Androgens Prevent Normally Occurring Cell Death in a Sexually Dimorphic Spinal Nucleus
SciencePublished 16 August 1985
Ernest J. Nordeen, Kathy W. Nordeen, Dale R. Sengelaub, Arthur P. Arnold
Citations467
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
The results suggest that steroid hormones determine sex differences in neuron number by regulating normally occurring cell death and that the timing of this cell death may therefore define critical periods for steroid effects on neuron number.
Abstract
The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference during a critical perinatal period, which coincides with normally occurring cell death in the SNB region. Sex differences in SNB motoneuron number arise primarily because motoneuron loss is greater in females than in males during the early postnatal period. Perinatal androgen treatment in females attenuates cell death in the SNB region, reducing motoneuron loss to levels typical of males. The results suggest that steroid hormones determine sex differences in neuron number by regulating normally occurring cell death and that the timing of this cell death may therefore define critical periods for steroid effects on neuron number.
Keywords
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