CNS tryptamine metabolism in hepatic coma
Journal of Neural TransmissionPublished 1 September 1980
Simon N. Young, Samarthji Lal
Citations34
SJR quartileQ1
SJR score1.11
SNIP1.13
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TL;DR
There was a strong correlation between the grade of hepatic coma and CSF IAA, and data indicate that there is an association between elevated CNS tryptamine metabolism and liver dysfunction.
Abstract
Lumbar CSF indoleacetic acid (IAA) was higher in patients with cirrhosis of the liver than in controls. It was also higher in CSF of patients in coma than in those with hepatic cirrhosis but not in coma. There was a strong correlation (r = 0.89, p less than 0.01) between the grade of hepatic coma and CSF IAA. These data indicate that there is an association between elevated CNS tryptamine metabolism and hepatic coma. How far changes in the metabolism of tryptamine and other trace amines are relevant to the induction of hepatic coma or are simply a reflection of advanced liver dysfunction is unclear.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
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65 Citations1975Simon N. Young, Samarthji Lal +4 more
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The urinary excretion of N,N-dimethyltryptamine (DMT) was higher in patients with severe liver disease than in normal subjects, and this difference remained significant when patients with all grades of hepatic encephalopathy were excluded.
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