Cutaneous T Cell Lymphoma
Medical Clinics of North AmericaPublished 1 January 1986
Robert Knobler, Richard L. Edelson
Citations37
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SJR score1.52
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TL;DR
Cutaneous T cell lymphoma is a malignancy of helper T cells, which have a propensity to infiltrate the skin, and appears to exceed that of Hodgkin's disease, making it the most common lymphoma of adults.
Abstract
Cutaneous T cell lymphoma is a malignancy of helper T cells, which have a propensity to infiltrate the skin. The incidence of the disease appears to exceed that of Hodgkin's disease, making it the most common lymphoma of adults. Advances in our knowledge of the biology of the malignant T cells should facilitate new and more effective forms of treatment.
Keywords
Immunology and MicrobiologyMedicine
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319 Citations1968Lloyd J. Old, Elisabeth Stockert +2 more
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315 Citations1968William C. Roberts, D. Luke Glancy +1 more
The incidence of dyspnea, chest pain, effusions into body cavities, precordial murmurs, ventricular gallops, edema and electrocardiographic disturbances was similar in patients with and without cardiac lymphoma, and these clinical findings most often were the result of mediastinal, pleural or pulmonary lymphomas, anemia, hypoalbuminemia, or an underlying cardiac condition.
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301 Citations1973Jean‐Claude Brouet, Georges Flandrin +1 more
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New England Journal of MedicineBone-Resorbing Activity in Supernatants from Lymphoid Cell Lines
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The LancetRESPONSE OF CUTANEOUS T CELL LYMPHOMA TO THERAPY WITH HYBRIDOMA MONOCLONAL ANTIBODY
261 Citations1981R. A. Miller, Ronald Levy
A murine hybridoma monoclonal anti-T-cell antibody was given to a patient with advanced cutaneous T cell lymphoma and the patient tolerated seventeen treatment courses over ten weeks without symptoms of toxicity.
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240 Citations1981PC Kung, Berger Cl +3 more
BloodThe Ultrastructure of an Abnormal Cell in Sezary’s Syndrome
239 Citations1968Marvin A. Lutzner, Harold W. Jordan
The nucleus of this Sezary cell was strikingly irregular, indented, lobulated, and serpentine, often narrowed to a single row of nuclear particles, and the cytoplasm exhibited no abnormalities.
PubMedElectron-beam therapy for mycosis fungoides: the Stanford University experience.
208 Citations1979Reiner Hoppe, R S Cox +4 more
The use of high-dose electron-beam therapy for mycosis fungoides at Stanford University is reviewed and the development of a rationale for the treatment of patients with all stages of mycotic disease based upon these clincal observations is discussed.
BloodRetroviruses as etiologic agents of some animal and human leukemias and lymphomas and as tools for elucidating the molecular mechanism of leukemogenesis
206 Citations1982RC Gallo, Flossie Wong‐Staal
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CancerPrognostic signs and the management of the mycosis fungoides
199 Citations1973Zvi Fuks, Malcolm A. Bagshaw +1 more
A new staging classification is proposed which provides a rational basis for the introduction of new treatment modalities for the management of mycosis fungoides patients.
Journal of the American Academy of DermatologyPhotochemotherapy for cutaneous T cell lymphoma
185 Citations1984Herbert Hönigsmann, Wilhelm Brenner +3 more
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JNCI Journal of the National Cancer InstituteCytogenetic, Cytophotometric, and Ultrastructural Study of Large Cerebriform Cells of the Sézary Syndrome and Description of a Small-Cell Variant23
179 Citations1973Marvin A. Lutzner, I Emerit +4 more
NatureAntibodies in human sera reactive against an internal structural protein of human T-cell lymphoma virus
177 Citations1981V. S. Kalyanaraman, M. G. Sarngadharan +3 more
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161 Citations1981W. Clark Lambert, Mark Allen Everett
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BloodCutaneous T-cell lymphoma: neoplasm of T cells with helper activity
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159 Citations1980Paul A. Bunn, Mark S. Huberman +11 more
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CancerMycosis fungoides with extracutaneous dissemination: A distinct clinicopathologic entity
158 Citations1974John C. Long, Martín C. Mihm
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156 Citations1963Jerome B. Block, John H. Edgcomb +2 more
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142 Citations1971Marvin A. Lutzner
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The LancetTREATMENT OF CUTANEOUS T-CELL LYMPHOMA (MYCOSIS FUNGOIDES) WITH 13-CIS-RETINOIC ACID
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80 Citations1982Peter C. Nowell̀, J Finan +1 more
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78 Citations1982Carole L. Berger, Susan M. Morrison +8 more
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77 Citations1979Nicholas J. Lowe
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69 Citations1979Gilchrest Ba
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65 Citations1982Lela A. Lee, Karen A. Fritz +3 more
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65 Citations1984R.K. Winkelmann, J.L. Díaz-Pérez +1 more
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57 Citations1976Richard L. Edelson
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Journal of Investigative DermatologyChanges in Melanosome Distribution in Caucasoid Skin Following Topical Application of Nitrogen Mustard
56 Citations1973B. Allen Flaxman, Arthur C Sosis +1 more
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Journal of the American Academy of DermatologyTopical carmustine (BCNU) for mycosis fungoides and related disorders: A 10-year experience
55 Citations1983Herschel S. Zackheim, Ervin H. Epstein +3 more
A 10-year experience in eighty-six patients confirms the effectiveness of topical carmustine (BCNU) in mycosis fungoides, and persistent local therapy cleared deeply infiltrated lesions in some patients.
American Journal of Tropical Medicine and HygieneUpdate: Dermatology in General Medicine
53 Citations1983John H. Arrington
Archives of OphthalmologyMycosis Fungoides
53 Citations1977John L. Keltner
A 58-year-old man with mycosis fungoides was treated with chemotherapeutic agents and radiation for the recurrent cutaneous form of this disease and found the CNS was remarkably free of tumor cells and it was assumed that the radiation and chemotherapy were responsible for this.
PubMedCombination chemotherapy for mycosis fungoides: a Southwest Oncology Group study.
51 Citations1979Grozea Pn, Jones Se +4 more
Combined chemotherapy proved to be effective palliative therapy for advanced mycosis fungoides with an overall objective response rate of 95% with seven patients achieving a complete remission.
Critical Reviews in Oncology/HematologyCutaneous T-cell lymphoma: A review
50 Citations1983C. Winkler, Paul A. Bunn +1 more
Application of prospective staging techniques employing such special procedures as E-rosette cytology, cytogenetics, and electron microscopy in addition to usual light microscopy studies has demonstrated a greater percentage of extracutaneous involvement than otherwise expected.
PubMedTreatment of mycosis fungoides lymphoma: effectiveness of infusions of methotrexate followed by oral citrovorum factor.
50 Citations1978Charles J. McDonald, Joseph Bertino
This regimen consisting of iv infusions of methotrexate (MTX) (60-240 mg/m2) administered sequentially and oral citrovorum factor is concluded to be safe and very effective in the treatment of stages II and III of mycosis fungoides.
British Journal of DermatologyTransient impairment of peripheral blood lymphocyte function during PUVA therapy
47 Citations1979Warwick L. Morison, John A. Parrish +2 more
It is shown that routine PUVA therapy can induce an alteration in immune function but that this alteration is slight and short‐lived.
CancerNormal immunologic reactivity in patients with the lymphoma mycosis fungoides
47 Citations1966W. Kenneth Blaylock, William E. Clendenning +2 more
Patients having the lymphoma, mycosis fungoides, make circulating antibodies to parenterally administered antigens in all stages of the illness, and the titers are normal or slightly reduced in these patients.
British Journal of DermatologyContact urticaria and anaphylactoid reaction induced by topical application of nitrogen mustard
46 Citations1976E. Grunnet
A 36‐year‐old woman and a 16‐year-old boy, both suffering from mycosis fungoides, developed urticaria and an anaphylactoid reaction after topical whole body application of nitrogen mustard.
Archives of DermatologyTreatment of Mycosis Fungoides
45 Citations1982B. Hamminga
In the later stages of MF, in the absence of lymph node or other systemic involvement, electron-beam irradiation seems to be superior in inducing an initial complete remission, but because of the large number of patients who have a relapse after this therapy, it should be followed by topical mechlorethamine therapy.
Archives of DermatologyAlopecia Mucinosa
45 Citations1970Ralph J. Coskey
Following up the clinical course of 50 patients with alopecia mucinosa, the follow-up study in this series revealed no evidence of transformation into lymphoma.
British Journal of DermatologyLight sensitivity in mycosis fungoides
44 Citations1977G Volden, P Thune
Because of suspected photosensitivity, twelve patients suffering from mycosis fungoides have been phototested with various wavebands, finding wavebands situated mostly in the UVA range, but also in the UVB range and in visible light.
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44 Citations1977W.A. van Vloten, A Schaberg +1 more
DNA cytophotometry has value as a supplement to routine morphological histopathology in malignant cutaneous reticulosis in patients with mycosis fungoides and Sézary's syndrome.
Archives of DermatologyRadiation Dermatitis Following Electron Beam Therapy
43 Citations1978Norman M. Price
Ten patients, who had been treated for mycosis fungoides with electron beam radiation ten or more years previously, were examined for signs of radiation dermatitis, and only a few manifested signs of mild chronic changes after having received between 1,000 and 2,800 rads.
RadiologyTotal-Skin Electron-Beam Therapy of Lymphoma Cutis and Generalized Psoriasis: Clinical Experiences and Adverse Reactions
41 Citations1966J. H. Grollman, Stanley M. Bierman +3 more
Low-megavoltage electron therapy proves more advantageous than roentgen rays because the penetration of the electrons can be restricted to the superficial pathologically involved skin, minimizing radiation effects to the underlying normal tissue.
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40 Citations1975THOMAS W. HAUCH, JOHN D. SHELBOURNE +3 more
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40 Citations1979Roenigk Hh
A 3-year followup on ten of 12 patients with mycosis fungoides treated with photochemotherapy (PUVA; psoralens + ultraviolet light) reveals eight patients whose diseases have remained clear while receiving maintenance PUVA.
PubMedCombined therapy for patients with mycosis fungoides.
39 Citations1979Griem Ml, Tokars Rp +4 more
A central nervous system recurrence has been observed in the combined-therapy group and the recurrence-free interval for these three groups correlates with these observations.
Clinical and Experimental DermatologySezary syndrome: transformation to a high grade T-cell lymphoma after treatment with Cyclosporin A
37 Citations1983M. D. Catterall, B. J. Addis +2 more
The abrupt and early change in the course of the disease following therapy with CSA raises the possibility that the drug accelerated or altered the natural history.
DMW - Deutsche Medizinische WochenschriftPhotochemotherapie kutaner Lymphome<sup>*</sup>
36 Citations1977Cornelia Hofmann, G. Burg +2 more
Histological and enzyme-cytochemical studies indicate that the histological features under 8-MOP-UVA treatment correspond to those induced by other forms of treatment: a lose enzyme-Cytochemically negative lymphocytoid infiltrate remaining around blood vessels, after regression of the skin disease.
Archives of DermatologyAmyloid Deposition After Psoriasis Therapy With Psoralen and Long-Wave Ultraviolet Light
36 Citations1979Ira Greene
Histologic examination of skin from 52 patients under continued treatment with methoxsalen and long-wave ultraviolet irradiation (PUVA) disclosed small superficial dermal deposits similar to those of lichen amyloidosus, which should be regarded as a possible complication of PUVA therapy.
Archives of NeurologyMycosis Fungoides Involving the Brain
34 Citations1967M Weber, Malcolm H. McGavran
The occurrence of such central nervous system (CNS) involvement, and the diagnostic problems presented, prompted this report.
Archives of DermatologyChronic Herpes Simplex Infection in Cutaneous T-Cell Lymphomas
34 Citations1980Eric C. Vonderheid
Therapeutically unresponsive erosive or ulcerative lesions caused by the herpes simplex virus developed in five patients with advanced cutaneous T-cell lymphoma and probably was the consequence of immunosuppression resulting from advanced lymphoma or its treatment.
Medical Clinics of North AmericaCutaneous T Cell Lymphoma
33 Citations1982Jennifer Patterson, Richard L. Edelson
Cutaneous T cell lymphoma is a malignancy of helper T cells, which have a propensity to infiltrate the skin, and appears to exceed that of Hodgkin's disease, making it the most common lymphoma of adults.
CancerLeptomeningeal mycosis fungoides
33 Citations1976Walter B. Lundberg, E Cadman +1 more
A leptomeningeal syndrome of blurred vision and papilledema, and confusion progressing to coma, was associated with elevated spinal fluid pressure and abnormal spinal fluid cells morphologically similar to those seen in the Sézary syndrome.
Archives of DermatologyAlopecia Mucinosa and Lymphoma
32 Citations1965Harold Plotnick
Alopecia mucinosa appears to behave differently in that it follows a prolonged chronic course, and of 28 cases in this category four, four developed into either mycosis fungoides or lymphoblastoma.
CancerLaryngeal mycosis fungoides
32 Citations1979Antoinette F. Hood, G Mark +1 more
Mycosis fungoides presented as a tumor of the arytenoid cartilage and epiglottis of the larynx of an 80‐year‐old female and progressed to death over the next two years.
Archives of DermatologyMycosis Fungoides Involving the Brain and Optic Nerves
31 Citations1978David M. Pariser
In a patient with long-standing plaque-stage mycosis fungoides, eye pain, a visual field defect, decreased acuity, and a swollen optic disc developed, a lymphomatous infiltrate consistent with mycotic infiltrate was found at craniotomy and in the optic nerves at autopsy.
Archives of DermatologyMycosis Fungoides of
31 Citations1968Miriam Sandbank
The rare familial occurrence of mycosis fungoides of exceptionally long duration in a brother and sister is reported and the slow development of the condition from subacute dermatitis to the tumoral stage is demonstrated in the illustrations of the skin biopsies.
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