Implementation of a rapid influenza A/B and RSV direct molecular assay improves emergency department oseltamivir use in paediatric patients
Journal of Medical MicrobiologyPublished 10 January 2018
Stephanie L. Mitchell, Yeh-Chung Chang, Kristen A. Feemster, Ana María Cárdenas
Citations9
SJR quartileQ2
SJR score0.62
SNIP0.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Use of Direct Flu/RSV provides results rapidly, which leads to more appropriate use of oseltamivir, and the ease of use of this assay and quick TAT allows for prompt decision‐making, which is essential for patient care and effective disease control during the influenza season.
Abstract
Use of Direct Flu/RSV provides results rapidly, which leads to more appropriate use of oseltamivir. The ease of use of this assay and quick TAT allows for prompt decision-making, which is essential for patient care and effective disease control during the influenza season.
Keywords
Medicine
New England Journal of MedicineThe Burden of Respiratory Syncytial Virus Infection in Young Children
2,245 Citations2009Caroline Breese Hall, Geoffrey A. Weinberg +11 more
RSV infection is associated with substantial morbidity in U.S. children in both inpatient and outpatient settings, suggesting that control strategies targeting only high-risk children will have a limited effect on the total disease burden of RSV infection.
New England Journal of MedicineRespiratory Syncytial Virus Infection in Elderly and High-Risk Adults
2,212 Citations2005Ann R. Falsey, Patricia Hennessey +3 more
RSV infection is an important illness in elderly and high-risk adults, with a disease burden similar to that of nonpandemic influenza A in a population in which the prevalence of vaccination for influenza is high.
Journal of Clinical MicrobiologyComparison of the Idaho Technology FilmArray System to Real-Time PCR for Detection of Respiratory Pathogens in Children
140 Citations2011Virginia Pierce, Michael Elkan +3 more
The FilmArray Respiratory Panel (RP) multiplexed nucleic acid amplification test was compared to laboratory-developed real-time PCR assays for the detection of various respiratory viruses and certain bacterial pathogens and detection of coinfections and correct identification of influenza A virus subtypes were comparable to those of real- time PCR.
International Journal of Infectious DiseasesContribution of the FilmArray Respiratory Panel in the management of adult and pediatric patients attending the emergency room during 2015–2016 influenza epidemics: An interventional study
34 Citations2019Laurent Busson, Magali Bartiaux +14 more
Results from the FilmArray Respiratory Panel do not appear to impact admission or antibiotic prescription, with the exception of a lower admission rate for children who tested positive for influenza B.
Journal of Clinical MicrobiologyEvaluation of Simplexa Flu A/B & RSV for Direct Detection of Influenza Viruses (A and B) and Respiratory Syncytial Virus in Patient Clinical Samples
29 Citations2013Musa Hindiyeh, Liat Kolet +4 more
The Simplexa Flu A/B & RSV kit was evaluated using a modified protocol, supplied by the manufacturer, that eliminates the RNA extraction step, and the assay's sensitivity, specificity, and positive and negative predictive values were 95.1, 99.6, and 98.6%, respectively.
PubMedEmergency department chief complaint and diagnosis data to detect influenza-like illness with an electronic medical record.
27 Citations2010Larissa May, Beth Ann Griffin +6 more
Comparing time series and applying syndromic detection algorithms, which complaints and diagnoses are the best indicators for the start of the influenza season when compared to Centers for Disease Control regional data for Influenza-Like Illness for the 2005 to 2006 influenza season are determined.
Diagnostic Microbiology and Infectious DiseaseComparison of the Simplexa™ Flu A/B & RSV kit (nucleic acid extraction–dependent assay) and the Prodessa ProFlu+™ assay for detecting influenza and respiratory syncytial viruses
17 Citations2013Suresh B. Selvaraju, Adrienne Bambach +4 more
The relative performance of 2 widely used reverse transcription polymerase chain reaction (RT-PCR) assays, the Focus diagnostics Simplexa™ Flu A/B & RSV kit (nucleic acid extraction-dependent assay) and the Prodessa Proflu+™ assay, was evaluated using 735 prospectively and retrospectively collected nasopharyngeal swab specimens.
eScholarship (California Digital Library)Emergency Department Chief Complaint and Diagnosis Data to Detect Influenza-Like Illness with an Electronic Medical Record
17 Citations2010Larissa May, Beth Ann Griffin +6 more
Infection Control and Hospital EpidemiologySurveillance for Healthcare-Associated Influenza-Like Illness in Pediatric Clinics: Validity of Diagnosis Codes for Case Identification
6 Citations2016Kristen A. Feemster, Folasade Odeniyi +4 more
A definition based on the International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis code for healthcare-associated influenza-like illness among young children in a large pediatric network demonstrated high positive and negative predictive values.
