G-proteins as transducers in transmembrane signalling
Progress in Biophysics and Molecular BiologyPublished 16 July 2003
Stefan Offermanns
Citations296
SJR quartileQ1
SJR score1.14
SNIP1.02
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TL;DR
This review summarizes some general aspects of G-protein-mediated signalling and focusses on recent data especially from studies in mutant mice which have elucidated some of the cellular and biological functions of heterotrimeric G-prtoteins.
Abstract
The G-protein-mediated signalling system has evolved as one of the most widely used transmembrane signalling mechanisms in mammalian organisms. All mammalian cells express G-protein-coupled receptors as well as several types of heterotrimeric G-proteins and effectors. G-protein-mediated signalling is involved in many physiological and pathological processes. This review summarizes some general aspects of G-protein-mediated signalling and focusses on recent data especially from studies in mutant mice which have elucidated some of the cellular and biological functions of heterotrimeric G-prtoteins.
Keywords
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OncogeneHeterotrimeric G-protein βγ-dimers in growth and differentiation
196 Citations2001William F. Schwindinger, Janet D. Robishaw
A greater appreciation of the role of the Gβγ-dimer in the regulation of a variety of intracellular effectors, including ion channels, adenylyl cyclase, and phospholipase Cβ is appreciated.
OncogeneRegulation of G proteins by covalent modification
192 Citations2001Catherine A. Chen, David R. Manning
The reversible nature of palmitoylation is intriguing in this regard, as it lends itself to a regulation integrated with the activation state of the G protein.
Proceedings of the National Academy of SciencesPhospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum
192 Citations1998Masanobu Kano, Kouichi Hashimoto +10 more
Results indicate that PLCbeta4 transduces signals that are required for CF synapse elimination in the rostral cerebellum.
The Journal of Experimental MedicinePertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.
187 Citations1985Daniel Goldman, F H Chang +3 more
Pertussis toxin modification of a membrane protein of PMNL analogous to Gi thus simultaneously altersChemotactic receptors and attenuates the changes in cytosolic calcium concentration and PMNL function caused by chemotactic factors.
NatureThe G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain
183 Citations1998Yun Jiang, Wei Ma +4 more
This work shows that G alpha12 binds directly to, and stimulates the activity of, Bruton's tyrosine kinase (Btk) and a Ras GTPase-activating protein, Gap1m, in vitro and in vivo.
Journal of Biological ChemistryGα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways
171 Citations1996Rebecca Hooley, Chun-Yuan Yu +2 more
These findings indicate a new target for Rho-like proteins: the regulation of H exchange and intracellular pH in NHE1 and suggest that a MEKK cascade diverges to regulate effectors other than transcription factors.
The Journal of ImmunologyG(α)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines
169 Citations1997C E Hörnquist, Xuemei Lu +5 more
The mucosal immune system in G(alpha)i2-deficient mice was studied and colitis was associated with increased IgG levels, predominantly IgG2a, in large but not small intestinal secretions, shown by ELISPOT analysis to result from local production within the lamina propria.
Journal of NeuroscienceGα<sub>olf</sub>Levels Are Regulated by Receptor Usage and Control Dopamine and Adenosine Action in the Striatum
167 Citations2001Denis Hervé, Catherine Le Moine +7 more
This study shows that virtually all striatal efferent neurons, identified by the expression of preproenkephalin A, substance P, or D1 receptor mRNA, contained high amounts of Gαolf mRNA and undetectable levels of G αs mRNA, and indicates that G αolf protein levels are regulated through D1and A2A receptor usage.
American Journal of Physiology-Heart and Circulatory PhysiologyCardiomyopathy induced by cardiac Gs alpha overexpression
162 Citations1997Mitsunori Iwase, Masami Uechi +10 more
The concept that chronic sympathetic stimulation over an extended period of time, i.e., over the life of an animal, is deleterious and actually may result in cardiomyopathy is supported.
Circulation ResearchDepressed Heart Rate Variability and Arterial Baroreflex in Conscious Transgenic Mice With Overexpression of Cardiac G <sub>sα</sub>
152 Citations1998Masami Uechi, Kuniya Asai +10 more
The combination of elevated baseline HR, arterial pressure, and respiratory frequency suggests that enhanced beta-adrenergic signaling in TG mice results in reduced HR variability, in terms of both minute-to-minute variability and the lack of circadian variations in HR.
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