil in MS is warranted in order to more definitively assess the efficacy of this intervention.
NeurologyDifferences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS
271 Citations2004Stephan C. J. Huijbregts, Nynke F. Kalkers +4 more
Investigating the cognitive skills of patients with relapsing remitting multiple sclerosis, secondary progressive MS, and primary progressive MS relative to healthy control subjects found that patients with different disease courses have different cognitive profiles.
The Corsini Encyclopedia of PsychologyHalstead‐Reitan Neuropsychological Test Battery
264 Citations2010Danny Wedding
Journal of NeuroscienceDisruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits
228 Citations1997Karen Chen, Merry Nishimura +4 more
The findings demonstrate the importance of endogenous NGF for survival and function of basal forebrain cholinergic neurons and reveal that partial depletion of this trophic factor is associated with measurable deficits in learning and memory.
Journal of Neurology Neurosurgery & PsychiatryLongitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings
218 Citations2003M.R. Piras
Mild cognitive impairment in MS patients is revealed particularly consistent with slowing information processing over time, and increased MRI lesions do not correlate with the clinical course of the disease and cognitive deficit evolution.
Journal of Neuroscience ResearchCorrelations between peripheral blood mononuclear cell production of BDNF, TNF‐alpha, IL‐6, IL‐10 and cognitive performances in multiple sclerosis patients
132 Citations2009Agata Katia Patanella, M. Zinno +7 more
A correlation between low BDNF and high IL‐6 production by PBMCs and poorer performances in cognitive tasks in RRMS patients is shown suggesting a possible role of these factors in cognitive impairment in MS.
Progress in brain researchInteractions between the cells of the immune and nervous system: neurotrophins as neuroprotection mediators in CNS injury
125 Citations2004Rinat Tabakman, Shimon Lecht +3 more
Autoimmune neuroprotection is a novel therapeutic approach aimed at shifting the balance between the immune and neuronal cells towards survival pathways in a variety of CNS injuries, and data supporting this concept is focused on.
Psychological MedicineCognitive abnormalities in multiple sclerosis: a psychometric and MRI study
123 Citations1991María A. Ron, Margie Callanan +1 more
The overall performance on psychometric tests was related to the severity of the MRI abnormalities and to the duration of the illness, but was not significantly influenced by the presence of psychiatric morbidity or the degree of physical disability.
NeurologyMulticenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis
112 Citations2011Lauren Krupp, Christopher Christodoulou +12 more
This study provides Class I evidence which does not support the hypothesis that 10 mg of donepezil daily for 24 weeks is superior to placebo in improving cognition as measured by the SRT in people with MS whose baseline RAVLT score was 0.5 SD or more below average.
NeurologyMulticenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis
111 Citations2011Lauren Krupp, Christopher Christodoulou +8 more
This study provides Class I evidence which does not support the hypothesis that 10 mg of donepezil daily for 24 weeks is superior to placebo in improving cognition as measured by the SRT in people with MS whose baseline RAVLT score was 0.5 SD or more below average.
Proceedings of the National Academy of SciencesCognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats
93 Citations2005Giulia D’Intino, Michela Paradisi +5 more
It is demonstrated that a selective deficit in learning and memory performance, as investigated by the Morris water maze test, is a consistent feature in rat encephalomyelitis, which correlates with a decline in choline acetyltransferase activity and nerve growth factor mRNA level in cerebral cortex, hippocampus, and basal forebrain.
Archives of NeurologyInterferon Beta Promotes Nerve Growth Factor Secretion Early in the Course of Multiple Sclerosis
92 Citations2005Katarzyna Biernacki, Jack P. Antel +4 more
Findings suggest that interferon beta-mediated production of NGF at the level of the blood-brain barrier is another potential mechanism contributing to the magnetic resonance imaging-defined effect of interferons beta on brain atrophy when given early in the course of MS.
NatureEffect of nerve growth factor on synaptic depression after axotomy
84 Citations1976Dale Purves, Arild Njå
It is reported here that exogenous NGF can, to a large extent, prevent the synaptic depression seen in adult sympathetic ganglion cells after interruption of their axons.
Acta Neurologica ScandinavicaThe reliability of the MSFC and its components
73 Citations2007Eija Rosti‐Otajärvi, Päivi Hämäläinen +2 more
The MSFC is a multidimensional measurement tool for multiple sclerosis including a measure of ambulation, arm function, and cognition and cognition (Paced Auditory Serial Addition Test [PASAT]).
Acta Neurologica ScandinavicaMemory deficits and early cognitive deterioration in MS
73 Citations2009Päivi Kujala, Raija Portin +1 more
It is suggested that the accuracy of patients’own evaluations of their memory and other cognitive problems is superior to the results of very brief screening batteries, like the MMSE, and brief screening in neuropsychological assessment of MS patients is not recommendable.
Journal of NeurochemistryNeurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons
63 Citations2001Daniel Auld, Françoise Mennicken +2 more
BiomaterialsThe repair of the injured adult rat hippocampus with NT-3-chitosan carriers
55 Citations2009Linhong Mo, Zhaoyang Yang +2 more
Comparison of the lesion control rats and the treated rats indicates that the chitosan carriers loaded either with or without NT-3 may significantly improve the cognitive function after the hippocampus injury.
Clinical and Experimental NeuroimmunologyWhat drives disease in multiple sclerosis: Inflammation or neurodegeneration?
48 Citations2010Hans Lassmann
It is shown that the inflammatory reaction is much more complex, as thought before, and that in the progressive stage of the disease it might become trapped in the central nervous system behind a repaired blood–brain barrier.
PubMedTargeting NGF pathway for developing neuroprotective therapies for multiple sclerosis and other neurological diseases.
42 Citations2011Valeria Colafrancesco, Pablo Villoslada
The nerve growth factor (NGF) was the first neurotrophin discovered for its stimulatory effect on differentiation, survival, and growth of neurons in peripheral and central nervous system, and may represent a new therapeutic approach for the treatment of numerous brain disorders.
American Journal of NeuroradiologyLow Choline Concentrations in Normal-Appearing White Matter of Patients with Multiple Sclerosis and Normal MR Imaging Brain Scans
35 Citations2007Mika Gustafsson, Olof Leinhard Dahlqvist +3 more
It is suggested that patients with MS who lack lesions in the brain constitute a separate entity and may have increased protective or healing abilities.
PathophysiologyThe rs2030324 SNP of brain-derived neurotrophic factor (BDNF) is associated with visual cognitive processing in multiple sclerosis
27 Citations2010Bianca Weinstock‐Guttman, Ralph H. B. Benedict +6 more
The C allele of BDNF rs2030324 is associated with protection against visual cognitive processing deficits via mechanisms that appear associated with the volume of the thalamus.
Medical Entomology and ZoologyThe Complete Book of Intelligence Tests
25 Citations2005Philip J. Carter
Journal of NeurologyIs there a role for neurotrophins in the pathology of multiple sclerosis?
20 Citations2007Ralf A. Linker, De-Hyung Lee +2 more
Analysis of recently developed conditional knockout mice with a selective suppression of BDNF production in different subsets of immune cells may improve the understanding of the role of this neurotrophin during autoimmunity of the CNS.
Journal of NeurochemistryNeurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons
17 Citations2001Daniel Auld, Françoise Mennicken +2 more
Long‐term exposure of basal forebrain cholinergic neurons to nerve growth factor, and in a less‐potent fashion the other neurotrophins, enhanced the release of acetylcholine, which was dependent upon a vesicular pool and the availability of extracellular choline.
Journal of NeuroimmunologyImmune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients
15 Citations2011Alicja Kalinowska, Mikołaj A. Pawlak +3 more
It is found that neurotrophin-3 PBMCs concentration is strongly correlated with brain-parenchymal fraction and corpus callosum cross-sectional area, which are well-established brain atrophy measures, and might exert a direct or indirect neuroprotective effect in MS.
Future NeurologyNeurotrophin gene therapy for Alzheimer‘s disease
6 Citations2006Armin Blesch
Progress in the targeted delivery of neurotrophic factors by gene therapy allows investigators to determine for the first time, in clinical trials, whether growth factors can influence neuronal function in the diseased human nervous system.
