The Effect of Short Sleep Duration on Coronary Heart Disease Risk is Greatest Among Those with Sleep Disturbance: A Prospective Study from the Whitehall II Cohort
SLEEPPublished 1 June 2010Open access
Tarani Chandola, Jane E. Ferrie, Aleksander Perski, Tasnime Akbaraly, Michael Marmot
Citations285
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The effect of short sleep (< or = 6 hours) on increasing CHD risk is greatest among those who reported some sleep disturbance, however, among participants who did not report anySleep disturbance, there was little evidence that short sleep hours increasedCHD risk.
Abstract
The effect of short sleep (< or = 6 hours) on increasing CHD risk is greatest among those who reported some sleep disturbance. However, among participants who did not report any sleep disturbance, there was little evidence that short sleep hours increased CHD risk.
Keywords
PsychologyNeuroscience
The LancetImpact of sleep debt on metabolic and endocrine function
3,657 Citations1999Karine Spiegel, Rachel Leproult +1 more
Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
SLEEPMeta-Analysis of Quantitative Sleep Parameters From Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan
3,213 Citations2004Maurice M. Ohayon, Mary A. Carskadon +2 more
In adults, it appeared that sleep latency, percentages of stage 1 and stage 2 significantly increased with age while percentage of REM sleep decreased, and effect sizes for the different sleep parameters were greatly modified by the quality of subject screening, diminishing or even masking age associations with differentSleep parameters.
Annals of Internal MedicineCardiovascular Survey Methods.
3,072 Citations1968Geoffrey Rose, H Blackburn
Archives of General PsychiatryMortality Associated With Sleep Duration and Insomnia
1,609 Citations2002Daniel F. Kripke, Lawrence Garfinkel +3 more
Patients can be reassured that short sleep and insomnia seem associated with little risk distinct from comorbidities, and Slight risks associated with 8 or more hours of sleep and sleeping pill use need further study.
HypertensionShort Sleep Duration as a Risk Factor for Hypertension
1,250 Citations2006James E. Gangwisch, Steven B. Heymsfield +7 more
Archives of Internal MedicineA Prospective Study of Sleep Duration and Coronary Heart Disease in Women
1,159 Citations2003Najib Ayas, David P. White +5 more
Short and long self-reported sleep durations are independently associated with a modestly increased risk of coronary events.
The Journal of Clinical Endocrinology & MetabolismSleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia
1,159 Citations2000Alexandros N. Vgontzas, Dimitris A. Papanicolaou +6 more
There is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition.
The Journal of Clinical Endocrinology & MetabolismAdverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
1,051 Citations2004Alexandros N. Vgontzas, E. Zoumakis +5 more
It is concluded that in young men and women, modest sleep loss is associated with significant sleepiness, impairment of psychomotor performance, and increased secretion of proinflammatory cytokines.
JAMAMajor Risk Factors as Antecedents of Fatal and Nonfatal Coronary Heart Disease Events
1,045 Citations2003Philip Greenland
Antecedent major CHD risk factor exposures were very common among those who developed CHD, emphasizing the importance of considering all major risk factors in determiningCHD risk estimation and in attempting to prevent clinical CHD.
Diabetes CareSleep Duration as a Risk Factor for the Development of Type 2 Diabetes
790 Citations2006H. Klar Yaggi, Andre B. Araujo +1 more
Short and long sleep durations increase the risk of developing diabetes, independent of confounding factors, and sleep duration may represent a novel risk factor for diabetes.
International Journal of EpidemiologyCohort Profile: The Whitehall II study
788 Citations2004Michael Marmot, Eric J. Brunner
The Whitehall II study is set up, a new longitudinal study of British civil servants, with the explicit intention of examining reasons for the social gradient in health and disease in men and extending the research to include women.
Progress in Cardiovascular DiseasesCardiovascular, Inflammatory, and Metabolic Consequences of Sleep Deprivation
772 Citations2008Janet Mullington, Monika Haack +3 more
Findings show that insufficient sleep alters established cardiovascular risk factors in a direction that is known to increase the risk of cardiac morbidity in healthy individuals who normally sleep in the range of 7 to 8 hours and have no sleep disorders.
SLEEPA Prospective Study of Sleep Duration and Mortality Risk in Women
663 Citations2004Sanjay R. Patel, Najib Ayas +6 more
Findings confirm previous findings that mortality risk in women is lowest among those sleeping 6 to 7 hours, and further research is needed to understand the mechanisms by which short and long sleep times can affect health.
Sleep Medicine ReviewsSleep apnea is a manifestation of the metabolic syndrome
557 Citations2005Alexandros N. Vgontzas, Edward O. Bixler +1 more
Accumulating evidence provides support to the model of the bi-directional, feed forward, pernicious association between sleep apnea, sleepiness, inflammation, and insulin resistance, all promoting atherosclerosis and cardiovascular disease.
SLEEPA Prospective Study of Change in Sleep Duration: Associations with Mortality in the Whitehall II Cohort
533 Citations2007Jane E. Ferrie, Martin J. Shipley +5 more
This is the first study to show that both a decrease in sleepduration and an increase in sleep duration are associated with an increaseIn mortality via effects on cardiovascular death and non-cardiovascular death respectively.
Annals of EpidemiologyTest for Additive Interaction in Proportional Hazards Models
510 Citations2007Rongling Li, Lloyd E. Chambless
The simulation study indicates that RERI is the best choice of measures of additivity using a proportional hazards model, and the method has broader application for any regression models with a rate as the dependent variable.
Journal of Internal MedicineSleep complaints predict coronary artery disease mortality in males: a 12‐year follow‐up study of a middle‐aged Swedish population
499 Citations2002Lena Mallon, Jan‐Erik Broman +1 more
It is shown that sleep complaints predict coronary artery disease mortality in males in a middle‐aged Swedish population over a 12-year follow-up study.
Sleep MedicineSleep duration and mortality: the effect of short or long sleep duration on cardiovascular and all-cause mortality in working men and women
336 Citations2002Pauline Heslop, George Davey Smith +3 more
Short sleep over a prolonged period may be associated with an increased risk of mortality: men and women who reported sleeping fewer than 7 h in 24 on two occasions between 4 and 7 years apart, had greater risk of dying from any cause over a 25 year period.
Current Problems in CardiologySleep and Cardiovascular Disease
325 Citations2005Robert Wołk, Apoor S. Gami +2 more
Empirical and pathophysiological studies indicate that there may be a causal link between primary sleep abnormalities and cardiovascular and metabolic disease, such as hypertension, atherosclerosis, stroke, heart failure, cardiac arrhythmias, sudden death, obesity, and the metabolic syndrome.
SLEEPSleep Duration and Sleep Complaints and Risk of Myocardial Infarction in Middle-aged Men and Women from the General Population: The MONICA/KORA Augsburg Cohort Study
303 Citations2007Christa Meisinger, Margit Heier +3 more
Modest associations between short sleep duration and difficulties maintaining sleep and incident MI were seen in middle-aged women but not men from the general population.
American Journal of Physiology-Heart and Circulatory PhysiologySleep and circadian influences on cardiac autonomic nervous system activity
279 Citations1997Helen J. Burgess, John Trinder +2 more
The findings indicate that parasympathetic nervous system activity is mostly influenced by the circadian system, whereas sympathetic nervous systemActivity is mostly influence by the sleep system.
Journal of Internal MedicineSleep as restitution: an introduction
272 Citations2003Torbjörn Åkerstedt, Peter M. Nilsson
Biological PsychologyImpaired sleep after bedtime stress and worries
253 Citations2007Torbjörn Åkerstedt, Göran Kecklund +1 more
It was concluded that moderate increases in stress/worries at bedtime are associated with moderately impaired sleep and mean daytime stress ratings were significantly higher on the day preceding and following the high stress/Worries sleep.
Brain Behavior and ImmunitySelf-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: Evidence for gender disparity
251 Citations2008Edward C. Suarez
The data suggest that subjective ratings of poor sleep, greater frequency of sleep-related symptoms, and longer period of time to fall asleep are associated with a mosaic of biobehavioral mechanisms in women and that these gender-specific associations have direct implications to recent observations suggesting gender differences in the association between symptoms of poorSleep and cardiovascular disease.
Clinical Psychology ReviewCognitive approaches to insomnia
244 Citations2005Allison G. Harvey, Nicole K. Y. Tang +1 more
There is evidence that a broad range of cognitive processes are important for a full understanding of insomnia, including beliefs, attributions, expectations, perception and attention.
Scandinavian Journal of Work Environment & HealthDisturbed sleep and fatigue in occupational burnout
227 Citations2006Mirjam Ekstedt, Marie Söderström +4 more
Investigating sleep with polysomnography and self-ratings and the diurnal pattern of sleepiness and fatigue in a group suffering from severe occupational burnout found impaired sleep may play a role in the development of fatigue or exhaustion in burnout.
Psychosomatic MedicineMicroarousals During Sleep Are Associated With Increased Levels of Lipids, Cortisol, and Blood Pressure
224 Citations2004Mirjam Ekstedt, Torbjörn Åkerstedt +1 more
Sleep fragmentation was associated with elevated levels of metabolic and cardiovascular risk indicators of stress-related disorders, and number of arousals also seems to be related to workload/stress.
ThoraxSleep {middle dot} 1: Obstructive sleep apnoea/hypopnoea syndrome: definitions, epidemiology, and natural history
220 Citations2003John Stradling
New approaches are needed to identify those who have “CPAP responsive” disease, enabling more accurate estimates to be made of the prevalence of the sleep apnoea syndrome in the community.
American Journal of EpidemiologyCross-sectional versus Prospective Associations of Sleep Duration with Changes in Relative Weight and Body Fat Distribution
195 Citations2007Saverio Stranges, Francesco P. Cappuccio +8 more
There is no temporal relation between short duration of sleep and future changes in measures of body weight and central adiposity and the Whitehall II Study found that this has not been confirmed prospectively.
Journal of EpidemiologySleep Duration and Mortality in Japan: the Jichi Medical School Cohort Study
176 Citations2004Yoko Amagai, Shizukiyo Ishikawa +5 more
The data suggest that males with short sleep and females with long sleep were at an elevated risk of death.
StrokeExcessive Daytime Sleepiness Is an Independent Risk Indicator for Cardiovascular Mortality in Community-Dwelling Elderly
169 Citations2009Jean‐Philippe Empana, Yves Dauvilliers +8 more
EDS might be independently associated with total and cardiovascular mortality in community-dwelling elderly and was equally predictive of mortality in those who snored loudly and in Those who did not.
PubMedSleep measurement in flight crew: comparing actigraphic and subjective estimates to polysomnography.
162 Citations2005T. Leigh Signal, Jesse Gale +1 more
Findings indicate that the performance of the actigraph is not altered in flight, other than the predictable effects associated with shorter, more disturbed sleep.
SLEEPThe Parable of Parabola: What the U-Shaped Curve Can and Cannot Tell Us about Sleep
113 Citations2007Donald L. Bliwise, Terry Young
Noteworthy in the Hublin et al and Ferrie et al studies is that participants were queried about their sleep durations at two different time points separated by intervals of 5 to 6 years, and mortality was assessed 22 and 12 years, respectively, subsequent to the second measurement.
Psychosomatic MedicinePsychological Distress as a Predictor of CHD Events in Men: The Effect of Persistence and Components of Risk
74 Citations2005Amanda Nicholson, Rebecca Fuhrer +1 more
Postgraduate MedicineGender Differences in Coronary Artery Disease: Review of Diagnostic Challenges and Current Treatment
24 Citations2009Prabhakaran Gopalakrishnan, Moluk Mirrasouli Ragland +1 more
Physicians have to be acutely aware of gender bias and gender-based differences in clinical presentation, accuracy of diagnostic tests, and clinical outcomes.
Clinical CardiologyPreventing Cardiovascular Disease in Women: An Update
17 Citations2007Nanette K. Wenger
Somnologie - Schlafforschung und SchlafmedizinSubjective and objective quality of sleep
9 Citations2008Torbjörn Åkerstedt, Göran Kecklund +1 more
Stress, Sleep and Restitution
4 Citations2006Torbjörn Åkerstedt
Subjective and objectiv quality of sleep
2 Citations2008Torbjörn Åkerstedt, Göran Kecklund +1 more
A group of 33 subjects who had sleep polysomnographically recorded in their homes for three nights during a period of several weeks were used and it was suggested that the differing results may have been due to the large age span confusing SWS/quality correlations.
