Diurnal locomotor activity in rats: Effects of hippocampal ablation and adrenalectomy
Behavioral BiologyPublished 1 February 1977
P. Michael Iuvone, Carol Van Hartesveldt
Citations20
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A diurnal fluctuation in the open-field activity of rats is described and adrenalectomy did not abolish the diurnal pattern of locomotor activity, but it reduced both the morning and evening activities of rats with hippocampal lesions.
Abstract
In the present study, we have described a diurnal fluctuation in the open-field activity of rats. Hippocampal lesions greatly magnify this diurnal fluctuation, primarily by increasing the activity observed in the morning prior to the onset of light. To test whether this diurnal fluctuation is related to the cyclic release of adrenal hormones, the subjects were adrenalectomized. Adrenalectomy did not abolish the diurnal pattern of locomotor activity, but it reduced both the morning and evening activities of rats with hippocampal lesions.
Keywords
Neuroscience
Clinical ChemistryPractical Procedure for Estimation of Corticosterone or Hydrocortisone
550 Citations1958Robert Silber, R.D. Busch +1 more
A simplified fluorometric procedure for corticosterone or hydrocortisone has been described and has practical applications for the estimation of these steroids in samples that are small in volume or low in concentration, or in studies that are designed primarily to demonstrate increases or decreases in adrenocortical hormones in plasma or adrenals without requiring absolute specificity.
JAMAAdvances in Neuroendocrinology.
480 Citations1963Alvin Brodish
This volume contains a series of well-organized papers presented at a symposium on neuroendocrinology held in December, 1961, and represents an attempt to collect, review, and evaluate the accumulated knowledge in this steadily growing field.
Physiology & BehaviorBehavior of hippocampal lesioned rats in home cage and novel situations
158 Citations1968Leonard E. Jarrard
H hippocampal animals slept less than controls under both ad libitum and food deprivation conditions and were more active early in the session but later spent more time than controls with the food, interpreted as evidence for a motivational involvement of the hippocampus.
Brain ResearchRetention of corticosterone by cell nuclei from brain regions of adrenalectomized rats
142 Citations1970Bruce S. McEwen, Jay M. Weiss +1 more
The retention mechanism in hippocampal nuclei is highly specific for corticosterone and shows an interesting time dependence.
Animal Behaviour‘Emotionality’ and adrenal cortical function: Effects of strain, tests, and the 24-hour corticosterone rhythm
79 Citations1967Robert Ader, Stanford B. Friedman +1 more
Open-field testing of rats and mice did not yield significant behaviour-steroid correlations in experiment 1, but albino and hooded rats maintained under a 12 hr light-dark regimen were observed in a reaction-to-handling situation and an open-field at the peaks and troughs in the previously determined 24 hr rhythm in adrenal cortical activity.
Experimental NeurologyHippocampal control of behavioral arousal: Duration of lesion effects and possible interactions with recovery after frontal cortical damage
75 Citations1971Byron A. Campbell, Percy Ballantine +1 more
It appears that the hippocampus shares arousal control functions with frontal cortex, that it is partially responsible for the recovery that has been reported to occur after frontal lesions, but does not itself recover after damage.
Behavioral BiologyActivity changes related to the location of lesions in the hippocampus
65 Citations1975Linda Lanier, Robert L. Isaacson
The results of within-group correlational analyses indicate that differential CA field destruction was not correlated with open field activity.
Hormones and BehaviorDissociation of open-field behavior and pituitary-adrenal function
55 Citations1973Judith M. Stern, Mary S. Erskine +1 more
It is concluded that pituitary-adrenal secretions do not mediate differences in OF behavior and that since the complex of low overall activity, high defecation and high adrenocortical levels are frequently dissociated, these responses cannot serve to validate each other as measures of emotionality.
Physiology & BehaviorDiurnal cycle and ACTH facilitation of shuttlebox avoidance
47 Citations1972Robert R. Pagano, Richard W. Lovely
The results mimic the effects of septal or hippocampal lesions in shuttlebox and are viewed as consistent with the hypothesis that the lesion results are due to a hormonally mediated mechanism.
Behavioral BiologyLocomotor activity and plasma corticosterone in rats with hippocampal lesions
39 Citations1976P. Michael Iuvone, Carol Van Hartesveldt
The effects of hippccampal and neocortical lesions on open field locomotor activity and the levels of plasma corticosterone immediately after the activity testing session were examined to discuss reduced fear and the perception of aversive stimuli by rats with hippocampal lesions.
Physiology & BehaviorHippocampal lesions and shuttlebox avoidance behavior: A fear hypothesis
38 Citations1972Seymour M. Antelman, Thomas S. Brown
Rats with hippocampal damage were compared to cortically lesioned and normal controls in the acquisition of a shuttlebox avoidance task and animals with lesions of the hippocampus were more fearful than control animals.
NeuroendocrinologyEffects of Differential Hippocampal Damage upon Rhythmic and Stress-Induced Corticosterone Secretion in the Rat
28 Citations2008Linda Lanier, Carol Van Hartesveldt +2 more
The effects of dorsal, ventral, and near-total hippocampal lesions upon both rhythmic and stress-induced corticosterone secretion in adult male rats were examined and there were no significant differences across experimental groups.
Experimental NeurologySingle and two-stage hippocampal lesions: A similar syndrome
22 Citations1973Ronald G. Dawson, Lily Conrad +1 more
There were no differences between one-stage and two-stage bilateral removal of the hippocampus on tests given at equal recovery times after the completion of surgery, and recovery (or sparing) of function occurs to an equal degree after both types of lesions.
Hormones and BehaviorEffects of adrenalectomy on open-field behavior in rats
19 Citations1972Justin M. Joffe
It was found that Adx females defecated significantly more than unoperated controls and the defecation scores and activity pattern displayed by Adx animals is characteristic of more “emotional” rats.
Physiology & BehaviorThe ventromedial hypothalamus and aggressive behaviors
16 Citations1972Sebastian P. Grossman
Drug injections into the ventromedial hypothalamus of female rats which had been shown to facilitate avoidance behavior and disinhibit punished operant responding did not modify aggressive behaviors in several situations.