Brugada Electrocardiographic Pattern Induced by Cocaine Toxicity

Annals of Emergency MedicinePublished 24 May 2007

Vikhyat S. Bebarta, Shane Summers

DOI10.1016/j.annemergmed.2007.01.027

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Citations46

SJR quartileQ1

SJR score0.84

SNIP1.55

Abstract

Brugada syndrome is associated with sudden death and is mediated by a genetic myocardial sodium channel dysfunction. 1 Antzelevitch C. Brugada P. Borggrefe M. et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005; 111: 659-670 Crossref PubMed Scopus (1423) Google Scholar Brugada electrocardiographic pattern can occur after ingestion of medications with Type IA antidysrhythmic properties. 1 Antzelevitch C. Brugada P. Borggrefe M. et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005; 111: 659-670 Crossref PubMed Scopus (1423) Google Scholar We report a case of Brugada electrocardiographic pattern in a cocaine toxic patient whose electrocardiogram (ECG) was initially interpreted as an acute ST elevation myocardial infarction.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology

CirculationBrugada Syndrome: Report of the Second Consensus Conference

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The present report elaborates further on the diagnostic criteria and examines risk stratification schemes and device and pharmacological approaches to therapy on the basis of the available clinical and basic science data.

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Journal of ElectrocardiologyAborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion

122 Citations2001J. Ortega-Carnicer, Juan Bertos-Polo +1 more

A patient with massive cocaine ingestion who developed psychomotor agitation and generalized seizures followed by asystolic cardiac arrest is reported, and the electrocardiogram showed accelerated junctional rhythm at 85 beats/min resembling the Brugada syndrome.

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A healthy young man with a normal baseline ECG in whom a transient Brugada pattern was observed repeatedly after recreational cocaine use is described, illustrating that, in susceptible individuals, cocaine may provoke the BrugADA sign.

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103 Citations1997William Kerns, Lee Garvey +1 more

It is reported that three cases of acute cocaine intoxicating during which patients developed wide complex dysrhythmia consistent with sodium channel poisoning resolved following intravenous bicarbonate therapy directed at reversing sodium channel blockade.

The American Journal of Emergency MedicinepH-dependent cocaine-induced cardiotoxicity

66 Citations1999Richard Y. Wang

Treatment of the patients with hyperventilation, sedation, active cooling, and sodium bicarbonate infusion led to the normalization of their blood pHs and reversal of their cardiac conduction disorders.