Findings in female offspring of women exposed in utero to diethylstilbestrol
Obstetrics and GynecologyPublished 1 February 2002
Raymond H. Kaufman
Citations72
SJR quartileQ1
SJR score1.97
SNIP2.22
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TL;DR
The absence of abnormalities in the lower genital tract in third‐generation women compared with the high frequency of these abnormalities in their mothers suggests that third‐ generation carryover effects of in utero DES exposure are unlikely.
Abstract
The absence of abnormalities in the lower genital tract in third-generation women compared with the high frequency of these abnormalities in their mothers suggests that third-generation carryover effects of in utero DES exposure are unlikely.
Keywords
Social SciencesEnvironmental Science
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202 Citations1998Robert F. Newbold
Data suggest that the reduced fertility observed in the DES F1 female mice was not transmitted to their descendants; however, increased susceptibility to tumor formation is apparently transmitted to subsequent generations.
JAMACancer Risk in Women Exposed to Diethylstilbestrol In Utero
197 Citations1998Elizabeth E. Hatch
Because exposed daughters included in this study were, on average, only 38 years old at last follow-up, continued surveillance is warranted to determine whether any increases in cancer risk occur during the menopausal years.
Obstetrical & Gynecological SurveyVaginal Epithelial Changes in Young Women Enrolled in the National Cooperative Diethylstilbestrol Adenosis (Desad) Project
111 Citations1979Peter C. O’Brien, Kenneth L. Noller +5 more
Analysis of data on the 298 women who were identified by record review and whose prenatal records contained complete information about drug exposure indicated that VEC is most closely associated with the timing of the onset of inlrauterine exposure to diethylstilbestrol (DES), total dose, and length of exposure.
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82 Citations1978Darwin R. Labarthe, Ervin Adam +12 more
The National Cooperative Diethylstilbestrol Adenosis (DESAD) Project has completed the major portion of its enrollment phase with the examination of more than 3000 daughters of women taking synthetic nonsteroidal estrogens during pregnancies occurring from the early 1940s to the mid-1960s.
JNCI Journal of the National Cancer InstituteTumors of Female Offspring of Mice Exposed Prenatally to Diethylstilbestrol<xref ref-type="fn" rid="FN2">2</xref>
78 Citations1984Bruce E. Walker
The DES-lineage mice did not show the increased frequency of adenomyosis and squamous metaplasia of the uterus, nor the reduced frequency of corpora lutea seen in mice exposed prenatally to DES, and the types of tumors that commonly occur spontaneously in the CD-1 strain appeared with comparable frequency in the 2 groups of mice.
American Journal of Obstetrics and GynecologyStructural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project
77 Citations1984John A. Jefferies, Stanley J. Robboy +8 more
Structural anomalies of the cervix or vagina were found in 25% of the 1,655 subjects identified by review of prenatal records, and multivariate analysis indicated close association of the anomalies with the gestational week of first exposure and the total dose.
International Journal of CancerMulti‐generational carcinogenesis from diethylstilbestrol investigated by blastocyst transfers in mice
33 Citations1995Bruce E. Walker, Lori A. Kurth
DES has a multi‐generational effect transmitted through the blastocyst, which is consistent with fetal germ cell mutation from DES, and the pre‐natal exposure of the host to DES produced a maternal environment which increased the incidence of ovarian and uterine tumors.
Cells Tissues OrgansFailure to Detect a Second-Generation Effect in Female Mice after Neonatal Treatment with an Estrogen (Diethylstilbestrol)
10 Citations1992J.-G. Forsberg, Anders Hailing
The results indicate that treatment of neonatal female mice with DES does not affect the female germ cells as far as concerns factors associated with the development of HCE or reduced fertility in the next generation.