CELL-MEDIATED (DELAYED) HYPERSENSITIVITY IN PATIENTS WITH SUMMER HAY-FEVER
The LancetPublished 1 December 1969
Jonathan Brostoff, I.M. Roitt
Citations104
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
Pollen-induced lymphocyte transformation in hay-fever subjects with clinical immediate hypersensitivity reflects the presence of a sensitised thymus-dependent cell population, which also gives rise to positive macrophage and leucocyte migration-inhibition tests in vitro and delayed-type skin tests in vivo.
Abstract
Pollen-induced lymphocyte transformation in hay-fever subjects with clinical immediate hypersensitivity reflects the presence of a sensitised thymus-dependent cell population, which also gives rise to positive macrophage and leucocyte migration-inhibition tests in vitro and delayed-type skin tests in vivo. It is postulated that the thymus-dependent (T-) lymphocytes cooperate in the production of IgE antibody by B-lymphocytes of the plasma-cell series. Lymphocyte transformation per se should still be regarded as a manifestation of cell-mediated (delayed) hypersensitivity in vitro, whatever the apparent clinical correlations may be.
Keywords
Immunology and MicrobiologyMedicineBiochemistry, Genetics and Molecular Biology
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