Cost-effectiveness Analysis of a Rotavirus Immunization Program for the United States
JAMAPublished 6 May 1998
Alexander W. Tucker
Citations357
SJR quartileQ1
SJR score5.35
SNIP10.71
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TL;DR
A US rotavirus immunization program would be cost-effective from the perspectives of society and the health care system, although the cost of the immunizationprogram would not be fully offset by the reduction in health care cost of rotav virus diarrhea unless the price fell to $9 per dose.
Abstract
A US rotavirus immunization program would be cost-effective from the perspectives of society and the health care system, although the cost of the immunization program would not be fully offset by the reduction in health care cost of rotavirus diarrhea unless the price fell to $9 per dose.
Keywords
Medicine
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A rotavirus vaccine program will require improved surveillance, including the timely collection of data from sentinel hospitals, in which a diagnosis of rotav virus can be established or ruled out for all children hospitalized for diarrhea.
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317 Citations1997Jaana Joensuu, Eeva Koskenniemi +2 more
RRV-TV vaccine was highly effective against severe rotavirus gastroenteritis in young children, and incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotvirus gastroEnteritis by 90% and severe gastroenterritis of all causes in youngChildren by 60%.
PubMedSafety and efficacy of high-dose rhesus-human reassortant rotavirus vaccines--report of the National Multicenter Trial. United States Rotavirus Vaccine Efficacy Group.
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RRV-TV is highly protective against very severe, dehydrating rotavirus gastroenteritis; vaccination was most protective against serious rotav virus illness.
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243 Citations1998Umesh D. Parashar, Robert C. Holman +3 more
Examination of the National Hospital Discharge Survey for trends in rotavirus-associated hospitalizations among US children aged 1 month through 4 years indicates the need for vaccines and indicates that NHDS data could be used to monitor the impact of a US rotav virus immunization program.
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226 Citations1981Marc Gurwith, Wanda M. Wenman +3 more
Rotavirus infection was uncommon in the first six months of life, but by two years of age, 62% of the infants had had at least one infection, and neither breast feeding nor the presence of antibody to rotavirus in cord blood appeared to be protective.
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Reassortants containing either HRV surface protein and as few as four bovine rotavirus genes were safe in infants, and a monovalent WC3 reassortant of serotype G1 specificity was 64%-100% protective in placebo-controlled trials.
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163 Citations1990David O. Matson, M K Estes
The availability since 1983 of diagnostic assays less expensive than electron microscopy was associated with increased rotavirus detection and only 67% of rotav virus-positive samples came from children likely to have had community-acquired acute gastroenteritis.
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Data indicate that RRV-TV is moderately efficacious in preventing all episodes of gastroenteritis caused by rotavirus and is most efficacious against the severe disease characteristic of rotaviral illness.
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96 Citations1993Pablo Avendano, David O. Matson +4 more
Outdoor care for pediatric diarrhea is a major health care cost in the United States, and twenty-one percent of this cost was attributable to rotavirus diarrhea.
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91 Citations1995Jean C. Smith, Anne C. Haddix +2 more
Economic and disease reduction benefits would be realized from the use of an RV vaccine that is partially protective against severe RV diarrhea and cost effectiveness increased with greater vaccine efficacy or decreased vaccine cost.
The Journal of Infectious DiseasesDiarrhea among Infants and Young Children in Canada: A Longitudinal Study in Three Northern Communities
87 Citations1983Marc Gurwith, Wanda M. Wenman +4 more
No protective effect of breast-feeding was discerned, since infection due to rotavirus occurred more frequently and earliest in neonatal life in Eskimo Point, the community with the highest rate of Breast-feeding.
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79 Citations1984James S. Koopman, VERNA J. TURKISH +4 more
The total direct costs of diarrheal illness to society were estimated to be due more to hospitalization than to outpatient care, and the rotavirus-infected patients did not, however, have more frequent respiratory symptoms.
The Pediatric Infectious Disease JournalAcute diarrhea in Baltimore children attending an outpatient clinic
71 Citations1988Karen L. Kotloff, Steven S. Wasserman +6 more
Only rotavirus, enteric adenovirus and Salmonella were significantly associated with diarrhea, and cases were more likely to have measures of socioeconomic deprivation, such as household crowding, low maternal educational level and low birth weight, when compared to controls.
American Journal of EpidemiologyNonparticipation as a Determinant of Adverse Health Outcomes in a Field Trial of Oral Cholera Vaccines
36 Citations1992J. D. Clemens, F F van Loon +9 more
Nonparticipation was associated with clinically cogent adverse health outcomes, but that the magnitude of these associations varied according to the reason for nonparticipation, underscore the caution required in assessing vaccine efficacy with controls who are not vaccinated because of choices made by patients or vaccinators.
Controlled Clinical TrialsA potpourri of RCT topics
18 Citations1982Thomas C. Chalmers
Examples of randomization of the first patient, factorially structured treatments, and time lags between innovation, RCTs, and practice are known.