Role of strontium-89 as adjuvant to palliative external beam radiotherapy is questionable: Results of a double-blind randomized study
International Journal of Radiation Oncology*Biology*PhysicsPublished 16 July 2003
Sigbjørn Smeland, Björn Erikstein, Magne Aas, Eva Skovlund, Siri Lothe Hess, Sophie D. Fosså
Citations78
SJR quartileQ1
SJR score2.06
SNIP1.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Sr, adjuvant to ERBT, does not seem to reduce the number of patients with subjective progression at 3 months, and patients should be referred for palliative RT before their bone pain requires high doses of opiates.
Abstract
(89)Sr, adjuvant to ERBT, does not seem to reduce the number of patients with subjective progression at 3 months. Patients should be referred for palliative RT before their bone pain requires high doses of opiates. In radiotherapy trials, the evaluation of pain and pain relief remains problematic because of the confounding use of analgesics.
Keywords
Medicine
JNCI Journal of the National Cancer InstituteThe European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
15,964 Citations1993N.K. Aaronson, Sam H. Ahmedzai +17 more
The reliability and validity of the EORTC QLQ-C30 questionnaire were highly consistent across the three language-cultural groups studied: patients from English-speaking countries, Northern Europe, and Southern Europe.
Journal of Clinical OncologyInterpreting the significance of changes in health-related quality-of-life scores.
2,944 Citations1998David Osoba, George Rodrigues +3 more
The significance of changes in QLQ-C30 scores can be interpreted in terms of small, moderate, or large changes in quality of life as reported by patients in the SSQ.
New England Journal of MedicinePain and Its Treatment in Outpatients with Metastatic Cancer
2,011 Citations1994Charles S. Cleeland, René Gonin +5 more
The adequacy of prescribed analgesic drugs using guidelines developed by the World Health Organization was assessed, the factors that influenced whether analgesia was adequate were studied, and the effects of inadequate analgesia on the patients' perception of pain relief and functional status were determined.
British Journal of CancerWho should measure quality of life, the doctor or the patient?
913 Citations1988ML Slevin, Hilary Plant +3 more
It is concluded that if a reliable and consistent method of measuring quality of life in cancer patients is required, it must come from the patients themselves and not from their doctors and nurses.
DefinitionsEuropean Organization for Research and Treatment of Cancer
760 Citations2020National Cancer Institute
It is indicated that bone marrow examination should be considered as an essential part of staging procedures in patients with a FCL first presenting in the skin and that, from a clinical point of view, bone marrow examination appears to have limited value in patients with a CBCL.
International Journal of Radiation Oncology*Biology*PhysicsResults of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer
530 Citations1993Arthur T. Porter, Alexander McEwan +13 more
It is concluded that the addition of strontium-89 is an effective adjuvant therapy to local field radiotherapy reducing progression of disease as evidenced by new sites of pain and the requirement of further radiotherapy and improving quality-of-life and need for analgesic support in this group of patients.
CancerThe memorial pain assessment card. A valid instrument for the evaluation of cancer pain
331 Citations1987Baruch Fishman, Sara Pasternak +4 more
The Memorial Pain Assessment Card can distinguish pain intensity from pain relief and from general psychological distress, and it can provide multidimensional assessment that is practically equivalent to the full assessment battery.
Radiotherapy and OncologyInternational consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases
310 Citations2002Edward Chow, Jackson Wu +4 more
An acceptable set of endpoints has been agreed upon for future clinical trials to promote consistency in reporting and it is intended that the consensus will be re-examined every 5 years.
PubMedStrontium-89 therapy for the pain of osseous metastases.
127 Citations1985Edward B. Silberstein, Craig C. Williams
Strontium-89 may be useful as adjuvant therapy for diffuse bone pain, but a double-blind study comparing it to other nonnarcotic modalities is required.
BoneMetastatic bone disease: Clinical and therapeutic aspects
116 Citations1992J.J. Body
The classical radionuclide bone scan remains the most effective tool for the screening of metastatic bone disease, but X-rays are more specific and remain the essential tool forThe diagnosis and characterization of bone metastases.
British Journal of CancerLess pain does equal better quality of life following strontium-89 therapy for metastatic prostate cancer
82 Citations2001Sandra Turner, S Gruenewald +2 more
This study supports the presumption that improvement in pain following Sr-89 is accompanied by better QoL, and indicates that in the palliative setting, PSA may not provide a useful surrogate for treatment outcome.
Nuclear Medicine CommunicationsUsefulness of strontium-89 for bone pain palliation in metastatic breast cancer patients
62 Citations2000David Fuster, R. HERRANZ +6 more
In conclusion, breast cancer patients with metastatic bone pain can benefit from therapy with 89Sr and the treatment may be repeated safely and with the same efficacy as is achieved after the first dose.
OncologyStrontium-89 Chloride in the Treatment of Bone Metastases from Breast Cancer
57 Citations1998Nikolaos Baziotis, E. Yakoumakis +4 more
British Journal of Cancer89Strontium in bone metastases from hormone resistant prostate cancer: palliation effect and biochemical changes
38 Citations1992Sophie D. Fosså, Elisabeth Paus +3 more
It is concluded that 89Sr represents a worthwhile therapeutic modality in the palliation treatment of patients with hormone resistant prostate cancer, though the biological significance of frequently increasing PSA and decreasing APHOS is not yet completely understood.
British Journal of UrologyQuality of life after palliative radiotherapy in patients with hormone‐resistant prostate cancer: single institution experience
35 Citations1994S.D. Fosså
In patients with hormone-resistant prostate cancer, quality of life assessment is both possible and desirable for the evaluation of palliative treatment, and palliatives radiotherapy proved less effective than reports in the literature might suggest.
Australasian RadiologyStrontium‐89 treatment for prostate cancer bone metastases: Does a prostate‐specific antigen response predict for improved survival?
32 Citations2001Adam Zyskowski, David S. Lamb +3 more
A PSA response following strontium-89 treatment appears to predict for improved survival in patients with bone metastases from carcinoma of the prostate.
PubMedPalliative radiotherapy in prostate cancer.
24 Citations1997C N Catton, M. Gospodarowicz
Palliative radiotherapy provides a simple and effective method of treating many of the other complications of progressive prostate cancer and these are discussed.