Clinical characteristics of Crohn's disease in 72 families
GastroenterologyPublished 1 September 1996Open access
J F Colombel, Bruno Grandbastien, Corinne Gower‐Rousseau, S Plegat, J P Evrard, Dupas Jl
Citations179
SJR quartileQ1
SJR score7.20
SNIP5.04
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TL;DR
Patients with familial Crohn's disease are characterized by an early age at onset with more extensive disease and may represent a homogeneous clinical subgroup with a particularly strong genetic influence.
Abstract
Patients with familial Crohn's disease are characterized by an early age at onset with more extensive disease and may represent a homogeneous clinical subgroup with a particularly strong genetic influence.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
PubMedFamilial Crohn's disease in multiple siblings: no linkage to the HLA system.
15 Citations1989Jean–Frédéric Colombel, F Guillemot +5 more
HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease, however similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.