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Peroxisome Proliferator-Activated Receptor (PPAR) γ and Retinoid X Receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle

DiabetologiaPublished 6 April 2001Open access
Bong Soo, Theodore P. Ciaraldi, L. Carter, Svetlana E. Nikoulina, Sunder Mudaliar, Ranjan Mukherjee
Citations115
SJR quartileQ1
SJR score3.62
SNIP2.67
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TL;DR

Co-activation of PPAR gamma and RXR results in additive or synergistic effects on glucose and lipid metabolism in skeletal muscle, but unlike troglitazone, LG100268 does not alter expression of its own receptor.

Abstract

Co-activation of PPAR gamma and RXR results in additive or synergistic effects on glucose and lipid metabolism in skeletal muscle, but unlike troglitazone, LG100268 does not alter expression of its own receptor.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology