A Method for High-Throughput Screening of Enantioselective Catalysts
Angewandte Chemie International EditionPublished 14 June 1999Open access
Manfred T. Reetz, Michael Becker, Heinz‐Werner Klein, Detlef Stöckigt
Citations338
SJR quartileQ1
SJR score5.55
SNIP2.47
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TL;DR
The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo-enantiomeric products 2 and 3.
Abstract
About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled substrates. The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo-enantiomeric products 2 and 3.
Keywords
Chemistry