Cortical Metabolic Activation in Humans during a Visual Memory Task
Cerebral CortexPublished 1 May 1995
Barbara E. Swartz, Eric Halgren, Joaquı́n M. Fuster, Fiona Simpkins, M. Gee, M. Mandelkern
Citations93
SJR quartileQ1
SJR score1.45
SNIP1.03
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TL;DR
The role of the dorsal prefrontal region in the nonspatial working memory of humans is supported, and activation in the ventral premotor cortex and supramarginal and angular gyri areas underwent the greatest activation.
Abstract
A delayed match-to-sample (DMS) task of abstract, visual memory was performed during the uptake period of 18F-fluorodeoxyglucose. The increase in glucose uptake of cortical and subcortical regions ("activation") during the DMS task was compared with that during a control, immediate match-to-sample task using positron emission tomography. Both discriminant analysis and paired t tests supported the observation that the dorsolateral prefrontal area underwent the greatest activation, while a factor analysis revealed the functional correlation matrices of the tasks. Activations in the ventral premotor cortex and supramarginal and angular gyri were highly correlated with the change in the dorsolateral prefrontal cortex. The basal forebrain/ventral pole region showed a smaller but independently significant change. The findings support the role of the dorsal prefrontal region in the nonspatial working memory of humans.
Keywords
Neuroscience
Journal of NeurophysiologyMnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
2,721 Citations1989Shintaro Funahashi, Charles J. Bruce +1 more
An oculomotor delayed-response task was used to examine the spatial memory functions of neurons in primate prefrontal cortex and found that inhibitory responses were usually strongest for, or centered about, cue directions roughly opposite those optimal for excitatory responses.
The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe
2,388 Citations1980Joaquı́n M. Fuster
NatureThe neural correlates of the verbal component of working memory
2,243 Citations1993Eraldo Paulesu, Chris Frith +1 more
Comparisons of distribution of cerebral blood flow in these conditions localized the phonological store to the left supramarginal gyrus whereas the subvocal rehearsal system was associated with Broca's area, the first demonstration of the normal anatomy of the components of the 'articulatory loop'.
Proceedings of the National Academy of SciencesFocal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
2,065 Citations1986Peter T. Fox, Marcus E. Raichle
Comprehensive physiologyCircuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
1,936 Citations1987Patricia S. Goldman‐Rakic
ScienceNonoxidative Glucose Consumption During Focal Physiologic Neural Activity
1,809 Citations1988Peter T. Fox, Marcus E. Raichle +2 more
Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.
Journal of Cerebral Blood Flow & MetabolismComparing Functional (PET) Images: The Assessment of Significant Change
1,637 Citations1991Karl Friston, Chris Frith +2 more
This report describes an approach that may partially resolve the uncertainty in assessing the significance of statistical parametric maps and models the SPM as a stationary stochastic process.
Psychological ReviewWhat one intelligence test measures: A theoretical account of the processing in the Raven Progressive Matrices Test.
1,633 Citations1990Patricia A. Carpenter, Marcel Adam Just +1 more
ScienceDissociation of Object and Spatial Processing Domains in Primate Prefrontal Cortex
1,430 Citations1993Fraser A.W. Wilson, S. P. Scalaidhe +1 more
These findings indicate that the prefrontal cortex contains separate processing mechanisms for remembering "what" and "where" an object is.
Journal of Cognitive NeurosciencePositron Emission Tomographic Studies of the Processing of Singe Words
1,307 Citations1989Steven E. Petersen, Peter T. Fox +3 more
PET images of blood flow change that were averaged across individuals were used to identify brain areas related to lexical (single-word) processing, and a small number of discrete areas were activated during several task conditions.
NeuropsychologiaDeficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
1,281 Citations1982Michael Petrides, Brenda Milner
Patients with unilateral frontal- or temporal-lobe excisions and 18 normal control subjects were tested on four self-ordered tasks requiring the organization of a sequence of pointing responses, finding patients with temporal-love lesions not extending posteriorly and those with more radical hippocampal excisions exhibited material-specific deficits that varied with the side of the lesion.
NatureSpatial working memory in humans as revealed by PET
1,202 Citations1993John Jonides, Edward E. Smith +4 more
P positron emission tomography studies of regional cerebral blood flow in normal humans that reveal activation in right-hemisphere prefrontal, occipital, parietal and premotor cortices accompanying spatial working memory processes begin to uncover the circuitry of a working memory system in humans.
Proceedings of the National Academy of SciencesDissociation of object and spatial visual processing pathways in human extrastriate cortex.
1,048 Citations1991James V. Haxby, C L Grady +7 more
The ventral and dorsal locations of the regions specialized for object recognition and spatial localization, respectively, suggest some homology between human and nonhuman primate extrastriate cortex, with displacement in human brain, possibly related to the evolution of phylogenetically newer cortical areas.
Journal of Cerebral Blood Flow & MetabolismThe Relationship between Global and Local Changes in PET Scans
864 Citations1990Karl Friston, Chris Frith +4 more
Proceedings of the National Academy of SciencesDissociation of human mid-dorsolateral from posterior dorsolateral frontal cortex in memory processing.
664 Citations1993Michael Petrides, Bessie Alivisatos +2 more
These findings provide direct evidence that, just as the monkey brain, the human lateral frontal cortex is functionally heterogeneous and that comparable anatomical areas underlie similar functions in the two species.
NeuropsychologiaA PET study of word finding
654 Citations1991Chris Frith, Karl Friston +2 more
It is suggested that the superior temporal regions are the site of stored word representations and that inhibitory modulation of these areas by the left prefrontal cortex is the basis of intrinsic word generation.
Journal of NeuroscienceFunctional anatomy of human procedural learning determined with regional cerebral blood flow and PET
608 Citations1992ST Grafton, J.C. Mazziotta +4 more
The results demonstrate that changes of regional cerebral activity associated with early learning of skilled movements occur in sites that are a subset of a more widely distributed network that is active during motor execution.
Experimental NeurologyLocalization of function within the dorsolateral prefrontal cortex of the rhesus monkey
586 Citations1970Patricia S. Goldman, H. Enger Rosvold
It is suggested that the cortex in the principal sulcus may be concerned with a form of spatial memory, whereas the arcuate cortex is concerned with some other, as yet unspecified function.
The Journal of Comparative NeurologyCytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey
551 Citations1992Robert J. Morecraft, Changiz Geula +1 more
The distribution of retrograde labeling showed that the majority of the cortical projections to orbitofrontal cortex arises from a restricted set of telencephalic sources, which include prefrontal cortex, lateral, and inferomedial temporal cortex, the temporal pole, cingulate gyrus, insula, entorhinal cortex, hippocampus, amygdala, and claustrum.
Brain ResearchRegional glucose metabolic changes after learning a complex visuospatial/motor task: a positron emission tomographic study
490 Citations1992Richard J. Haier, Benjamin V. Siegel +4 more
Regional cerebral glucose metabolic rate (GMR) quantified with positron emission tomography with 18-fluoro-2-deoxyglucose (FDG) was measured twice in 8 young men performing a complex visuospatial/motor task, before and after practice, to suggest that learning may result in decreased use of extraneous or inefficient brain areas.
PubMedRelationships among local functional activity, energy metabolism, and blood flow in the central nervous system.
480 Citations1981Louis Sokoloff
The results demonstrate that the level of functional activity in the structural and functional components of the central nervous system regulates the local rate of energy metabolism, and local blood flow is adjusted to the local metabolic demand.
Annals of Internal MedicineAn Atlas of the Human Brain for Computerized Tomography.
467 Citations1978Takayoshi Matsui
Proceedings of the National Academy of SciencesNeuroanatomical correlates of retrieval in episodic memory: auditory sentence recognition.
457 Citations1994Endel Tulving, Shitij Kapur +4 more
The prevalence of sulcal blood-flow changes may reflect extensive cortical gyrification; it may also indicate that memory-related processes rely on the densely packed neuropil of sulCal regions.
Journal of NeurophysiologyVisuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms
449 Citations1990Shintaro Funahashi, Charles J. Bruce +1 more
Visual responses and their relationship to delay-period activity were studied by recording single neuron activity from the prefrontal cortex of rhesus monkeys while they performed an oculomotor delayed-response (ODR) and a visual probe (VP) task.
Brain ResearchFurther observations on corticofrontal connections in the rhesus monkey
439 Citations1976Douglas A. Chavis, Deepak Ν. Pandya
The frontal lobe connections of the post-Rolandic sensory association areas are investigated and it was found that the caudalmost portion of area 7 has a distinct projection pattern, connecting with the dorsal prearcuate cortex--areas 8B and 46.
Experimental NeurologyCellular discharge in the dorsolateral prefrontal cortex of the monkey in cognitive tasks
356 Citations1982Joaquı́n M. Fuster, Richard H. Bauer +1 more
Single-unit activity was recorded in the prefrontal cortex of monkeys performing two visual short-term memory tasks: delayed matching-to-sample and delayed response, reflecting the participation of prefrontal neurons in the temporal structuring of behavior.
PubMedNoninvasive functional brain mapping by change-distribution analysis of averaged PET images of H215O tissue activity.
338 Citations1989Peter T. Fox, Mark A. Mintun
Most research and clinical applications of functional brain mapping can employ images of H215O tissue activity (intravenous bolus, 40-sec nondynamic scan) without conversion to units of blood flow, thereby simplifying and minimizing the invasivity of the PET procedure.
Journal of NeuroscienceCoactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey
318 Citations1994HR Friedman, P.S. Goldman-Rakic
These are the first results showing concurrent metabolic activation of the prefrontal and parietal cortex in monkeys performing working memory tasks and they support the suggestion that these cortical regions represent two important nodes in a neural network mediating spatial working memory in the monkey.
Journal of Comparative and Physiological PsychologyDelayed-matching and delayed-response deficit from cooling dorsolateral prefrontal cortex in monkeys.
281 Citations1976Richard H. Bauer, Joaquı́n M. Fuster
The FC-induced decrements in proportion of correct responses suggest a faster loss from short-term memory of both spatial and nonspatial information.
NeuroreportMnemonic and predictive functions of cortical neurons in a memory task
246 Citations1992Javier Quintana, Joaquı́n M. Fuster
These findings suggest that neurons from prefrontal and parietal cortex are part of distributed networks, with representational and operational properties, for visuo- motor cognitive processing.
Journal of Cerebral Blood Flow & MetabolismA Noninvasive Approach to Quantitative Functional Brain Mapping with H <sub>2</sub> <sup>15</sup> O and Positron Emission Tomography
241 Citations1984Peter T. Fox, Mark A. Mintun +2 more
This study demonstrates that quantitative functional brain mapping does not require the determination of r CBF from Cr when regional neuronal activation is expressed as the change in rCBF from an initial, resting-state measurement.
Journal of NeurophysiologySupplementary motor area: neuronal response to motor instructions
232 Citations1980J. Tanji, Kosuke Taniguchi +1 more
Observations substantiate the hypothesis that the supplementary motor area plays a part in modifying a sensory-triggered motor output as the monkeys gained more experience in responding to the triggering stimulus.
NeuropsychologiaFunctional anatomy of language processing: Neuroimaging and the problem of individual variability
225 Citations1991Helmuth Steinmetz, Rüdiger J. Seitz
It is argued that PET studies of higher cognitive functions including language must focus on individual anatomo-functional organization using techniques such as intrasubject averaging, as well as evidence which suggests that intersubject variability is at least two-fold.
Journal of Physiology-ParisSpatio-temporal stages in face and word processing. 2. Depth-recorded potentials in the human frontal and Rolandic cortices
216 Citations1994Eric Halgren, Patrick Baudena +4 more
Journal of NeuroscienceActivation of the hippocampus and dentate gyrus by working-memory: a 2- deoxyglucose study of behaving rhesus monkeys
212 Citations1988HR Friedman, P.S. Goldman-Rakic
The findings suggest that working-memory may be a common denominator among those tasks that are sensitive to hippocampal damage in monkeys, and the contribution of the amygdala to performance on memory tasks, on the other hand, appears to be independent of the specific type of memory process that is engaged.
Brain ResearchPrefrontal unit activity during delayed alternation in the monkey. I. Relation to direction of response
211 Citations1974Hiroaki Niki
Out of 502 units studied in both hemispheres, 198 showed a relation to aspects of the DA task, and half of these related units showed a differential firing pattern depending on the trial (left or right).
Brain ResearchPrefrontal representation of stimulus attributes during delay tasks. I. Unit activity in cross-temporal integration of sensory and sensory-motor information
210 Citations1988Javier Quintana, Javier Yajeya +1 more
The activity of 294 single units was recorded from the dorsolateral prefrontal cortex of monkeys performing two visual discrimination tasks with delayed response, suggesting the role of prefrontal neurons in the representation of multiple attributes of sensory stimuli, including their associated motor connotations, and the overlap of the cortical representations of different attributes.
Advances in psychologyNeural Circuits for Spatial Attention and Unilateral Neglect
171 Citations1987Giacomo Rizzolatti, Rosolino Camarda
This article reviews three theories that have been advanced to explain this neurological syndrome, discusses their limitations, and advances an alternative hypothesis based on a model of spatial attention.
Journal of Cerebral Blood Flow & MetabolismA Noninvasive Positron Computed Tomography Technique Using Oxygen-15-Labeled Water for the Evaluation of Neurobehavioral Task Batteries
166 Citations1985John C. Mazziotta, Sung‐Cheng Huang +4 more
Visual stimulation studies in normal volunteers demonstrated relative radioisotope concentration changes between control and stimulated states that are in good agreement with similar results obtained using the same stimulation paradigm but with the use of fluorodeoxyglucose to determine cerebral glucose metabolism.
Proceedings of the Royal Society B Biological SciencesMonitoring of selections of visual stimuli and the primate frontal cortex
148 Citations1991Michael Petrides
Findings delineate the mid-dorsolateral frontal cortex as a critical component of a neural system mediating the monitoring of self-generated responses in non-human primates as well as highlighting its importance in the recognition and recall of prior choices.
Journal of Cerebral Blood Flow & MetabolismReproducibility of Cerebral Glucose Metabolic Measurements in Resting Human Subjects
138 Citations1988Elsa J. Bartlett, Jonathan D. Brodie +4 more
This first study to measure test-retest variability in cerebral glucose metabolism in a large sample of young normal subjects demonstrates that the deoxyglucose method yields low Intrasubject variability and high stability over a 24-h period.
Progress in NeurobiologyThe neuropathology of amnesia
86 Citations1985Hans J. Markowitsch, Monika Pritzel
The value of investigating inter-dependencies between brain structures is emphasized by pointing out that relations between memory disturbances and brain damage may be more complicated than apparent from a simple structure-function assignment.
Journal of NeuropsychiatryCerebral metabolic dysfunction in AIDS: findings in a sample with and without dementia
86 Citations1992Wilfred G. van Gorp, M. Mandelkern +8 more
Results suggest that the basal ganglia, thalamus, and temporal lobes are differentially affected in HIV, with a significant relationship for the AIDS group between temporal lobe metabolism and severity of dementia on the AIDS Dementia Complex Rating Scale.
Cambridge University Press eBooksThe development of the concept of working memory: implications and contributions of neuropsychology
76 Citations1990Alan Baddeley
Elsevier eBooksDissociation of Object and Spatial Visual Processing Pathways in Human Extrastriate Cortex
72 Citations1993James V. Haxby, Cheryl L. Grady +5 more
The ventral and dorsal locations of the regions specialized for object recognition and spatial local-ization, respectively, suggest some homology between human and nonhuman primate extrastriate cortex, with displacement in human brain, possibly related to the evolution of phyloge- netically newer cortical areas.
Journal of Cognitive NeuroscienceEnhancement of Metabolic Activity in the Diencephalon of Monkeys Performing Working Memory Task: A 2-Deoxyglucose Study in Behaving Rhesus Monkeys
52 Citations1990Harriet R. Friedman, Janice D. Janas +1 more
The results show that working memory has a wide-ranging influence on cerebral metabolism and emphasize the cooperative, rather than dissociable, roles of the hippocampus and medial thalamus in this function.
Journal of EpilepsyPrimary memory in patients with frontal and primary generalized epilepsy
43 Citations1994Barbara E. Swartz, Eric Halgren +2 more
The frontal lobe group showed impairment on both tasks, particularly the primary memory task and the worst performance on all measures, and may be due to persistent postictal effects, interictal spikes, or spike wave complexes or to the underlying pathophysiology that is also responsible for the epileptic state.
Behavioural Brain ResearchLocalized brain metabolic response correlated with potentials evoked by words
42 Citations1991Valeriy I. Nevov, Eric Halgren +5 more
The temporal and psychological resolution of EPs is combined with the spatial resolution of PET to help define when and where in the brain words are encoded for meaning.
Critical issues in neuropsychologyPositron Emission Tomography and Neuropsychological Function
41 Citations1989G. Pawlik, Wolf‐Dieter Heiss
Recent interdisciplinary research has shown much evidence to the contrary of the old universalistic notion that localization is an artificial observer-made attribute of the brain, but at a more sophisticated conceptual level of stochastic cybernetics.
NeuroreportAn 18FDG-PET study of cortical activation during a short-term visual memory task in humans
36 Citations1994Barbara E. Swartz, Eric Halgren +2 more
The results complement previous studies in that they substantiate the role of the prefrontal cortex in the mediation of cross-temporal contingencies of behavior, and point to arole of the premotor region in this mediation as well.