Nucleophilic Heterocyclic Carbene Catalyzed Annulation of Enals to Chalcones in Methanol: A Stereoselective Synthesis of Highly Functionalized Cyclopentanes
Organic LettersPublished 18 May 2009
Vijay Nair, Beneesh P. Babu, Sreekumar Vellalath, Vimal Varghese, Anabha E. Raveendran, Eringathodi Suresh
Citations81
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SJR score1.24
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Abstract
Homoenolates generated from enals by nucleophilic heterocyclic carbene (NHC) catalysis undergo annulation with chalcones in methanol to afford methyl beta-hydroxycyclopentanecarboxylates, stereoselectively. Construction of four contiguous stereocenters in a stereoselective manner is noteworthy.
Keywords
Chemistry
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