Microvascular angina in systemic hypertension: Diagnosis and treatment with enalapril
The American Journal of CardiologyPublished 1 November 1995
Miguel Iriarte, Rosario Caso, Nekane Murga, Marta López de Argumedo, Domingo Sagastagoitia
Citations17
SJR quartileQ2
SJR score0.93
SNIP0.73
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TL;DR
Stress/rest thallium-201 scintigraphy is shown to have a predictive value of 78% for a diagnosis of microvascular disease in hypertensive patients with exertional angina and left ventricular hypertrophy, which correlates well with the decrease in coronary flow reserve in ischemic segments.
Abstract
The causes of hypertensive microvascular ischemia are reviewed along with diagnostic factors. Stress/rest thallium-201 scintigraphy is shown to have a predictive value of 78% for a diagnosis of microvascular disease in hypertensive patients with exertional angina and left ventricular hypertrophy. Lack of isotope uptake at peak stress correlates well with the decrease in coronary flow reserve in ischemic segments, which is 2-3 times lower than in normal subjects. Treatment with enalapril produces regression of left ventricular hypertrophy, normalization of thallium-201 uptake, and an increase in exercise capacity in patients with microvascular angina.
Keywords
ChemistryMedicine
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