CONTROLLED TRIAL OF ACUPUNCTURE FOR DISABLING BREATHLESSNESS
The LancetPublished 1 December 1986
Kim A. Jobst, Klim McPherson, Vivienne Brown, HilaryJ. Fletcher, Peter Mole, Jing Hua Chen
Citations163
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
After three weeks' treatment the traditional-acupuncture group showed significantly greater benefit in terms of subjective scores of breathlessness and six-minute walking distance than the placebo group.
Abstract
In a randomised controlled trial, twelve matched pairs of patients with chronic obstructive pulmonary disease received traditional Chinese acupuncture or placebo acupuncture. After three weeks' treatment the traditional-acupuncture group showed significantly greater benefit in terms of subjective scores of breathlessness and six-minute walking distance. Objective measures of lung function were unchanged in either group. Whether these differences are mediated by endogenous opiate and/or peptide release remains speculative.
Keywords
MedicineNeuroscience
NatureIdentification of two related pentapeptides from the brain with potent opiate agonist activity
3,786 Citations1975Joel W. Hughes, Terry Smith +4 more
The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl–Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
BMJTwo-, six-, and 12-minute walking tests in respiratory disease.
1,656 Citations1982R. J. A. Butland, J. A. Pang +3 more
Over the ensuing seven months she had three more clinical relapses, each accompanied by reappearance in the stools of either the organism or its cytotoxin, or both, and maintenance treatment with oral vancomycin 125 mg eight-hourly was begun.
NatureBenzodiazepine receptors in rat brain
1,453 Citations1977Richard F. Squires, Claus Bræstrup
Experiments suggest that another important group of psychoactive drugs, the benzodiazepines, bind to specific receptors on the membranes of rat brain cells, and this suggests that there may be an unknown endogenous neurotransmitter which is the natural ligand for the Benzodiazepine receptor.
BMJTwelve-minute walking test for assessing disability in chronic bronchitis.
747 Citations1976C R McGavin, Suyashvi Gupta +1 more
The distance covered in 12 minutes' walking was used to test exercise tolerance in chronic bronchitis and bore a poor relation to the forced expiratory volume in 1 second but a significant relation toThe forced vital capacity and the maximum oxygen consumption and ventilation on a bicycle ergometer.
The Annual Review of Pharmacology and ToxicologyNeurochemical Basis of Acupuncture Analgesia
588 Citations1982Ji‐Sheng Han, Lars Terenius
A review on acupuncture and its neurochemical basis and much of the work in this field has been published in periodicals not easily accessible to the general scientific community for linguistic or other reasons, it is found it necessary to limit this review to studies of acupuncture for the relief of pain.
BMJDyspnoea, disability, and distance walked: comparison of estimates of exercise performance in respiratory disease.
442 Citations1978C R McGavin, M Artvinli +2 more
The scatter of results was such that exercise performance could not usefully be predicted from the respiratory function values or from subjective assessments, and simple exercise tests are an essential part of assessing disability and response to treatment in patients with respiratory impairment.
PainThe evaluation of therapeutic acupuncture: Concepts and methods
233 Citations1986Charles Vincent, Phil Richardson
This paper introduces some basic concepts concerning acupuncture and considers the standards by which clinical studies of acupuncture should be evaluated, and considers certain key methodological issues with special attention to the difficulties of defining suitable control groups.
The Annual Review of Pharmacology and ToxicologyBiology of Opioid Peptides
187 Citations1979Ann Beaumont, Joel W. Hughes
At present only three endogenous opiate peptides have been identified that have any claim to a physiological function and in the absence of structural and chemical identification it is impossible to assess their significance or biological function.
American Review of Respiratory DiseaseBreathlessness and Exercise in Patients with Cardiorespiratory Disease
165 Citations1986Paul J. LeBlanc, Dennis Bowie +3 more
Using multifactorial analysis, the perception of breathlessness was significantly related to the Ppl, inspiratory flow rate, VT/VC, TI/Ttot, and fb, which explained 69% of the variance, with no single factor being identified as uniquely predominant.
PubMedSuperficial acupuncture in the relief of chronic low back pain.
162 Citations1983Alexander Macdonald, K D MacRae +2 more
A single-blind, randomised, placebo-controlled trial of superficial acupuncture in the treatment of low back pain showed significant superiority of acupuncture over placebo.
QJMDISPROPORTIONATELY SEVERE BREATHLESSNESS IN CHRONIC BRONCHITIS
142 Citations1969B. H. Burns, J. B. L. Howell
Clinical ScienceBreathlessness during different forms of ventilatory stimulation: a study of mechanisms in normal subjects and respiratory patients
138 Citations1985L. Adams, R. Lane +3 more
The results suggest that the intensity of breathlessness depends on the level of effective reflex stimulation of the respiratory-related neurones in the medulla, and cannot be explained solely in terms of perception of afferent neural information arising from either chemoreceptors or respiratory mechanoreceptors.
The American Journal of Chinese MedicineThe Acupunture Treatment of Low Back Pain: A Randomized Controlled Study
127 Citations1980Ralph M. Coan, Grace Ching Yin Wong +5 more
The acupuncture treatment situation was beneficial to the majority of people with how back pain and this was shown by the use of the short-term and long-term controls.
Journal of Neurology Neurosurgery & PsychiatryAcupuncture versus medical treatment for migraine and muscle tension headaches.
116 Citations1984Li‐Cher Loh, P W Nathan +2 more
In 48 patients with chronic migraine and muscle tension headaches, a comparison was made between a prophylactic course of acupuncture and of medical treatment; a beneficial response to acupuncture was more likely when the patient had local tender muscular points.
QJMDiazepam in the Treatment of Dyspnoea in the ‘Pink Puffer’ Syndrome
100 Citations1980P Mitchell-Heggs, Kevin Murphy +5 more
The use of diazepam to treat dyspnoea in this syndrome is safe in the absence of any acute infection, and there were no changes in resting blood gases.
NeuropharmacologyAcupuncture mechanisms in rabbits studied with microinjection of antibodies against β-endorphin, enkephalin and substance P
79 Citations1984Han Jisheng, Xie Guo-xi +3 more
The demonstration of site specificity of the neuropeptides in mediating analgesia induced by electroacupuncture supports the validity of this experimental approach.
The LancetACUPUNCTURE IN GASTROSCOPY
50 Citations1978Antony Cahn, Pascale Carayon +2 more
The analgesic effect of acupuncture was evaluated by a double-blind controlled trial in 90 patients undergoing gastroscopy and the endoscopy was much easier and better tolerated after real acupuncture had been performed.
ThoraxPsychological changes and improvement in chronic airflow limitation after corticosteroid treatment.
13 Citations1984David M. Mitchell, P. Gildeh +3 more
It is suggested that in patients with chronic obstructive lung disease significant psychological changes are no more likely to follow treatment with a corticosteroid than treatment withA placebo and that physiological improvement after corticosticosteroid treatment is not tied to psychological changes.