The polypeptides of adenovirus
VirologyPublished 1 February 1974
Gernot Walter, Jacob V. Maizel
Citations58
SJR quartileQ2
SJR score0.74
SNIP0.60
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TL;DR
Three “early” polypeptides induced by adenovirus type 2 infection of HeLa cells have been detected and two, E1 and E2, are found in cytoplasmic extracts and E3 is present in nuclear extracts.
Abstract
Three “early” polypeptides induced by adenovirus type 2 infection of HeLa cells have been detected. Two, E1 and E2, are found in cytoplasmic extracts. E3 is present in nuclear extracts. Increased resolution in acrylamide gel electrophoresis and prefractionation permitted these observations along with the detection of “late” polypeptides similar in amount but having higher apparent MW than the core polypeptides of the adenovirion. At late times the great bulk of protein is in structural polypeptides. Late nonstructural proteins cannot be positively identified and, if present, are synthesized at levels of 0.1–1% of the structural proteins.
Keywords
Biochemistry, Genetics and Molecular BiologyEnvironmental Science
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