Immunotherapy and chemotherapy — a practical partnership
Nature reviews. CancerPublished 20 April 2005
Richard Lake, Bruce Robinson
Citations645
SJR quartileQ1
SJR score24.38
SNIP11.13
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
How recent data have altered the way the authors understand how dying tumour cells, particularly those killed by chemotherapy, engage with antitumour immune responses has significant implications for the development of new protocols combining chemotherapy with immunotherapy.
Abstract
This article discusses how recent data have altered the way we understand how dying tumour cells, particularly those killed by chemotherapy, engage with antitumour immune responses. These data have significant implications for the development of new protocols combining chemotherapy with immunotherapy, indicating an exciting potential for therapeutic synergy with general applicability to many cancer types.
Keywords
Immunology and MicrobiologyMedicine
British Journal of CancerApoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
15,636 Citations1972J. F. R. Kerr, A H Wyllie +1 more
Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Annual Review of ImmunologyTolerance, Danger, and the Extended Family
4,711 Citations1994Polly Matzinger
The possibility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues is discussed.
Developmental CellDevelopment by Self-Digestion
3,643 Citations2004Beth Levine, Daniel J. Klionsky
This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy.
ScienceCancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes
2,812 Citations2002Mark E. Dudley, John R. Wunderlich +17 more
The adoptive transfer of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen resulted in the persistent clonal repopulation of T cells in cancer patients, leading to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction.
NatureSocial controls on cell survival and cell death
2,641 Citations1992Martin Raff
For some mammalian cells, programmed death seems to occur by default unless suppressed by signals from other cells, so dependence on specific survival signals provides a simple way to eliminate misplaced cells, for regulating cell numbers and, perhaps, for selecting the fittest cells.
ScienceDecoding the Patterns of Self and Nonself by the Innate Immune System
2,160 Citations2002Ruslan Medzhitov, Charles A. Janeway
The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self.
Nature ImmunologySelective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
1,817 Citations2003Susan M. Kaech, Joyce T. Tan +4 more
Increased expression of the interleukin 7 receptor α-chain (IL-7Rα) identifies the effector CD8 T cells that will differentiate into memory cells, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization.
NatureMolecular identification of a danger signal that alerts the immune system to dying cells
1,663 Citations2003Yan Shi, James E. Evans +1 more
Uric acid stimulates dendritic cell maturation and, when co-injected with antigen in vivo, significantly enhances the generation of responses from CD8+ T cells, and have important implications for vaccines, autoimmunity and inflammation.
Journal of Immunological MethodsDetermination of lymphocyte division by flow cytometry
1,655 Citations1994A. Bruce Lyons, Christopher R. Parish
A new technique in which an intracellular fluorescent label is divided equally between daughter cells upon cell division is presented, applicable to in vitro cell division, as well as in vivo division of adoptively transferred cells, and can resolve multiple successive generations using flow cytometry.
NatureCorpse clearance defines the meaning of cell death
1,523 Citations2000John Savill, Valerie A. Fadok
Appoptosis marks unwanted cells with 'eat me' signals that direct recognition, engulfment and degradation by phagocytes allow scavenger cells to confer meaning upon cell death.
Immunological ReviewsInnate immune recognition: mechanisms and pathways
1,486 Citations2000Ruslan Medzhitov, CharleS. Jr Janeway
The Journal of Experimental MedicineConsequences of Cell Death
1,360 Citations2000Birthe Sauter, Matthew L. Albert +4 more
It is demonstrated here that optimal cross-presentation of antigens from tumor cells requires two steps: phagocytosis of apoptotic cells by immature DCs, which provides antigenic peptides for major histocompatibility complex class I and class II presentation, and a maturation signal that is delivered by exposure to necrotic tumor cells, their supernatants, or standard maturation stimuli, e.g., monocyte-conditioned medium.
Current Opinion in Cell BiologyDeath by design: apoptosis, necrosis and autophagy
1,342 Citations2004Aimee L. Edinger, Craig B. Thompson
This work has helped to define the function of and mechanism for programmed necrosis and the role of autophagy in cell survival and suicide and to suggest a possible mechanism for non-apoptotic death.
Immunology TodayThe immune system evolved to discriminate infectious nonself from noninfectious self
1,325 Citations1992Charles A. Janeway
It is argued that the requirement for two signals to initiate the adaptive immune response may reflect the evolutionary history of host defences.
Experimental Cell ResearchInduction of Apoptosis by Cancer Chemotherapy
1,253 Citations2000Scott H. Kaufmann, William C. Earnshaw
The two prototypic death pathways are described, current understanding of the role of the two pathways in chemotherapy-induced apoptosis is summarized, and the implications of these studies for mechanisms of resistance to chemotherapeutic agents are discussed.
The Journal of Experimental MedicineThe Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells
1,169 Citations2000Ralph M. Steinman, Shannon J. Turley +2 more
OncogeneA decade of caspases
1,095 Citations2003Alexei Degterev, Michael Boyce +1 more
A large number of caspases from the cysteine proteases family play important roles in regulating apoptosis, and the mechanisms by which they mediate apoptosis and a variety of physiological and pathological processes are studied.
Nature reviews. CancerPathways of apoptotic and non-apoptotic death in tumour cells
1,034 Citations2004Hitoshi Okada, Tak W. Mak
The mitotic-checkpoint molecule survivin — the inactivation of which induces the death of p53-deficient cells by mitotic catastrophe — is of particular interest.
Nature MedicineInvolvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells
997 Citations1996Claudia Friesen, Ingrid Herr +2 more
It is described that doxorbicin induces apoptosis via the CD95/CD95–L system in human leukemia T–cell lines and this finding provides a new molecular insight into resistance and sensitivity toward chemotherapy in malignancies.
Cell Death and DifferentiationRole of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
984 Citations2004Takao Kanzawa, Isabelle M. Germano +4 more
Application of an autophagy inhibitor that works after the association of LC3 with autophagosome membrane, such as bafilomycin A1, is expected to enhance the cytotoxicity of TMZ for malignant gliomas.
Cellcdc25+ functions as an inducer in the mitotic control of fission yeast
979 Citations1986Paul Russell, Paul Nurse
Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic inhibitor wee1+, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.
Immunology TodayA very high level of crossreactivity is an essential feature of the T-cell receptor
947 Citations1998Don Mason
It is argued that a comprehensive response to foreign antigens requires that T cells are widely crossreactive, such that one cell reacts productively with approximately 10 6 different MHC-associated minimal peptide epitopes.
Annual Review of ImmunologyLIGAND RECOGNITION BY αβ T CELL RECEPTORS
931 Citations1998Mark M. Davis, J. Jay Boniface +5 more
An analysis of the highly diverse CDR3 loops found in all antigen receptor molecules is concluded and it is suggested that such regions form the core of both TCR and antibody specificity.
European Journal of ImmunologyCD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
868 Citations2004François Ghiringhelli, Nicolas Larmonier +8 more
It is shown here that PROb tumor volume is correlated with an expansion of CD4+CD25+ regulatory T’lymphocytes in lymphoid tissues and the interest of regulatory T'cell depletion to sensitize established tumors to immunotherapy is pursued.
Annual Review of ImmunologyInteraction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses
850 Citations2002Pramod K. Srivastava
Results point to a key role of heat shock proteins in fundamental immunological phenomena such as activation of antigen presenting cells, indirect presentation (or cross-priming), and chaperoning of peptides during antigen presentation.
PubMedMitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.
783 Citations1996M A Jordan, K Wendell +4 more
The results support the hypothesis that the most potent chemotherapeutic mechanism of paclitaxel is kinetic stabilization of spindle microtubule dynamics.
Cancer Immunology ImmunotherapyA listing of human tumor antigens recognized by T cells
692 Citations2001Nicolina Renkvist, Chiara Castelli +2 more
Complete list of abbreviations of tumor antigens 707-AP 707 alanine proline-AFP alpha (α)-fetoprotein-ART-4 adenocarcinoma antigen recognized by T cells 4 BAGE B antigen-β-catenin/m β-catensin/mutated-Bcr-abl breakpoint cluster region-Abelson.
Proceedings of the National Academy of SciencesAntigen-independent memory CD8 T cells do not develop during chronic viral infection
486 Citations2004E. John Wherry, Daniel L. Barber +3 more
It is found that during a chronic infection virus-specific CD8 T cells failed to acquire the cardinal memory T cell property of long-term antigen-independent persistence, which raises concerns about using vaccines that may persist and suggests that there may be limitations and challenges in designing effective immunological interventions for the treatment of chronic infections and tumors.
The Journal of ImmunologyInduction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells
469 Citations2003Anna K. Nowak, Richard Lake +6 more
T tumor cell apoptosis in vivo neither sequesters tumor Ags nor cross-tolerizes tumor-specific CD8 cells, which has fundamental consequences for the development of tumor immunotherapy protocols and for understanding T cell reactivity to tumors and the in vivo immune responses to apoptotic cells.
Cancer Immunology ImmunotherapyA listing of human tumor antigens recognized by T cells: March 2004 update
460 Citations2004Luisa Novellino, Chiara Castelli +1 more
This review provides a comprehensive list of human tumor antigens as reported in the literature updated at Feburary 2004, and is a database tool for clinicians, scientists and students who have an interest in the field of tumor immunology and immunotherapy.
Nature reviews. ImmunologyCross-presentation in viral immunity and self-tolerance
455 Citations2001William R. Heath, Federico Carbone
New evidence indicates that dendritic cells have a specialized capacity to process exogenous antigens into the MHC class I pathway, which provides the immune system with an important mechanism for generating immunity to viruses and tolerance to self.
PubMedSynergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors.
416 Citations2003Anna K. Nowak, Bruce Robinson +1 more
Evidence is provided that chemotherapy has the capacity to augment cellular antitumor immunity, a finding with wider implications for the management of treatment-resistant solid tumors.
The Journal of ImmunologyDifferential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases
366 Citations2001Valerie A. Fadok, Donna L. Bratton +2 more
It is suggested that anti-inflammatory signals can be given by PtdSer-containing cell membranes, whether from early apoptotic, late apoptotic or lysed cells, but can be overcome by proteases liberated during lysis.
The Journal of ImmunologyDifferentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division
365 Citations1998Stephan Oehen, Karin Brduscha‐Riem
In this study, in vitro and in vivo the differentiation of naive CTL into effector and memory CTL as a function of cell division using lymphocytic choriomeningitis virus-specific TCR-transgenic spleen cells labeled with the vital dye carboxyfluorescein diacetate, succinimidyl ester is investigated.
Journal of Immunological MethodsQuantification of antigen specific CD8+ T cells using an ELISPOT assay
364 Citations1995Yasushi Miyahira, Kenichiro Murata +5 more
This ELISPOT assay can be performed with spleen cells from immunized mice, and provide the precise number of antigen specific CD8+ T cells present in mixed lymphocyte populations, and is more sensitive than the chromium-51 release assay, and much simpler than the conventional precursor frequency analysis.
Seminars in Cancer BiologyCell surface Death Receptor signaling in normal and cancer cells
292 Citations2003Nesrin Özören, Wafik S. El‐Deiry
The extrinsic cell death pathway is initiated upon ligand-receptor interactions at the cell surface including FASligand-FAS/APO1, TNF-TNF receptors, and TRAIL-TRAIL receptors.
ImmunityTranscriptional Suppression of Interleukin-12 Gene Expression following Phagocytosis of Apoptotic Cells
274 Citations2004Sun Jung Kim, Keith B. Elkon +1 more
It is demonstrated that cell-cell contact with apoptotic cells is sufficient to induce profound inhibition of IL-12 production by activated macrophages or by treatment with phosphatidylserine, and a novel zinc finger nuclear factor, named GC binding protein (GC-BP), is identified and reported on.
PubMedGemcitabine exerts a selective effect on the humoral immune response: implications for combination chemo-immunotherapy.
241 Citations2002Anna K. Nowak, Bruce Robinson +1 more
Gemcitabine does not appear to be detrimental to specific antitumor cellular immunity and may be useful in combination chemo-immunotherapy protocols, in contrast, vaccination protocols requiring a humoral immune response for maximal efficacy may be compromised in patients treated with gem citabine.
Current Opinion in ImmunologyDevelopment and function of CD25+CD4+ regulatory T cells
217 Citations2004Zoltán Fehérvári, Shimon Sakaguchi
The essential role played by CD25(+)CD4(+) regulatory T cells (T(R) cells) in the control of physiological as well as pathological immunity is now well established, but many aspects of their biology still remain unclear.
Annual Review of ImmunologyPeripheral T Cell Tolerance
217 Citations1992J. F. A. P. Miller, Grant Morahan
Tolerance in the T-cell repertoire is achieved not only by intrathymic deletion of self-reactive clones but also by several postthymic mechanisms.
The FASEB JournalLife after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth
210 Citations2004Heiko Golpon, Valerie A. Fadok +6 more
It is shown that the phagocytosis of apoptotic Jurkat T cells by mouse epithelial cells and peritoneal macrophages leads to the secretion of growth and survival factors by phagocytes that represents a new form of life‐promoting cell‐cell interaction.
NatureReversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity
208 Citations1974L. Polák, J.L. Turk
It is reported that a similar state of unresponsiveness to the dinitrophenyl group in guinea pigs can be broken by treatment with cyclophosphamide (CY) just before sensitisation and this is associated with the return of the ability of T cells to proliferate in the draining lymph node as part of the immune response.
BloodCross-presentation of tumor antigens by bone marrow–derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression
208 Citations2001Eduardo M. Sotomayor, Ivan Borrello +5 more
It is unambiguously demonstrated that in the absence of host APC presentation, tumor-specific T cells remained functional, even in the setting of antigen expressed by B-cell lymphomas residing in secondary lymphoid tissues.
LIGAND RECOGNITION BY T CELL RECEPTORS
196 Citations1998Mark M. Davis, J. Jay Boniface +5 more
An analysis of the highly diverse CDR3 loops found in all antigen receptor molecules is concluded and it is suggested that such regions form the core of both TCR and antibody specificity.
BloodStressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells
170 Citations2002Hanping Feng, Yi Zeng +2 more
The data indicate that stressed apoptotic tumor cells are capable of providing the necessary danger signals, likely through increased surface expression of heat shock proteins (HSPs), resulting in activation/maturation of dendritic cells and, ultimately, the generation of potent antitumor T-cell responses.
The Journal of ImmunologyAntigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens
169 Citations1999David J. Morgan, Huub T. C. Kreuwel +1 more
There is a direct correlation between the amount of HA expressed in the periphery, and both the degree of T cell proliferation in the pancreatic lymph nodes and the rate of tolerance of HA-specific CD8+ T cells, which strongly supports the hypothesis that activation of T cells through cross-presentation of peripheral Ags in a noninflammatory environment is an important part of the normal mechanism of tolerance to Ags.
Advances in pharmacologyChemotherapy-Induced Apoptosis
165 Citations1997Peter W. Mesner, I. Imawati Budihardjo +1 more
This chapter focuses on the current state of knowledge regarding the mechanisms by which programmed cell death (PCD) is triggered by cancer chemotherapeutic agents and discusses a series of outstanding questions that require further investigation if the recent observations are to be translated into more successful cancer chemotherapy.
Current Opinion in ImmunologyBuilding better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity
151 Citations2000Nicholas P. Restifo
The molecular machinery at the nexus of apoptosis and inflammation includes caspase-1 --an activator of IL-1beta and IL-18 - as well as the double-stranded-RNA-dependent protein kinase pathway and RNaseL pathway, which are key effectors of antiviral immunity.
Nature BiotechnologyTargeted antigen delivery to antigen–presenting cells including dendritic cells by engineered Fas-mediated apoptosis
127 Citations2000Michael A. Chattergoon, J. Joseph Kim +7 more
This work engineered Fas-mediated apoptotic death of antigen-bearing cells in vivo by co-expressing the immunogen and Fas in the same cell, which led to enhanced antigen-specific CTLs, and the elaboration of T helper-1 (Th1) type cytokines and chemokines.
Nature BiotechnologyApoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases
124 Citations2001Shin Sasaki, Rama Rao Amara +3 more
It is shown that antigen-laden apoptotic bodies created by vectors co-expressing influenza virus hemagglutinin or nucleoprotein (NP) genes and mutant caspase genes markedly increased T-cell responses.
PubMedT-cell receptor transgenic analysis of tumor-specific CD8 and CD4 responses in the eradication of solid tumors.
123 Citations1999Amanda L. Marzo, Richard Lake +2 more
It is shown that tumor-specific CD4 cells, when CTL numbers are suboptimal, greatly enhance the eradication of tumor, confirming the importance of antigen-presenting cell presentation of tumor antigens to class II-restricted cells.
PubMedExtra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens.
120 Citations2003Alex G. Cuenca, Fengdong Cheng +8 more
The findings of early development of antigen-specific T-cell unresponsiveness mediated by BM-derived antigen-presenting cells provide a plausible explanation for the failure of the immune system to reject antigenic solid tumors in vivo and have identified a barrier that, if appropriately manipulated, may lead to approaches to effectively harness theimmune system against solid malignancies.
Immunologic ResearchHuman tumor antigens recognized by T-cells
118 Citations1997Yutaka Kawakami, Steven A. Rosenberg
Many human tumor antigens recognized by autologous T-cells have now been identified, found to be nonmutated and mutated peptides derived from various self proteins as well as viral proteins.
Trends in Molecular MedicineDanger signals: a time and space continuum
115 Citations2004Mojca Škoberne, Anne‐Sophie Beignon +1 more
The significance and principle of action of these molecules in alerting the immune system to dying cells are discussed and it is proposed that, in sterile injury, they have a primary initiating role, whereas in the presence of pathogens, initiation is caused by pathogen-associated molecules.
The Journal of Experimental MedicineT-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites.
101 Citations1977R J North, D P Kirstein
It was concluded that systemic macrophage activation was the consequence of the generation of T-cell-mediated immunity to the progressively growing tumor, and that this not only gave the host the capacity to inhibit the growth of unrelated tumors, but also to protect itself against microbial infection.
Breast Cancer ResearchDoxorubicin and paclitaxel enhance the antitumor efficacy of vaccines directed against HER 2/neuin a murine mammary carcinoma model
93 Citations2004Yeşim Eralp, Xiaoyan Wang +4 more
The results demonstrated that doxorubicin and paclitaxel, commonly used chemotherapeutic agents for the treatment of breast cancer, when used at immunomodulating doses augmented the antitumor efficacy of gene vaccines directed against HER2/neu.
Cancer Immunology ImmunotherapyTreatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8 + cytotoxic T lymphocytes
92 Citations2001Elke S. Bergmann‐Leitner, Scott I. Abrams
Certain anti-neoplastic agents may display unique immunoregulatory properties that facilitate human colon carcinoma death by engaging the lytic capacity of Ag-specific CTL, which may have implications for chemoimmunotherapy strategies.
Leukemia & lymphoma/Leukemia and lymphomaApoptotic Cell Death During Treatment of Leukemias
92 Citations1994Xun Li, Jianping Gong +4 more
The data show that the response to treatment with a variety of drugs, in terms of induction of apoptosis, can be conveniently measured, and the prognostic value of the apoptotic index is being estimated for each type of leukemia, in the ongoing prospective studies.
Journal of Leukocyte BiologyDelayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells
86 Citations1999Patrizia Rovere, Maria Grazia Sabbadini +6 more
In vitro data suggesting that the number of apoptotic cells that die at a given time influences DC maturation and therefore their ability to uptake antigens from apoptotic Cells and cross‐activate T lymphocytes are discussed.
VaccineApoptosis is essential for the increased efficacy of alphaviral replicase-based DNA vaccines
78 Citations2003Wolfgang W. Leitner, Leroy N. Hwang +4 more
Data show for the first time that the induction of apoptotic cell death of transfected cells in vivo is required for the increased effectiveness of replicase-based vaccines, and provides an explanation for the paradoxical observation that replicasing DNA vaccines are much more immunogenic than conventional constructs despite reduced antigen production.
LeukemiaBcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome
77 Citations1999GS Salomons, LA Smets +7 more
The results indicate that the anti-proliferative function of BCl-2 dominates its anti-apoptotic function in ALL, but neither Bcl-2 nor the B cl-2 family members gained prognostic information in the risk-adapted protocol ALL-7.
Journal of Neurosurgery PediatricsTransient local response and persistent tumor control in a child with recurrent malignant glioma: treatment with combination therapy including dendritic cell therapy
75 Citations2004Steven De Vleeschouwer, Frank Van Calenbergh +8 more
The potential of vaccination with DCs loaded with crude tumor homogenate as adjuvant therapy to induce prolonged tumor control of malignant glioma and the objective noninvasively monitored immune response against infiltrating tumor cells is illustrated.
The Journal of ImmunologyTreatment of Melanoma with 5-Fluorouracil or Dacarbazine In Vitro Sensitizes Cells to Antigen-Specific CTL Lysis through Perforin/Granzyme- and Fas-Mediated Pathways
75 Citations2004Sixun Yang, Frank G. Haluska
The findings demonstrate that cytotoxic drug-mediated sensitization primes both perforin/granzyme and Fas-mediated killing by melanoma-specific CTL, and provides experimental basis for understanding cytot toxic and immunologic therapeutic synergy in melanoma.
International Journal of CancerA role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes
65 Citations2001Giuliana Cassinelli, Rosanna Supino +5 more
Comparisons of cellular response to taxanes and the novel analog IDN 5109 in the parental cell line, containing wild‐type p53 and its cisplatin‐resistant p53 mutant subline, suggest that loss of p53‐dependent post‐mitotic checkpoint results in a different time‐course of taxane‐induced cell death following DNA reduplication.
The Journal of ImmunologyIn Vivo Cross-Presentation of a Soluble Protein Antigen: Kinetics, Distribution, and Generation of Effector CTL Recognizing Dominant and Subdominant Epitopes
64 Citations2000Delia J. Nelson, Christine Bundell +1 more
Analysis of functional in vivo CTL responses demonstrated that, in the presence of strong ongoing responses to the dominant peptide, lytic activity of CTL directed at weaker epitopes is undetectable.
The Journal of ImmunologyCutting Edge: Tumor-Specific CTL Are Constitutively Cross-Armed in Draining Lymph Nodes and Transiently Disseminate to Mediate Tumor Regression following Systemic CD40 Activation
58 Citations2004Philip A. Stumbles, Robyn Himbeck +4 more
Data indicate that CD40 activation enhances the peripheral survival of constitutively cross-armed CTL and that persistent CD4+ T cell signals are required for their long-term activity.
The Journal of ImmunologyBcl-2-Mediated Inhibition of Apoptosis Prevents Immunogenicity and Restores Tumorigenicity of Spontaneously Regressive Tumors
49 Citations1998Bernard Bonnotte, Nathalie Favre +5 more
Observations indicate that tumor cell apoptosis may contribute to immunogenicity in rats with rat colon carcinoma.
Cerebrovascular DiseasesIs Ultrasound Examination Sufficient in the Evaluation of Patients with Internal Carotid Artery Severe Stenosis or Occlusion?
39 Citations2003Maurizio Paciaroni, Valeria Caso +8 more
Evaluated how angiography-obtained information on intracranial arteries affects the treatment decision in patients with 70–99% ICA stenosis to evaluate when a symptomatic ICA occlusion shown by ultrasound could actually be a patent artery and therefore benefit from CE.
PubMedThe differential influence of allogeneic tumor cell death via DNA damage on dendritic cell maturation and antigen presentation.
30 Citations2003Ariel N Rad, Gabriele Pollara +4 more
This is the first study that shows that DCs respond differentially to killed tumor cells, depending upon the mechanism of DNA damage and consequent cell death, and supports the hypothesis that the activating effects of tumor cells are linked to the nature of the DNA damage.
Journal of Infection and ChemotherapyAn analysis of the therapeutic efficacy of protracted infusion of low-dose 5-fluorouracil and cisplatin in advanced gastric cancer
21 Citations2000R. Kim, Naoki Nishimoto +3 more
The results indicate that the protracted infusion of low-dose FP could be a useful regimen for patients with advanced gastric cancer, in terms of the high response rate and low toxi-city, possibly leading to the prolongation of survival and improvement in the quality of life.
Journal of ChemotherapyDNA Repair Enzymes and Cytotoxic Effects of Temozolomide: Comparative Studies Between Tumor Cells and Normal Cells of the Immune System
11 Citations2003Elena Pagani, Rita Pepponi +10 more
Strategies aimed at modulating OGAT and MRS may improve the clinical response to TMZ, however, the use of OGAT inhibitors to potentiate the antitumor activity of TMZ might result in a concomitant increase of the immunosuppressive effects of the drug, thus reducing the relative TIFTI.
Tumor Immunology
5 Citations2002
Introduction, G. Parmiani and M. Lotze Immune recognition of Cancer-Tumor Antigens, P.O. Mortarini Humoral Recognition of Cancer, and Tumor Evasion of Immune System.
…