The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors
CancerPublished 1 February 1999
Anirban Maitra, Kazuo Yashima, Asha Rathi, Charles F. Timmons, Beverly Barton Rogers, Jerry W. Shay
Citations49
SJR quartileQ1
SJR score2.95
SNIP1.90
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TL;DR
Telomerase is a ribonucleoprotein enzyme associated with cellular immortality that may be useful in determining the biologic potential of a tumor.
Abstract
Increased hTR expression may reflect the potential for aggressive behavior within the spectrum of NTs; conversely, down-regulation of hTR may be useful in identifying subsets with limited capacity for progression and a favorable prognosis.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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