Lipoprotein(a) Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Mononuclear Cells
Infection and ImmunityPublished 1 May 1998Open access
Mihai G. Netea, Natasja de Bont, Pierre N.M. Demacker, Bart Jan Kullberg, Liesbeth Jacobs, Trees J.G. Verver-Jansen
Citations28
SJR quartileQ1
SJR score1.05
SNIP0.81
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TL;DR
Lipoprotein(a) [Lp(a)] was as potent as low-density lipoproteins (LDL) in inhibiting LPS-stimulated tumor necrosis factor synthesis by human mononuclear cells, suggesting that circulating Lp( a) may be an important factor determining the amplitude of the response to LPS in humans.
Abstract
Lipoproteins can bind lipopolysaccharide (LPS) and decrease LPS-stimulated cytokine production. Lipoprotein(a) [Lp(a)] was as potent as low-density lipoproteins (LDL) in inhibiting LPS-stimulated tumor necrosis factor synthesis by human mononuclear cells. The kinetics of LPS inhibition by Lp(a) was similar to that of LDL. This suggests that circulating Lp(a) may be an important factor determining the amplitude of the response to LPS in humans.
Keywords
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