Sex and strain differences in benzodiazepine receptor binding in Roman rat strains
European Journal of PharmacologyPublished 1 February 1982
R.A. Shephard, E. B. Nielsen, P. L. Broadhurst
Citations57
SJR quartileQ1
SJR score1.20
SNIP0.98
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TL;DR
Specific [3H]flunitrazepam binding was determined for five brain regions in both sexes of the three Roman rat strains, with benzodiazepine receptor binding being significantly higher in females in the two cortical areas and the cerebellum, but significantly lower in the striatum and hippocampus.
Abstract
Specific [3H]flunitrazepam binding was determined for five brain regions in both sexes of the three Roman rat strains. Small strain differences and a large Sex-Region interaction were detected, benzodiazepine receptor binding being significantly higher in females in the two cortical areas and the cerebellum, but significantly lower in the striatum and hippocampus. These findings are discussed in the context of sex and strain differences in behavior and benzodiazepine sensitivity.
Keywords
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