Primary Nocturnal Enuresis: A Urodynamic Study Spanning Three Generations
Scandinavian Journal of Urology and NephrologyPublished 1 September 1995
Brian Birch, Ronald Miller
Citations13
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
For the first time, a family of adults with urodynamically proven instability spanning three generations is described, lending support to the proposition that such detrusor instability is transmitted as an autosomal dominant characteristic.
Abstract
The familial incidence of primary nocturnal enuresis is well recognised. Twin studies suggest there to be a significant genetic component to the aetiology of this disorder. However, family studies to date have been based on symptomatic enquiry alone although detrusor instability is a recognised feature of primary noctural enuresis in 70-80% of cases. For the first time we describe a family of adults with urodynamically proven instability spanning three generations. The pattern of inheritance lends support to the proposition that such detrusor instability is transmitted as an autosomal dominant characteristic.
Keywords
Medicine
American Journal of Physiology-Renal PhysiologyAbnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis
479 Citations1989Søren Rittig, Ulla Breth Knudsen +3 more
An abnormal diurnal rhythm of AVP seems to be an important pathophysiological factor in enuresis, explaining the abnormally high nocturnal urinary volume and the low noctual urinary osmolality found in these patients.
Archives of Disease in ChildhoodEnuresis and spontaneous cure rate: Study of 1129 enuretics
444 Citations1974W. I. Forsythe, Amy M. Redmond
A long-term follow-up of 1129 children with nocturnal enuresis, not treated by the electric alarm, has shown that the annual spontaneous cure rate between 5 and 9 years of age was 14%, between 10 and 14 years 16%, and between 15 and 19 years 16%.
The Journal of UrologyDiurnal Anti-Diuretic-Hormone Levels in Enuretics
261 Citations1985Jens Peter Nørgaard, E. B. Pedersen +1 more
The study suggests that the normal increase in nighttime antidiuretic hormone levels is absent in enuretics, who show a stable hormone level both day and night, and the volume of night urine production approximates day urine production per hour.
Developmental Medicine & Child NeurologyDEVELOPMENTAL HISTORY AND NEUROLOGICAL FINDINGS IN ENURETIC CHILDREN
117 Citations1989Marjo‐Riitta Järvelin
It is suggested that there are at least two different groups of enuretic children: those with daytime or day‐ and night‐time enuresis, whose condition is associated with neurological damage; and those with an obvious delay in maturation of central nervous bladder control, who have night‐ Time Enuresis only.
Archives of Pediatrics and Adolescent MedicineEnuresis in Twins
105 Citations1971Harry Bakwin
Comparison of the incidence of enuresis in monozygotic and same-sex dizygotic twins revealed that bed-wetting after the fourth birthday was present in 146 out of 676 twin children, an incidence of 22%.
Acta PaediatricaAetiological and Precipitating Factors for Childhood Enuresis
88 Citations1991Marjo‐Riitta Järvelin, I. Moilanen +5 more
These models showed that there are similarities between nocturnal and diurnal enuresis, although there are still many differences and every individual case requires consideration of all these disposing factors.
American Journal of Medical GeneticsUrofacial (Ochoa) syndrome
75 Citations1987Bernardo Ochoa, Robert J. Gorlin +2 more
The term urofacial syndrome is suggested for this disorder, occurrence of the disorder in multiple sibs, normal parents, increased parental consanguinity, and equal sex ratio indicate autosomal recessive inheritance.
British Journal of UrologyThe Urodynamic Assessment of Adult Enuresis
59 Citations1975Michael Torrens, C Collins
There is a strong case for relating diagnosis, prognosis and treatment to urodynamic assessment for adult enuresis, because of the lack of association between symptoms, signs and objective measurements.
The Journal of UrologyThe Role of Family History in Predicting Response to Desmopressin in Nocturnal Enuresis
57 Citations1993Ronald J. Hogg, Doug Husmann
It is concluded that a high rate of success may be predicted when desmopressin is used in patients with familial nocturnal enuresis, whereas less optimism is warranted when no family history ofNocturnal Enuresis can be elicited.
American Journal of Diseases of ChildrenENURESIS
35 Citations1935LOUISE G. FRARY
The purpose of this paper is to present data supporting this thesis, collected for 59 clans, including 221 fraternities, in which, of a total of 787 individual members, 239 are known to have been enuretic.
Pediatric Clinics of North AmericaIncontinence and Enuresis
32 Citations1987Gordon A. MeLorie, Douglas A. Husmann
By using the criteria outlined in this article, one can manage selective urologic evaluation of the diurnally incontinent and enuretic child, saving most patients the cost and stress of more in-depth diagnostic evaluations.
Developmental Medicine & Child NeurologyNocturnal Enuresis and Minor Neurological Dysfunction at 12 Years: A Follow‐Up Study
31 Citations1991Roelineke J. Lunsing, Mijna Hadders‐Algra +2 more
It is concluded that children with MND are more vulnerable to primary nocturnal enuresis, particularly in the presence of lower social class and a positive family history.
British Journal of UrologyNeurophysiological Measurements in Primary Adult Enuretics
18 Citations1985A. Fidas, Niall T.M. Galloway +2 more
The nerve supply of the lower urinary tract was studied in 25 primary adult enuretics by full urodynamic assessment and neurophysiological measurements to find defects in sensory and motor innervation correlated with the clinical dysfunction.
British Journal of UrologyHistological and Urodynamic Study of the Bladder in Enuretic Children
16 Citations1983C. M. BOOTH, J. A. Gosling
In a study of the bladders of 12 enuretic children by cystoscopy, light microscopy and urodynamics, cystoscopic trabeculation was found in 10 cases, and Histologically, the trABeculation resembled adult trabECulation of obstructive aetiology, collagen infiltration being the characteristic hallmark.
Developmental Medicine & Child NeurologyEnuresis and Hyperventilation Response in the EEG
16 Citations1981B Kaada, Arthur Retvedt
It was found that an increased hyperventilation response occurred mainly among children with primary enuresis (bed‐wetters from birth), and this was true even if the children had a ‘uropathy’.
British Journal of UrologyAdult Enuresis‐a Symptomatic and Urodynamic Assessment
15 Citations1980Jon Hindmarsh, P.O. Byrne
There was a significant correlation between the presence of diurnal symptoms and bladder instability and between nocturia and instability in patients with primary enuresis.