Effects of age and body lead burden on CNS function in young children. I. Slow cortical potentials
Electroencephalography and Clinical NeurophysiologyPublished 1 October 1981
David A. Otto, Vernon A. Benignus, Keith E. Muller, Curtis N. Barton
Citations79
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TL;DR
Evidence is provided of altered CNS function at the lowest Pb effect level ever reported and the effects of body Pb burden on slow cortical potentials were studied in children aged 13-75 months.
Abstract
The effects of body Pb burden on slow cortical potentials were studied in 63 children aged 13-75 months. Slow wave (SW) voltage during sensory conditioning varied as a linear function of blood lead (PbB) level. The slope of this function, moreover, changed systematically with age. For children under 5 years of age, SW voltage tended to be positive at low PbBs and to be negative above 30 micrograms/dl. For children over 5 years of age, SW voltage tended to be negative at low PbBs and to be less negative (or positive) above 30 micrograms/dl. These results provide evidence of altered CNS function at the lowest Pb effect level ever reported.
Keywords
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