MRI-PET Registration with Automated Algorithm
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TL;DR
Modifications to this method that allow for cross-modality registration of MRI and PET brain images obtained from a single subject are described and validated quantitatively using data from patients with stereotaxic fiducial markers rigidly fixed in the skull.
Abstract
The method has been validated quantitatively using data from patients with stereotaxic fiducial markers rigidly fixed in the skull. Maximal three-dimensional errors of < 3 mm and mean three-dimensional errors of < 2 mm were measured. Computation time on a SPARCstation IPX varies from 3 to 9 min to align MR image sets with [18F]fluorodeoxyglucose PET images. The MR alignment with noisy H2(15)O PET images typically requires 20-30 min.
