A direct demonstration of functional specialization within motion-related visual and auditory cortex of the human brain
Current BiologyPublished 1 August 1996Open access
Robert Howard, M. Brammer, Ian C. Wright, Peter Woodruff, Edward T. Bullmore, Semir Zeki
Citations175
SJR quartileQ1
SJR score2.71
SNIP1.83
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The technique of functional magnetic resonance imaging was used, in order to image the same subjects repeatedly, and it was found that each of the three motion stimuli activated specific parts of the V5 complex.
Abstract
The three sites of activation produced by the visual motion stimuli occupy adjacent territories within the V5 complex. Components of the V5 complex are specifically connected to regions within auditory cortex.
Keywords
PsychologyNeuroscience
Choice Reviews OnlineNumerical recipes in C: the art of scientific computing
17,989 Citations1993Press, William H, Flannery, Brian P +2 more
Clinical Neurology and NeurosurgeryCo-planar stereotaxic atlas of the human brain
7,606 Citations1989Lauri A. Laitinen
Perception & PsychophysicsVisual perception of biological motion and a model for its analysis
4,444 Citations1973Gunnar Johansson
The kinetic-geometric model for visual vector analysis originally developed in the study of perception of motion combinations of the mechanical type was applied to biological motion patterns and the results turned out to be highly positive.
Magnetic Resonance in MedicineMovement‐Related effects in fMRI time‐series
3,935 Citations1996Karl Friston, Steven Williams +3 more
The empirical analyses suggest that (in extreme situations) over 90% of fMRI signal can be attributed to movement, and that this artifactual component can be successfully removed.
Journal of NeuroscienceA direct demonstration of functional specialization in human visual cortex
1,737 Citations1991Semir Zeki, J D Watson +4 more
PET is used to demonstrate directly the specialization of function in the normal human visual cortex, and provides direct evidence to show that, just as in the macaque monkey, different areas of the human prestriate visual cortex are specialized for different attributes of vision.
Journal of NeuroscienceFunctional analysis of human MT and related visual cortical areas using magnetic resonance imaging
1,444 Citations1995RB Tootell, J.B. Reppas +6 more
FMRI activity in human MT does in fact decrease at and near individually measured equiluminance, and area MT has a much higher contrast sensitivity than that in several other areas, including primary visual cortex (V1).
Cerebral CortexArea V5 of the Human Brain: Evidence from a Combined Study Using Positron Emission Tomography and Magnetic Resonance Imaging
1,246 Citations1993J D Watson, R. Myers +6 more
P positron emission tomography was used to determine the foci of relative cerebral blood flow increases produced when subjects viewed a moving checkerboard pattern, compared to viewing the same pattern when it was stationary.
ScienceDiscrete Cortical Regions Associated with Knowledge of Color and Knowledge of Action
1,082 Citations1995Alex Martin, James V. Haxby +3 more
The areas of the brain that mediate knowledge about objects were investigated by measuring changes in regional cerebral blood flow using positron emission tomography (PET), and data suggest that object knowledge is organized as a distributed system in which the attributes of an object are stored close to the regions of the cortex that mediated perception of those attributes.
The Journal of PhysiologyFunctional organization of a visual area in the posterior bank of the superior temporal sulcus of the rhesus monkey
989 Citations1974Semir Zeki
The Journal of Comparative NeurologyCortical connections of visual area MT in the macaque
973 Citations1986Leslie G. Ungerleider, Robert Desimone
The cortical connections of area MT were identified and their topographic organization and relationship to myeloarchitectural fields were determined and macaques that had received injections of tritiated amino acids and fluorescent dyes were examined.
Magnetic Resonance in MedicineStatistical methods of estimation and inference for functional MR image analysis
699 Citations1996Edward T. Bullmore, Michael Brammer +7 more
An approach to fit a time series regression model, including sine and cosine terms at the (fundamental) frequency of experimental stimulation, by pseudogeneralized least squares (PGLS) at each pixel of an image to create inferential brain activation maps (BAMs) of pixels significantly activated by the experimental stimulus.
NatureVisual motion aftereffect in human cortical area MT revealed by functional magnetic resonance imaging
670 Citations1995Roger B. H. Tootell, John B. Reppas +6 more
A clear increase in activity is demonstrated in human cortical area MT when subjects viewed a stationary stimulus undergoing illusory motion, following adaptation to stimuli moving in a single local direction.
Brain ResearchVisual areas in the temporal cortex of the macaque
558 Citations1979Robert Desimone, Charles G. Gross
Visual receptive fields and responsiveness of neurons to somesthetic and auditory stimuli were studied in the inferior temporal cortex and adjacent regions of immobilized macaques and showed no indication of any visuotopic organization within area TE.
Journal of Cognitive NeuroscienceResponses of Anterior Superior Temporal Polysensory (STPa) Neurons to “Biological Motion” Stimuli
387 Citations1994Mike W. Oram, David I. Perrett
The cell responses provide direct evidence for neural mechanisms computing form from nonrigid motion and the selectivity of the cells was for body view, specific direction, and specific type of body motion presented by moving light displays and is not predicted by many current computational approaches to the extraction of form from motion.
Visual NeuroscienceIntact “biological motion” and “structure from motion” perception in a patient with impaired motion mechanisms: A case study
235 Citations1990Lucia M. Vaina, Marjorie Lemay +3 more
The patient with bilateral lesions involving the posterior visual pathways, affecting the lateral parietal-temporal-occipital cortex and the underlying white matter was able to identify actions from the evolving pattern of dots placed at the joints of a human actor as well as discriminating three-dimensional structure of a cylinder from motion in a dynamic random-dot field.
Proceedings of the National Academy of SciencesFirst-order analysis of optical flow in monkey brain.
222 Citations1992Guy A. Orban, Lieven Lagae +5 more
The results show that MST cells, but not MT cells, are selective for elementary flow components (EFCs) alone or their combination with translation, and that position invariance as observed in MST is compatible with an input arrangement from MT cells matching the selectivity of MST neurons.
Proceedings of the Royal Society B Biological SciencesGoing beyond the information given: the relation of illusory visual motion to brain activity
220 Citations1993Semir Zeki, J D Watson +1 more
It is found that, when subjects perceived illusory motion, the increases in r CBF took place in regions of the brain closely related to, and perhaps identical with, area V5, as defined by the site of rCBF change that took place when the same subjects viewed a physically moving stimulus.
BrainThe physiology of coloured hearing A PET activation study of colour-word synaesthesia
213 Citations1995Eraldo Paulesu, John Harrison +6 more
The results suggest that colour-word synaesthesia may result from the activity of brain areas concerned with language and visual feature integration, as conscious visual experience appears to occur without activation of the primary visual cortex.
The Journal of PhysiologyCells responding to changing image size and disparity in the cortex of the rhesus monkey
181 Citations1974Semir Zeki
The cells of the cortex of the posterior bank of the superior temporal sulcus of the monkey appear to be specialized to signal motion in the visual field.
BrainThe cerebral activity related to the visual perception of forward motion in depth
176 Citations1994Bauke M. de Jong, Stewart Shipp +3 more
These results show that higher stages of motion take place in both the 'dorsal' and 'ventral' visual pathways, as these are commonly conceived, and that both may be fed by area V3.
BrainThe brain activity related to residual motion vision in a patient with bilateral lesions of V5
110 Citations1994Stewart Shipp, Bauke M. de Jong +3 more
It is hypothesized that the bilateral loss of V5 has affected direction sensitive mechanisms at other sites in the cortex which are interconnected with V5 and that in consequence her performance on tests reflects the properties of dynamic orientation selective mechanisms that were also differentially activated by the stimuli used during scanning.
PerceptionRecognition of Animal Locomotion from Dynamic Point-Light Displays
99 Citations1993George Mather, Sophie West
The ability to interpret biological motion is general and is not restricted to human movements.
Experimental Brain ResearchParietal cortical neurons responding to rotary movement of visual stimulus in space
98 Citations1986H Sakata, Hidetoshi Shibutani +2 more
A group of neurons that were specifically sensitive to the rotation of a visual stimulus were found in the posterior parietal association cortex of alert monkeys, and may be related directly to the perception of rotation of visual objects in space.
Cold Spring Harbor Symposia on Quantitative BiologyFunctional Specialization for Visual Motion Processing in Primate Cerebral Cortex
71 Citations1990Robert H. Wurtz, Dwayne S. Yamasaki +2 more
Annals of the New York Academy of SciencesNeuronal Correlates of Optic Flow Stimulation
56 Citations1992Robert H. Wurtz, Charles J. Duffy
Generation of behavior on the basis of the optic flow stimulation and determination that this behavior is modified by selective lesion of MSTd would also strengthen the argument that visual motion processing in this area is related to analyzing optic flow information.
NeuropsychologiaPerception of optical flow in cortical blindness: A case report
36 Citations1992Daniel Mestre, Michéle Brouchon +2 more
The results suggest that perimetrically "blind" parts of the visual field in this patient have true capacities to process visual motion.
