Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam
European Journal of PharmacologyPublished 1 December 1996
Ants Kask, Lembit Rägo, Jaanus Harro
Citations95
SJR quartileQ1
SJR score1.20
SNIP0.98
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TL;DR
The hypothesis that neuropeptide Y Y1 receptor subtype is involved in anxiety regulation is supported by the study of exploratory behaviour of rats in the elevated plus-maze.
Abstract
The effect of the novel non-peptide neuropeptide Y Y1 receptor antagonist BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)-methyl]-D-arginine amide, on exploratory behaviour of rats in the elevated plus-maze was studied. BIBP3226 (0.5 and 5 micrograms, i.c.v.) induced an anxiogenic-like effect at the higher dose tested. This effect was antagonised by diazepam (0.5 mg/kg). The anxiogenic-like effect of BIBP3226 was not related to a decrease in general locomotor activity. These findings support the hypothesis that neuropeptide Y Y1 receptor subtype is involved in anxiety regulation.
Keywords
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