Recognition of protein coding regions in DNA sequences
Nucleic Acids ResearchPublished 1 January 1982Open access
James W. Fickett
Citations908
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TL;DR
The test has been thoroughly proven on 400,000 bases of sequence data: it misclassifies 5% of the regions tested and gives an answer of "No Opinion" one fifth of the time.
Abstract
We give a test for protein coding regions which is based on simple and universal differences between protein-coding and noncoding DNA. The test is simple enough to use without a computer and is completely objective. The test has been thoroughly proven on 400,000 bases of sequence data: it misclassifies 5% of the regions tested and gives an answer of "No Opinion" one fifth of the time. We predict some new coding and noncoding regions in published sequences.
Keywords
Biochemistry, Genetics and Molecular Biology
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