Reactome: a knowledge base of biologic pathways and processes
Genome biologyPublished 16 March 2007Open access
Imre Västrik, Peter D’Eustachio, Esther Schmidt, Joshi-Tope Geeta, Gopal Gopinath, David Croft
Citations661
SJR quartileQ1
SJR score5.71
SNIP2.21
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TL;DR
This work uses Reactome to infer equivalent reactions in multiple nonhuman species, and presents data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae.
Abstract
Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.
Keywords
Biochemistry, Genetics and Molecular Biology
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