Immunoelectron microscopic localization of amyloid β protein in the diffuse plaques of Alzheimer-type dementia
Brain ResearchPublished 1 February 1990
Haruyasu Yamaguchi, Yoichi Nakazato, Shunsaku Hirai, Mikio Shoji
Citations70
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Intense immunoreaction products, scattered sporadically in the diffuse plaques, were located on small bundles of several amyloid fibrils and/or amorphous materials between amyloids-related cell processes (ARCP), suggesting the importance of ARCP in plaque amyloidal deposits.
Abstract
We examined the ultrastructural localization of beta protein in diffuse plaques of Alzheimer brain by indirect immunoperoxidase technique. Intense immunoreaction products, scattered sporadically in the diffuse plaques, were located on small bundles of several amyloid fibrils and/or amorphous materials between amyloid-related cell processes (ARCP). Deposits of beta protein were also seen on parts of the cell membrane of ARCP, suggesting the importance of ARCP in plaque amyloid deposits.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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