Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin
Bioorganic & Medicinal ChemistryPublished 12 November 2004
Robert Pajewski, Natasha K Djedovič, Egan Harder, Riccardo Ferdani, Paul H. Schlesinger, George W. Gokel
Citations17
SJR quartileQ2
SJR score0.61
SNIP0.80
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TL;DR
A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics that increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions suggesting the possibility of vesicular fusion.
Abstract
A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics. The compounds prepared increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions. In addition, significantly larger vesicles are observed after exposure to these compounds suggesting the possibility of vesicular fusion.
Keywords
Materials ScienceBiochemistry, Genetics and Molecular Biology
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