Fluoride toothpastes for preventing dental caries in children and adolescents
Cochrane Database of Systematic ReviewsPublished 20 January 2003Open access
Valéria CC Marinho, Julian P. T. Higgins, Stuart Logan, Aubrey Sheiham deceased
Citations839
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TL;DR
The effect of fluoride toothpastes increased with higher baseline levels of D(M)FS, higher fluoride concentration, higher frequency of use, and supervised brushing, but was not influenced by exposure to water fluoridation.
Abstract
Supported by more than half a century of research, the benefits of fluoride toothpastes are firmly established. Taken together, the trials are of relatively high quality, and provide clear evidence that fluoride toothpastes are efficacious in preventing caries.
Keywords
DentistryEnvironmental Science
BMJBias in meta-analysis detected by a simple, graphical test
56,268 Citations1997Matthias Egger, George Davey Smith +2 more
Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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983 Citations1999J.D.B. Featherstone
Low but slightly elevated levels of fluoride in saliva and plaque provided from these sources help prevent and reverse caries by inhibiting demineralization and enhancing remineralizations.
European Journal Of Oral SciencesReasons for the caries decline: what do the experts believe?
571 Citations1996D Bratthall, Gunnel Hänsel‐Petersson +1 more
There is a very large variation in how the experts graded the impact of various possible factors in the caries decline seen in many westernized countries over the past 3 decades.
Caries ResearchThe Prevalence of Dental Caries in Europe 1990-1995
414 Citations2009T.M. Marthaler, Janet A. Brunelle +8 more
Caries prevalence data from recent studies in all European countries showed a general trend towards a further decline for children and adolescents, however, in several countries with already low caries prevalence in primary teeth, there was no further decrease.
Journal of Dental ResearchThe Changing Patterns of Systemic Fluoride Intake
396 Citations1992Brian A. Burt
Two public health issues that arise are: (a) the need for a downward revision in the schedule for fluoride supplementation, and (b) education on the potential for high fluoride concentration of soft drinks and processed fruit juices.
Cochrane Database of Systematic ReviewsFluoride gels for preventing dental caries in children and adolescents
368 Citations2015Valéria CC Marinho, Helen V Worthington +2 more
The main outcome was caries increment measured by the change in decayed, missing and filled tooth surfaces in both permanent and primary teeth, with D(M)FS PF on average being 17% (95% CI 3% to 31%; P = 0.018) higher in non-placebo- trials than in other trials.
Community Dentistry And Oral EpidemiologyRelative contribution of dental services to the changes in caries levels of 12‐year‐old children in 18 industrialized countries in the 1970s and early 1980s
241 Citations1995Paulo Nadanovsky, Aubrey Sheiham
It is suggested that dental services were relatively unimportant in explaining the differences in changes in 12 year-old caries levels in the 1970s and early 1980s in the 18 countries.
Acta Odontologica ScandinavicaPrevention policies in the light of the changed distribution of dental caries
200 Citations1998Brian A. Burt
Medical Entomology and ZoologyFluorides in caries prevention
199 Citations1976John Murray
Fluoride and dental health in the 19th century addition of fluoride to school water supplies, salt, milk and fruit juice toxicity of fluoride, and the effects of fluoride on dental health are studied.
Journal of Public Health DentistryA Critique of Topical Fluoride Methods (Dentifrices, Mouthrinses, Operator‐, and Self‐applied Gels) in an Era of Decreased Caries and Increased Fluorosis Prevalence
177 Citations1991Louis W. Ripa
The reported caries decline reduces the number of surfaces prevented from developing caries, even though the percentage reduction remains substantially unchanged, and there is little evidence to suggest that dentifrice ingestion is a principal factor causing the fluorosis increase.
Cochrane Database of Systematic ReviewsFluoride gels for preventing dental caries in children and adolescents
148 Citations2002Valéria CC Marinho, Julian P. T. Higgins +2 more
Community Dentistry And Oral EpidemiologyFluoride varnishes (Duraphat): A meta‐analysis
146 Citations1994Ulrich Helfenstein, Marcel Steiner
A series of studies designed to detect the caries preventive effect of Duraphat by means of meta-analysis found it to be very unlikely that underreporting of non-significant results could reverse the conclusion into an overall null-result.
Caries ResearchA Meta-Analysis of Clinical Studies on the Caries-Inhibiting Effect of Fluoride Gel treatment
141 Citations1998H.M. van Rijkom, G.J. Truin +1 more
The ‘number needed to treat’ (NNT), indicating the number of patients that need to be treated in order to prevent 1 DMFS, estimated the efficiency of fluoride gel treatment according to the caries incidence of the target population, including cost/effect relations.
Journal of Periodontal ResearchThe effect of supervised oral hygiene on the gingivae of children
140 Citations1967Jan Lindhe, G Koch
The effect of prolonged supervision of tooth brushing on gingival health and oral hygiene in a group of school children 12–13 years of age was investigated and showed that, in spite of the great difference in GI found already at the first examination, theGingival condition in the experimental group had improved compared with that in the control group during the test year.
Acta Odontologica ScandinavicaTwo-Year Clinical Tests with Different Methods of Local Caries-Preventive Fluorine Application in Swedish School-Children
136 Citations1965P Torell, Yngve Ericsson
Community Dentistry And Oral EpidemiologyThe influence of toothbrushing frequency and post‐brushing rinsing on caries experience in a caries clinical trial
132 Citations1998Ivor G. Chestnutt, Fred Schäfer +2 more
Stated toothbrushing frequency and rinsing method after brushing were found to be strongly correlated with caries experience and caries increment and should be reflected in the design of oral health education material and taken into account in theDesign and analysis of caries clinical trials.
Caries ResearchEffect of Oral Care Habits on Caries in Adolescents
122 Citations2009R.K. Chesters, E. Huntington +2 more
A dose response to the three fluoride levels, i.e 1,000, 1,500, and 2,500 ppm F, was seen for the different habit combinations which could not be explained by differences in the baseline caries prevalence.
Community Dentistry And Oral EpidemiologyReview of fluoride exposures and ingestion
118 Citations1994Steven M. Levy
The literature on fluoride intake/ingestion was reviewed critically to determine the current exposure to fluorides for children living in non-fluoridated and fluoridated areas in North America and demonstrated that a substantial proportion of individuals had exposure or ingestion well beyond that of the mean for each source.
PubMedClinical effect and mechanism of cariostatic action of fluoride-containing toothpastes: a review.
115 Citations1991Gunnar Rölla, B. Øgaard +1 more
Caries reduction has been observed in certain parts of the western world and it is possible that improved oral hygiene and use of fluoride have a synergistic effect.
Journal of Dental ResearchAcute and Chronic Fluoride Toxicity
112 Citations1992Gary M. Whitford
There is no evidence for risk in the US up to the level of intake that is associated with drinking water containing 4 ppm, and two new reports, however, have implicated chronic fluoride intake at relatively low levels in a higher incidence of bone fractures.
Community Dentistry And Oral EpidemiologyA 3‐year oral health dose‐response study of sodium monofluoro‐phosphate dentifrices with and without zinc citrate: anti‐caries results
105 Citations1988Kenneth W. Stephen, S.L. Creanor +4 more
A significant anti-caries dose-response was demonstrated over the SMFP range used and was evident for boys and girls and also for the various types of teeth and tooth surfaces.
Community Dentistry And Oral EpidemiologyThe effect of various plaque control measures on gingivitis and caries in schoolchildren
95 Citations1976Per Axelsson, Jan Lindhe +1 more
Results showed that by oral hygiene instruction and frequently repeated professional tooth cleanings it was possible to substantially reduce the frequency of gingivitis and prevent caries, and revealed that interdental cleaning with mechanical instruments was of decisive importance in the prevention of approximal surface caries.
Community Dentistry And Oral EpidemiologyFluoride intake from foods, beverages and dentifrice by young children in communities with negligibly and optimally fluoridated water: a pilot study
91 Citations1999Rojas-Sanchez Fatima, Sue Kelly +4 more
Attention needs to be given, in negligibly water-fluoridated as well as in optimally water- fluoridated communities, to reducing the daily intake of fluoride by young children in order to avoid putting them at risk of developing dental fluorosis.
Journal of Dental ResearchA Three-year Clinical Trial of a Combination of Trimetaphosphate and Sodium Fluoride in Silica Toothpastes
86 Citations1997D O'Mullane, Donncha Kavanagh +5 more
Results showed that subjects who claimed to brush more frequently or who claimed not to use a tumbler to rinse after toothbrushing had lower three-year DFMS increments, and there was no significant difference between the mean DMFS increment for those using paste with or without TMP.
Caries ResearchA Simultaneous Reduction of Caries and Gingivitis in a Group of Schoolchildren Receiving Chlorhexidine-Fluoride Applications
85 Citations2009H. Luoma, Heikki Murtomaa +5 more
After 2 years, the mean DMFS increments in the C, Pl, F and CXF groups were 6.3, 5.3 and 2.9, respectively, and the percentage of subjects with bleedingibular gingival units examined in different groups had changed from initial to final value.
BDJFluoride ingestion from toothpaste by young children
79 Citations1999Elaine Bentley, R.P. Ellwood +1 more
It is essential that parents of children aged less than 7 years apply a small (pea-sized) amount of fluoride toothpaste on the toothbrush and discourage swallowing.
Journal of Public Health DentistryThe Need for Toothpastes with Lower than Conventional Fluoride Concentrations for Preschool‐aged Children
71 Citations1992Herschel S. Horowitz
Considering today's reduced risk of caries, it is timely to market fluoride toothpastes in the US with 400-500 ppm fluoride for preschool-aged children, who are still at risk for developing fluorosis, as has been done in several other countries.
Caries ResearchComparative Efficacy of NaF and SMFP Dentifrices in Caries Prevention: A Meta-Analytic Overview
57 Citations2009Mary F. Johnson
Based on a pool of studies involving over 7,000 subjects, NaF was associated with a significantly greater reduction in caries development compared to SMFP, and analysis of data from dual-active studies indicated that NaF in combination with SMFP provides greater lowering of the D(M)FS increment, whereas the dual- active product demonstrated no advantage over NaF alone.
European Journal Of Oral SciencesCaries increment and gingival status during 2 years' use of chlorhexidine‐ and fluoride‐containing dentifrices
57 Citations1980OVE K. DOLLES, Per Gjermo
There was less caries in the group using the dentifrice containing fluoride and chlorhexidine than in the two other test groups, and the differences in caries increment between the groups were not statistically significant.
The Journal of the American Dental AssociationClinical Evaluation of Three Concentrations of Sodium Fluoride in Dentifrices
55 Citations1973Marvin W. Reed
DMFT and DMFS increments after one and two years show that all three levels of sodium fluoride reduce caries Incidence.
The Journal of the American Dental AssociationA comparison between the anticariogenic effects of dentifrices containing stannous fluoride and sodium fluoride
54 Citations1955Joseph C. Muhler, Arthur W. Radike +2 more
The results after one year corroborate the superiority o f stannous fluoride as an anticariogenic agent and indicate the effect o f each o f these fluorides when placed in identi cal dentifrices.
Caries ResearchToothbrushing Habits and Caries Experience
51 Citations1999Paul Ashley, David C. Attrill +3 more
The aim of this study was to confirm the association between reported toothbrushing and rinsing behaviour and caries experience in adolescents from Manchester, UK.
PubMedCaries prevalence in Switzerland.
43 Citations1994Marthaler Tm, M Steiner +2 more
The first Swiss studies of DMFT counts were undertaken in the late 1950s and showed values of 7.7-11.3 for children of 12 years of age and 12.6-18.6 for adults, while the most recent surveys present a startling contrast.
Caries ResearchA Four-Year Clinical Study to Determine the Caries-Inhibiting Effect of Calcium Glycerophosphate and Sodium Fluoride in Calcium Carbonate Base Dentifrices Containing Sodium Monofluorophosphate
41 Citations2009Peter J. Mainwaring, M.N. Naylor
A double-blind, clinical trial involving 923 children and extending over 4 years was carried out on the Isle of Wight and investigated the additional protection against dental caries resulting when an MMR vaccine is given.
Community Dentistry And Oral EpidemiologyReview of fluorosis risk of self‐applied topical fluorides: dentifrices, mouthrinses and gels
40 Citations1994George K. Stookey
Although there is little direct evidence to suggest that the use of self-applied fluoride gels contributes to the development of dental fluorosis, ingestion of fluoride from these systems is of genuine concern and their use by preschool age children is not recommended.
PubMedReversal of incipient and radiographic caries through the use of sodium and stannous fluoride dentifrices in a clinical trial.
40 Citations1998Aaron R Biesbrock, Robert V. Faller +3 more
Journal of Periodontal ResearchThe effect of supervised oral hygiene on the gingiva of children. The effect of sodium fluoride
39 Citations1967G Koch, Jan Lindhe
The investigation revealed that sodium fluoride applied by means of a dentifrice slurry did not affect the gingiva, and sodium fluoride in the concentration of 0.5 % in a mouth rinse proved detrimental to theGingiva.
The Journal of the American Dental AssociationComparative study of a fluoride dentifrice containing soluble phosphate and a calcium-free abrasive: second-year report
39 Citations1966F. Brudevold, Neal W. Chilton
Effects of five different dentifrice formulations after 2 years of use in an unsupervised, permissive toothbrushing study are reported.
Community Dentistry And Oral EpidemiologyClinical trial among Scottish children of an anti‐caries dentifrice containing 2% sodium monofluorophosphate
38 Citations1973J.A. Hargreaves, G. G. Chester
Journal of Public Health DentistryReview of the Anticaries Effectiveness of Professionally Applied and Self ‐applied Topical Fluoride Gels
37 Citations1989Louis W. Ripa
Current epidemiological evidence does not indicate a need for public health caries preventive programs for healthy employed adults, and a variety of topical gel procedures appear to be effective in limiting caries.
Community Dentistry And Oral EpidemiologyComparative unsupervised clinical trial on caries inhibition effect of monofluorophosphate and amine fluoride dentifrices after 3 years in Strasbourg, France
36 Citations1982P.M. Cahen, R.M. Frank +2 more
A randomized, double blind clinical trial of the caries inhibition effects of dentifrices containing respectively monofluorophosphate and amine fluoride was performed on schoolchildren ranging in age from 6 to 8 years and living in Strasbourg (France).
Community Dentistry And Oral EpidemiologyCombined effects of a fluoride dentifrice and mouthrinse on the incidence of dental caries
35 Citations1983Anthony S. Blinkhorn, P J Holloway +1 more
Both the dentifrice and mouthrinse reduced the incidence of dental caries, but their combined use at the same time had no greater effect than either used alone.
Caries ResearchDental Enamel Opacities in Three Groups with Varying Levels of Fluoride in Their Drinking Water
32 Citations2009R.P. Ellwood, D O'Mullane
The number of teeth affected by these enamel defects and their severity did not follow the dose-response relationship expected from the fluoride levels in the drinking water.
Caries ResearchA Three-Year Clinical Study to Determine the Separate and Combined Caries-Inhibiting Effects of Sodium Monofluorophosphate Toothpaste and an Acidulated Phosphate-Fluoride Gel
32 Citations2009Peter J. Mainwaring, M.N. Naylor
This report describes a clinical study carried out to compare the cariesinhibiting effect of the unsupervised home use of a sodium-monofluorophosphate-calcium-carbonate-based toothpaste formulation.
PubMedA three-year clinical caries evaluation of the effect of a sodium fluoride-silica abrasive dentifrice.
31 Citations1981Zacherl Wa
After three years of ad libitum product usage, the results showed that the group using the sodium fluoride dentifrice had significantly fewer DMF teeth and DMF surfaces increments than the group use the stannous fluoride dent ifrice.
The Journal of the American Dental AssociationThe caries-preventive effect of amine fluorides and inorganic fluorides in a mouthrinse or dentifrice after 30 months of use
30 Citations1979Melvin L. Ringelberg, David B. Webster +2 more
There was no significant difference in effectiveness against caries between the use of the organic or inorganic fluoride products.
PubMedIntroduction and rationale for the use of fluoride for caries prevention.
30 Citations1994O'Mullane Dm
It is now possible to adopt a more rational approach to the use of fluorides for caries prevention at community level and for individual patients.
Caries ResearchA 3-Year Clinical Trial of Calcium Carbonate Dentifrice Containing Calcium Glycerophosphate and Sodium Monofluorophosphate
30 Citations2009M.N. Naylor, Robert L. Glass
A double-blind clinical study extending over 3 years is reported to evaluate the efficacy of a calcium carbonate-based sodium monofluorophosphate den to treat central giant cell granuloma.
The Journal of the American Dental AssociationEvaluation of a stannous fluoride dentifrice for use in dental public health programs I. Basic findings
29 Citations1966Herschel S. Horowitz, Frank E. Law +2 more
Children who brushed in school as well as at home with the stannous fluoride dentifrice derived no additional benefits for caries control compared with benefits gained by children who brushed their teeth only at homewith the same dentif rice.
Caries ResearchAn Empirically Based System to Estimate the Effectiveness of Caries-Preventive Agents
29 Citations2009Christopher M. Clark, James A. Hanley +2 more
An empirically based system to estimate the effectiveness of caries-preventive agents could be useful to public health administrators in determining the cost-effectiveness estimates for various preventive programs.
Community Dentistry And Oral EpidemiologyStudies on the effect of dentifrices with low fluoride content
28 Citations1974B Forsman
A hypothetic model for the mode of action of MFP and NaF dentifrices is proposed with a view to continued development towards optimal clinical results with minimal F absorption.
PubMedThe decline of caries in New Zealand over the past 40 years.
27 Citations1998B. De Liefde
An explanation of the convergance of caries prevalence in fluoridated and non-fluoridated areas since the 1970s may require a re-assessment of the fluoride effect.
Community Dentistry And Oral EpidemiologyA 3‐year clinical trial of the effect on dental caries of a dentifrice containing 2% sodium monofluorophosphate
26 Citations1977P. M. C. James, R J Anderson +2 more
A clinical trial of a dentifrice containing 2% sodium monofluorophosphate was carried out on 782 schoolchildren in Shropshire, England, and those with a "medium" caries experience were found to benefit most from using the dentif rice.
PubMedEffect of supervised use of an alum mouthrinse on dental caries incidence in caries-susceptible children: a pilot study.
26 Citations1997C J Kleber, Mark S. Putt +2 more
It is demonstrated that daily supervised use of an alum mouthrinse inhibited caries development in decay-prone children at least as effectively as a F dentifrice.
European Journal Of Oral SciencesTooth stain during 2 years' use of chlorhexidine‐ and fluoride‐containing
26 Citations1979OVE K. DOLLES, Harald M. Eriksen +1 more
The results after 1 year showed that chlorhexidine induced less stain when applied together with fluoride than when applied alone, and after 2 years this difference disappeared, indicating that fluoride only retarded chlor hexidine-induced staining of teeth.
Community Dentistry And Oral EpidemiologyCaries‐preventive effect of a dentifrice containing 2% sodium monofluorophosphate in a natural fluoride area in Denmark
25 Citations1974O Lind, I.J. Møller +2 more
A comparison of the monofluorophosphate dentif rice with a null control dentifrice indicated that its use at home, coupled with regular motivation by home visitors, conferred about a 30 % reduction in dental caries increment over a 3-year period, beyond those anticariogenic benefits assumed to have been provided by the waterborne fluoride.
The Journal of the American Dental AssociationEffect on dental caries in children in a natural fluoride area of: Combined use of three agents containing stannous fluoride: a prophylactic paste, a solution and a dentifrice
23 Citations1965Charles W. Gish, Joseph C. Muhler
PubMedThe effect of a fluoride dentifrice containing an anticalculus agent on dental caries in children.
22 Citations1986Lu Kh, Yen Dj +4 more
In this double-blind caries study, 1160 Taiwanese children completed a program using a test dentifrice containing 1.243 percent sodium fluoride and soluble pyrophosphates, or a control dentif rice without these agents, which resulted in an average reduction of new carious tooth surfaces.
Community Dentistry And Oral EpidemiologyA 3‐year clinical trial into the effect of fluoride content and toothpaste abrasivity on the caries inhibitory properties of a dentifrice
21 Citations1980John Murray, Linda Shaw
Reducing the abrasivity of the toothpaste had no meaningful effect on the standard of oral hygiene and prevalence of gingivitis as measured by the Gingival and Plaque Indices.
Archives of Oral BiologySome statistical aspects of a clinical study on dental caries in children
20 Citations1968K. M. Cellier, Elizabeth A. Fanning +2 more
A significant reduction in caries increment was obtained from dentifrices containing 0.4 per cent stannous fluoride and 0.76 per cent sodium monofluorophosphate compared to a placebo, and analysis showed that partial recording of subjects may be utilized in such trials.
Community Dentistry And Oral EpidemiologyEffect on caries and gingivitis of a preventive program based on oral hygiene measures and fluoride application
19 Citations1982Ingegerd Zickert, Ann‐Marie Lindvau +1 more
The addition of fluoride (NaF or MFP) in mouthrinses and toothpastes significantly reduced the number of new carious lesions and professional tooth cleaning in combination with detailed oral hygiene instructions significantly improved their oral hygiene status and reduced clinical signs of gingivitis.
Caries ResearchThe Effects of Changing Caries Prevalence and Diagnostic Criteria on Clinical Caries Trials
19 Citations2009Robert L. Glass, John K. Peterson +1 more
In an area of water fluoridation (1 ppm), a clinical trial has been carried out with two examiners using two commercially available dentifrices containing 0.76% sodium monofluorophosphate (NaMFP).
The Journal of the American Dental AssociationEffect on dental caries in children in a nonfluoride area of combined use of three agents containing stannous fluoride: a prophylactic paste, a solution, and a dentifrice II. Results at the end of 24 and 36 months
18 Citations1966David Bixler, Joseph C. Muhler
Three technics—adding stannous fluoride to a prophylactic paste, using an aqueous solution after proPHylaxis, and using a stannOUS fluoride dentifrice at home—are better than 1 or 2 in combination for greatest reduction of caries.
Journal of Dental ResearchEffect of Stannous Fluoride Treatments on the Progression of Initial Lesions in Approximal Surfaces of Permanent Posterior Teeth
18 Citations1981Keith R. Powell, P. D. Barnard +1 more
Home use of a SnF 2 dentifrice in combination with the professional application of a 10% SnF2 solution markedly retarded the growth of initial lesions over a four-year period.
Royal Society of Medicine eBooksRelative efficacy of sodium fluoride and sodium monofluorophosphate as anti-caries agents in dentifrices
18 Citations1995William H. Bowen
Contribution of fluoride toothpastes to oral health, D. O'Mullane effect of fluorides on bacterial metabolism, and relative efficacy of sodium fluoride and monofluorosphosphate as anti-caries agents in dentifrices - clinical applications.
PubMedFluoride: how to maximize the benefits and minimize the risks.
17 Citations1998R.P. Ellwood, A S Blinkhorn +1 more
Current thinking on the rational use of fluoride for the safe and effective prevention of dental caries is reviewed so that benefits may be maximized and risks minimized.
Caries ResearchA Clinical Trial of a Calcium Carbonate Base Dentifrice Containing 0.76% Sodium Monofluorophosphate
17 Citations2009Robert L. Glass, F.R. Shiere
A clinical trial has been carried out with 0.76% sodium monofluorophosphate in a calcium carbonate base dentifrice and the regular use of the MFP dentif rice resulted in significantly lower caries.
PubMedComparison of recommended and actual mean intakes of fluoride by Canadians.
17 Citations1996Lewis Dw, Hardy Limeback
Exposure to fluoride should be closely monitored and inappropriate use of discretionary fluorides curtailed, especially in children seven months to four years of age, the age group most susceptible to fluorosis in the anterior permanent teeth.
American Journal of Public Health and the Nations HealthCARIES SYMPOSIUM, ZURICH
17 Citations1962Arthur Bushel
Community Dentistry And Oral EpidemiologyCaries prevention using a 1.2% sodium monofluorophosphate dentifrice in an aluminium oxide trihydrate base
17 Citations1984L Hanachowicz
The trial demonstrated a highly significant effectiveness of the 1.2% SMFP toothpaste in a French population just after fluoride toothpaste was allowed to be sold on the mass market.
Journal of Periodontal ResearchThe effect of a sodium monofluorophosphate dentifrice on the gingiva
16 Citations1969Inger Bay, I.J. Møller
It is suggested that using a dentifrice containing sodium monofluorophosphate - up to three times a day - for 30 months does not increase the incidence of plaque or gingivitis in children.
Community Dentistry And Oral EpidemiologyAnti‐caries effect of a 2% Na<sub>2</sub>PO<sub>3</sub>F‐dentifrice in a Danish fluoride area
16 Citations1976O Lind, F.R. von der Fehr +2 more
The evaluation showed that the test dentifrice had a valuable anti-caries effect in both age groups, above and beyond the effect of the waterborne fluoride.
Journal of Oral RehabilitationEffectiveness of fortnightly tooth brushing with amine fluorides in caries‐prone subjects
15 Citations1991Fanny Ran, I. Gedalia +3 more
The highest fluoride concentration in the gel reduced the development of caries to zero, probably due to increased fluoride levels in the oral milieu ofcaries risk children.
Caries ResearchA Comparison of Increment and Incidence Density Analyses in Evaluating the Anticaries Effects of Two Dentifrices
13 Citations1998Daniel J. Caplan, Gary D. Slade +4 more
Despite theoretical advantages, the ID method did not alter the conclusions drawn using DMFS increments, apparently because subjects lost to follow–up were similar to those completing the study, and loss to follow-up was similar among treatment groups.
The Journal of the American Dental AssociationEffectiveness of a SnF2-Ca2P2O7 dentifrice on dental caries in children whose teeth calcified in a natural fluoride area II. Results at the end of 24 months
13 Citations1966Charles W. Gish, Joseph C. Muhler
Results of this study at the end of 24 months are further evidence that use of a stannous fluoride dentifrice adds to the cariesreducing effect of fluoride in the water supply.
The Journal of the American Dental AssociationCombined use of three agents containing stannous fluoride: a prophylactic paste, a solution and a dentifrice
13 Citations1964David Bixler, Joseph C. Muhler
Children given all three stannous fluoride treatments had the highest reduction in dental caries after 6 and 12 months.
The Journal of the American Dental AssociationThe relative caries-inhibiting effects of a stannous fluoride dentifrice in a silica gel base
13 Citations1979Helmi R. Fogels, John E. Alman +2 more
An unsupervised toothbrushing study involving 1,339 children from 5 to 13 years of age conducted for three years compared two stannous fluoride dentifrices, one in a calcium pyrophosphate base and the other in a silica gel base, with a nonfluoride control dentifrice.
Caries ResearchA Supervised Brushing Trial of Sodium Monofluorophosphate Dentifrices in a Fluoridated Area
13 Citations2009John K. Peterson
An additional benefit was observed for the calcium carbonate based dentifrice over and above that assumed to have been due to water-borne fluoride, and was significantly greater than the other two dentifrices.
PubMedA clinical evaluation of a sodium fluoride dentifrice.
13 Citations1975Marvin W. Reed, Joseph King
A double-blind study to determine the anticaries efficacy of a neutral pH dentifrice containing sodium fluoride and a high Beta-phase calcium pyrophosphate was conducted among elementary school children in Kansas City, Missouri.
The Journal of the American Dental AssociationExperimental clinical human caries test design and interpretation
13 Citations1962David Bixler, Joseph C. Muhler
T o evaluate the effect o f m ultip le ex aminers on caries prevalence measure m ents, tw o exam iners participated in a clinical den ta l caries test study, in wich children fro m two similar schools used either a control dentifrice or a stannous fluoride dentif Rice.
Caries ResearchLong-Term Study of Effect of Supervised Toothbrushing with a Sodium Fluoride Dentifrice
12 Citations2009G Koch
The prolonged prophylactic effect of three years’ daily supervised toothbrushing with a 0.22% sodium fluoride effect dentifrice was studied in 113 schoolchildren.
Community Dentistry And Oral EpidemiologyCaries inhibition of a dentifrice containing 0.78% sodium monofluorophosphate in a silica base
11 Citations1984James T. Rule, Martyn R. Smith +3 more
Journal of PeriodontologyEffects of an Amine Fluoride Mouthrinse and Dentifrice on the Gingival Health and the Extent of Plaque of School Children
11 Citations1977Melvin L. Ringelberg, David B. Webster
There was no recognizable difference between the plaque and gingival reductions achieved with the use of the amine fluoride dentifrice or mouthrinse when compared either with their inorganic counterparts or with placebo treatment vehicles.
Journal of Dental ResearchInfluence of an Experimental Sodium Fluoride Dentifrice on Dental Caries Incidence in Children
10 Citations1975George K. Stookey, B B Beiswanger
Schoolchildren residing in a fluoride-deficient area were provided either a sodium fluoride (0.1% F) or a non fluoride dentifrice for home use and this resulted in dental caries reductions of 24 and 26% as noted by the two examiners.
JOURNAL OF DENTAL HEALTHA STUDY ON CARIES PREVENTION EFFECTS OF DENTIFRICES CONTAINING SODIUM MONOFLUOROPHOSPHATE, SODIUM MONOFLUOROPHOSPHATE PLUS DEXTRANASE, AND SODIUM MONOFLUOROPHOSPHATE PLUS SODIUM PHOSPHATE
9 Citations1975Teruo Niwa, Kyue Baba +1 more
It was confirmed that a continuous use of these four dentifrices over the period of one year did not result in oral anomalies either subjectively nor objectively.
The Journal of the American Dental AssociationEvaluation of a stannous fluoride dentifrice for use in dental public health programs III. Supplementary findings
9 Citations1967Herschel S. Horowitz, Mary B. Thompson
Archives of Oral BiologyThe effects of fluoride dentifrices on the incidence and distribution of stained tooth surfaces in children
9 Citations1968Elizabeth A. Fanning, T. Gotjamanos +3 more
The Journal of the American Dental AssociationA Multiple-Examiner Clinical Evaluation of a Sodium Fluoride Dentifrice
8 Citations1972Paul R. Weisenstein, W A Zacherl
Either a nontherapeutic dentifrice or a dentif rice containing sodium fluoride was assigned randomly to about 700 suburban schoolchildren for use, and statistically significant reductions of caries were found in children using the fluoride dentif Rice.
The Journal of the American Dental AssociationEffectiveness of a stannous fluoride-containing dentifrice in reducing dental caries in children in a boarding school environment
8 Citations1966David Bixler, Joseph C. Muhler
DMFS dental caries reductions of from 42 to 67 per cent were found, after 19 months, in subjects who used the stannous fluoride-calciuin pyrophosphate dentifrice.
The Journal of the American Dental AssociationEffectiveness of SnF2-Ca2P2O7 Dentifrice on Dental Caries in Children Whose Teeth Calcified in a Natural Fluoride Area I. Results at the End of 12 Months
8 Citations1965Charles W. Gish, Joseph C. Muhler +1 more
Journal of Dental ResearchClinical Science
7 Citations1980J. Ennever, John K. Peterson +3 more
Two similar sodium fluoride dentifrices, one neutral and one alkaline, were compared to a placebo for clinical effectiveness in reducing caries and both were significantly effective but were not different from each other.
JOURNAL OF DENTAL HEALTHA FIELD STUDY ON EFFECT OF A DENTIFRICE CONTAINING SODIUM MONOFLUOROPHOSPHATE IN CARIES PREVENTION
7 Citations1968Mitsuharu Takeuchi, Tokio Shimizu +2 more
From the results of field work, the dentifrice containing sodium monofluorophosphate was recognized to be effective in the prevention of dental caries.
The Journal of the American Dental AssociationEffect of SnF2 dentrifices on caries in children: Two-year clinical study of supervised brushing in children’s homes
7 Citations1966Adeeb E. Thomas, Homer C. Jamison
JOURNAL OF DENTAL HEALTHClinical trial on the reduction of caries incidence by use of two different fluoride dentifrices
6 Citations1970Masao Onisi, Hiroshi TANI
It was stressed in the present paper that use of actual susceptible site increased the rate of yearly cavitation of each groups, applying χ2-test on the results was absolutely necessary, and fluoride was effective for the caries appearing not only on the smooth surface but also on the pit and fissure.
PubMed[Clinical-radiological parallel control of a longitudinal study of the anti-caries effect of aminofluoride applied locally for 7 years in a double-blind test].
5 Citations1977W Künzel, W.‐G. Franke +1 more
In a comparison made for a period of more than seven years the anticarious effects of amine fluorides administered to selected groups of test subjects have been studied under controlled clinical experimental conditions.
The Journal of the American Dental AssociationEvaluation of a Stannous Fluoride Dentifrice for Use in Dental Health Programs. II. Operational Procedures
5 Citations1966Herschel S. Horowitz, Shirley R. Chamberlin
The methodology for developing a program of school toothbrushing and for handling and distributing supplies as used by the U.S. Public Health Service in their 3-year toothbrushes-dentifrice study is presented.
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