APPRAISAL OF INTRADERMAL IMMUNISATION AGAINST HEPATITIS B
The LancetPublished 1 February 1987
A. J. Zuckerman
Citations43
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
La vaccination par doses faibles en injections intradermiques peut donner d'excellents resultats mais l'application sur une grande echelle pose encore des problemes.
Abstract
La vaccination par doses faibles en injections intradermiques peut donner d'excellents resultats mais l'application sur une grande echelle pose encore des problemes (efficacite moindre apres rappel, necessite d'un personnel experimente, danger d'une injection sous-cutanee inefficace)
Keywords
Immunology and MicrobiologyMedicine
Expanded Programme on Immunization
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50 Citations1984G. Zoulek, B. Lorbeer +2 more
Intradermal inoculation of hepatitis B vaccine (HBsAg subtype adw) caused no side effects, but the vaccine was less immunogenic than following intramuscular administration, and does not offer a major advantage to the generally used intamuscular immunization.
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Two low-dose intradermal regimens for hepatitis B vaccination were compared with the standard 1 ml dose administered intramuscularly to healthy, 22-42 year old individuals to suggest that a shortened regimen of intrader mal vaccine may be effective in healthy adults.
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Three 1 microgram or 2 micrograms doses of Merck, Sharp and Dohme plasma vaccine were given to 119 infants of mothers negative for antibody to hepatitis B surface antigen, suggesting that maternal antibody does not interfere with the infant's immune response to low doses of vaccine.
