IN VIVO HYPEREXPRESSION OF TRANSFORMING GROWTH FACTOR-??1 IN MICE: STIMULATION BY CYCLOSPORINE1
TransplantationPublished 1 April 1997
Ashwani Khanna, Sandip Kapur, Vijay K. Sharma, Baogui Li, Manikkam Suthanthiran
Citations109
SJR quartileQ1
SJR score1.32
SNIP1.20
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TL;DR
The hypothesis that CsA might function in vivo as an immunosuppressant not only by inhibiting the expression of proinflammatory cytokines (e.g., interleukin 2), but also by stimulating the expressionof TGF-beta1, a potent Immunosuppressive cytokine is advanced.
Abstract
Our observations, together, advance the hypothesis that CsA might function in vivo as an immunosuppressant not only by inhibiting the expression of proinflammatory cytokines (e.g., interleukin 2), but also by stimulating the expression of TGF-beta1, a potent immunosuppressive cytokine. Moreover, prevention of TGF-beta1 hyperexpression might prevent CsA-associated renal fibrosis, as TGF-beta1 is a fibrogenic cytokine.
Keywords
MedicineHealth ProfessionsBiochemistry, Genetics and Molecular Biology
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