Abdominal Obesity, Muscle Composition, and Insulin Resistance in Premenopausal Women
The Journal of Clinical Endocrinology & MetabolismPublished 1 November 2002
Robert Ross, Jennifer Freeman, Robert Hudson, Ian Janssen
Citations214
SJR quartileQ1
SJR score2.18
SNIP1.77
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TL;DR
In conclusion, visceral AT alone is a strong correlate of insulin resistance independent of nonabdominal, abdominal sc AT, muscle composition, and cardiovascular fitness.
Abstract
The independent relationships between visceral and abdominal sc adipose tissue (AT) depots, muscle composition, and insulin sensitivity were examined in 40 abdominally obese, premenopausal women. Measurements included glucose disposal by euglycemic clamp, muscle composition by computed tomography, abdominal and nonabdominal (e.g. leg) AT by magnetic resonance imaging and cardiovascular fitness. Glucose disposal rates were negatively related to visceral AT mass (r = -0.42, P 0.10) related to glucose disposal. Subdivision of abdominal sc AT into anterior and posterior depots did not alter the observed relationships. Further analysis matched two groups of women for abdominal sc AT but with low and high visceral AT. Women with high visceral AT had lower glucose disposal rates compared with those with low visceral AT (P 0.10). In conclusion, visceral AT alone is a strong correlate of insulin resistance independent of nonabdominal, abdominal sc AT, muscle composition, and cardiovascular fitness. Subdivision of abdominal sc AT did not provide additional insight into the relationship between abdominal obesity and metabolic risk.
Keywords
Medicine
Journal of Clinical InvestigationCellular mechanisms of insulin resistance
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It is hypothesized that free fatty acids and testosterone might provide a background not only to a defense reaction and primary hypertension, suggested previously, but also to a defeat reaction, which contributes to an endocrine aberration leading to metabolic aberrations and visceral fat accumulation, which in turn leads to disease.
Diabetes CareScreening for type 2 diabetes.
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762 Citations1995Nicola Abate, Anurag Garg +3 more
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American Journal of Physiology-Endocrinology and MetabolismSubdivisions of subcutaneous abdominal adipose tissue and insulin resistance
539 Citations2000David E. Kelley, F. Leland Thaete +3 more
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Journal of Applied PhysiologyQuantification of adipose tissue by MRI: relationship with anthropometric variables
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Nutrition Research ReviewsEffects of Diet and Physical Activity on Adiposity and Body Fat Distribution: Implications for the Prevention of Cardiovascular Disease
275 Citations1993Jean‐Pierre Després, Benoı̂t Lamarche
Plastic & Reconstructive SurgeryAnatomy of the Subcutaneous Tissue of the Trunk and Lower Extremity
240 Citations1987Barry Markman, Fritz E. Barton
The anatomy of the subcutaneous adipose tissue in the trunk and extremities confirmed Gray's original description of a superficial and deep adipose layer, and observed that the adipose layers are partitioned by a discrete sub cutaneous fascia which fuses with the underlying muscle fascia at particular anatomic locations.
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146 Citations1995Takashi Goto, Tomio Onuma +2 more
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Diabetes CareSeparate Associations Between Visceral and Subcutaneous Adipose Tissue Distribution, Insulin and Glucose Levels in Obese Women
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It is suggested women who have IAF values above 110 cm2 are in jeopardy of possessing elevated CVD risk, and 4- and 6-CVD risk factor analysis and for both pre- and post-menopausal as well as pooled data suggest this.
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It is concluded that the lipolytic rate of the superficial subcutaneous adipose tissue on the anterior abdominal wall is higher than that of the deep subcutaneously adipose tissues on the posterior abdominal wall and that of of the preperitoneal adiposes tissue in the round ligament.
American Journal of Physiology-Endocrinology and MetabolismDeterminants of insulin-stimulated glucose disposal in middle-aged, premenopausal women
41 Citations2001Michael J. Toth, Cynthia K. Sites +3 more
VO2 max was the only variable to enter stepwise regression models as a significant predictor of total and nonoxidative glucose disposal and suggest that it may be a stronger determinant of variation in glucose disposal than total and regional adiposity in nonobese, nondiabetic, premenopausal women.
Medicine & Science in Sports & ExerciseThe swine as a model for studying exercise-induced changes in lipid metabolism
37 Citations1997Gale B. Carey
The swine has many similarities to humans, making it an excellent research model in which to study the role of exercise on lipid metabolism, and recent research suggests that swine adipocyte sensitivity to adenosine, a locally-produced antilipolytic agent, is reduced after exercise treatment.
PubMedDifferential deposition and utilization of backfat layers in swine.
28 Citations1984Mersmann Hj, Leymaster Ka
Backfat layer 1 changed to a small extent compared to layer 2 during depletion, deposition or genetic selection possibly indicating a greater metabolic role in vivo for layer 2.
International Journal of ObesityMeasurement of liver fat by MRI and its reduction by dexfenfluramine in NIDDM
23 Citations1997S. J. Marks, NR Moore +5 more
The Liver Fat Index reduced after 12 weeks therapy with dexfenfluramine suggesting a role for hepatic steatosis in the complex interaction between visceral adipose tissue and insulin sensitivity.