TFMPP may produce its stimulus effects via a 5-HT1B mechanism
Pharmacology Biochemistry and BehaviorPublished 1 January 1986
J.D. McKenney, Richard A. Glennon
Citations49
SJR quartileQ1
SJR score0.95
SNIP0.81
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is suggested that the stimulus properties of TFMPP are mediated primarily via a 5-HT1B mechanism.
Abstract
Tests of stimulus generalization were conducted using rats trained to discriminate 1.0 mg/kg of 1-(3-trifluoromethylphenyl)piperazine (TFMPP) from saline in a standard two-lever operant procedure. Generalization of the TFMPP-stimulus was found to occur with fenfluramine and 1-(3-chlorophenyl)-piperazine (mCPP); generalization did not occur with 8-OH DPAT, quipazine, LSD, 5-OMe DMT or 2,5-DMA. Furthermore, the TFMPP-stimulus was not antagonized by pretreatment of the animals with tetrahydrotrazodone (THT). Based on the results of these studies, and on the results of previous binding studies with these same agents, it is suggested that the stimulus properties of TFMPP are mediated primarily via a 5-HT1B mechanism.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
Molecular PharmacologyMultiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
1,354 Citations1979Stephen J. Peroutka, Solomon H. Snyder
It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
European Journal of Pharmacology8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site
869 Citations1983Derek N. Middlemiss, John R. Fozard
Life SciencesEvidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents
636 Citations1984Richard A. Glennon, Milt Titeler +1 more
The results of this study suggest that the mechanism of action of these agents involves 5-HT2-related events.
Journal of Pharmacology and Experimental TherapeuticsDetermination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.
330 Citations1984Matthew A. Sills, Barry B. Wolfe +1 more
The ability of a series of drugs to compete for 15 nM [3H]-5-HT binding in the presence of 1 mM GTP in the rat frontal cortex was examined to examine the ability of these drugs to selectivity for two subtypes of the 5-HT1 receptor.
Journal of Pharmacology and Experimental TherapeuticsDifferential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat.
303 Citations1984Irwin Lucki, Mitchell S. Nobler +1 more
Compared the actions of ketanserin and pipamperone and metergoline and methysergide on two behavioral responses in rats that are produced by the activation of 5-HT receptors, the order of relative potency for these drugs to block the head shake response was the same as their reported affinity for the 5- HT2 receptor, which suggests that the5-HT2 receptor is involved in the headshake response.
Naunyn-Schmiedeberg s Archives of PharmacologyComparison of the pharmacological characteristics of 5 HT1 and 5 HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release
200 Citations1982Louis L. Martin, Elaine Sanders‐Bush
Results demonstrate that the 5HT autoreceptor and the 5 HT1 binding site have similar pharmacological characteristics and it is suggested that 5 HT autoreceptors and the5 HT1binding site may be related 5 HT receptor sites.
European Journal of PharmacologyAntagonism of the effects of the hallucinogen dom and the purported 5-HT agonist quipazine by 5-HT2 antagonists
186 Citations1983Richard A. Glennon, Richard Young +1 more
The results of this study suggest that the discriminative stimulus effects of DOM, the three hallucinogenic agents to which DOM-stimulus generalization occurred, and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e. 5-HT2 sites).
Biochemical Society TransactionsBiology of Serotonergic Transmission
183 Citations1983Peter F. T. Vaughan
Life SciencesDiscriminative stimulus properties of the serotonin agonist 1-(3-trifluoromethylphenyl) piperazine (TFMPP)
47 Citations1984Richard A. Glennon, J.D. McKenney +1 more
The results of the present study suggest that the discriminative stimulus effects of TFMPP may involve a 5-HT1-related mechanism.
Pharmacology Biochemistry and BehaviorMechanistic studies on DOM as a discriminative stimulus
40 Citations1985Richard A. Glennon, Amy E. Hauck
The hypothesis that DOM may be producing its stimulus effects via a 5-HT2-related mechanism is supported by the results of a standard two-lever operant procedure, coupled with earlier findings.
Annual reports in medicinal chemistryChapter 1. Biochemical Models for Serotonin Receptors
39 Citations1982John D. McDermed, J.E. Leysen +1 more
Correlation between the activities of compounds in biochemical models and in pharmacological models for serotonin receptors S 2 -receptor-binding sites shows that the binding affinities of serotonin, serotonin-like compounds, and serotonin antagonists are completely compatible with the anticipated features of a serotonin neurotransmitter receptor.
Naunyn-Schmiedeberg s Archives of PharmacologyEffects of mazindol, fenfluramine and chlorimipramine on the 5-hydroxytryptamine uptake and storage mechanisms in rat brain: Similarities and differences
24 Citations1977Michele O. Carruba, Giovanni B. Picotti +2 more
It seems that even a long lasting inhibition of the uptake, such as that induced by mazindol, is not sufficient, per se, to cause depletion of brain 5-HT.
Molecular Pharmacology[3H]tetrahydrotrazodone binding. Association with serotonin binding sites.
13 Citations1983Dave Kendal, Duncan P. Taylor +1 more
Pharmacological analysis of [3H]THT binding, coupled with brain lesion and drug treatment experiments, revealed that, unlike other antidepressants, [ 3H] THT does not attach to either a biogenic amine transporter or serotonin binding sites, and it would appear that it may be an antagonist ligand for the serotonin binding site.