Readily Available Biaryl P,N Ligands for Asymmetric Catalysis
Angewandte Chemie International EditionPublished 10 November 2004Open access
Thomas F. Knöpfel, Patrick Aschwanden, Takashi Ichikawa, Takumi Watanabe, Erick M. Carreira
Citations374
SJR quartileQ1
SJR score5.55
SNIP2.47
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Abstract
A short and modular synthesis of novel P,N ligands (pinap; see scheme; X=O or NH) is presented. A covalently bound chiral group allows the separation of the atropisomeric diastereomers, thus avoiding resolution involving chiral Pd–amine complexes. The utility of the ligands is demonstrated for three reactions catalyzed by different transition metals; in each case products are obtained with high enantiomeric excess (up to 99 % ee).
Keywords
Chemistry
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