Evidence for dopamine receptor stimulation by apomorphine
Journal of Pharmacy and PharmacologyPublished 1 September 1967
Nils‐Erik Andén, A. Rubenson, Kjell Fuxé, Tomas Hökfelt
Citations913
SJR quartileQ2
SJR score0.72
SNIP0.73
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Supporting evidence for apomorphine acts on the dopamine receptors whereas amphetamine acts by releasing dopamine is given by further functional, biochemical and histochemical studies.
Abstract
Nils-Erik Andén, Allan Rubenson, Kjell Fuxe, Tomas Hökfelt; Evidence for dopamine receptor stimulation by apomorphine, Journal of Pharmacy and Pharmacology
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
Journal of Histochemistry & CytochemistryFLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE
2,709 Citations1962B. Falck, N.‐Å. Hillarp +2 more
Acta Physiologica ScandinavicaA Method for the Fluorimetric Determination of Adrenaline and Noradrenaline in Tissues.<sup>1</sup>
1,031 Citations1958Åke Bertler, Arvid Carlsson +1 more
A method for chemical assay of small amounts of adrenaline and noradrenaline in tissues is described, utilizing the difference in the activation spectra of the fluoro-phores to identify the two amines.
PsychopharmacologyMode of action of apomorphine and dexamphetamine on gnawing compulsion in rats
909 Citations1967A. M. Ernst
The action of apomorphine on gnaw compulsion is, just as that of dopamine, directly on effect receptors, and may act as a substitute for dopamine deficiency in Parkinson's disease.
Journal of Pharmacology and Experimental TherapeuticsANTIAMPHETAMINE EFFECTS FOLLOWING INHIBITION OF TYROSINE HYDROXYLASE
452 Citations1966Albert Weissman, B. Kenneth Koe +1 more
The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects.
Life SciencesEffects of tyrosine hydroxylase inhibition on the amine levels of central monoamine neurons
202 Citations1966Nils‐Erik Andén, H. Corrodi +3 more
The methyl ester of α-methyl- p -tyrosine, an inhibitor of the tyrosine hydroxylase, causes the catecholamines but not the 5-hydroxytryptamine in rat brain and spinal cord to disappear almost completely in 24 hours.
PsychopharmacologyEvidence that the central action of (+)-amphetamine is mediated via catecholamines
157 Citations1967Lennart C. F. Hanson
The data support the view that (+)- methamphetamine for its central action requires the presence of catecholamines in low concentrations, and presumably (+)-amphetamine acts by releasing catechlamines from nerve terminals in the brain.