Plasma catecholamine levels in the coronary sinus, the left renal vein and peripheral vessels in healthy males at rest and during exercise

Noradrenaline and adrenaline content increased markedly in all samples, especially in the left renal vein and the coronary sinus, and Adrenaline concentration increased significantly in the brachial artery and the femoral vein.

Abstract

Noradrenaline and adrenaline were determined in blood samples from the brachial vein, the brachial artery, the left renal vein and the femoral vein in 6 healthy males (aged 23-35 y). In 3 of the subjects catecholamines were determined also in blood from the coronary sinus. All samples were taken simultaneously in supine postion after 30 min of rest and then in connection with exercise in supine position using a bicycle ergometer, firstly with a work load of 50 W for 9 min and secondly with a work load of 150 W for the same period of time. Under resting conditions the catecholamine levels were about the same at all locations, the mean for noradrenaline being 1.59 nmol/1 with a range of 1.30-2.11 nmol/1 and for adrenaline 0.46 nmol/1 and 0.23-0.65 nmol/1, respectively. At 50 W the noradrenaline concentration increased significantly in the brachial artery, the left renal vein and the femoral vein, whereas adrenaline increased significantly only in the femoral vein. At 150 W the noradrenaline content increased markedly in all samples, especially in the left renal vein (mean increase 13.02 nmol/1) and the coronary sinus (mean increase 13.06 nmol/1). Adrenaline concentration increased significantly in the brachial artery and the femoral vein. At 150 W the mean net output of noradrenaline as estimated from the calculated flows and actual AV-differences amounted to 2.25 nmol/min from the heart and to 0.36 nmol/min from the kidney.