Clinical severity of Alzheimer's disease is associated with PIB uptake in PET
Neurobiology of AgingPublished 19 March 2008
Timo Grimmer, Gjermund Henriksen, Hans‐Jürgen Wester, Hans Förstl, William E. Klunk, Chester A. Mathis
Citations92
SJR quartileQ1
SJR score1.45
SNIP0.92
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD, and is a potential surrogate marker of dementia severity.
Abstract
The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD. Thus [11C]PIB is a potential surrogate marker of dementia severity.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Journal of Psychiatric Research“Mini-mental state”
86,858 Citations1975Marshal F. Folstein, Susan E. Folstein +1 more
A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
NeurologyClinical diagnosis of Alzheimer's disease
27,993 Citations1984Guy M. McKhann, David A. Drachman +4 more
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
NeuroImageAutomated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain
16,817 Citations2002N. Tzourio-Mazoyer, Brigitte Landeau +6 more
An anatomical parcellation of the spatially normalized single-subject high-resolution T1 volume provided by the Montreal Neurological Institute was performed and it is believed that this tool is an improvement for the macroscopical labeling of activated area compared to labeling assessed using the Talairach atlas brain.
ScienceThe Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
13,830 Citations2002John Hardy, Dennis J. Selkoe
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue, and accumulation of Aβ in the brain is the primary influence driving AD pathogenesis.
Human Brain MappingStatistical parametric maps in functional imaging: A general linear approach
9,813 Citations1994Karl Friston, Andrew P. Holmes +4 more
NeurologyVascular dementia
4,855 Citations1993Gustavo C. Román, T. K. Tatemichi +29 more
These criteria for the diagnosis of vascular dementia are intended as a guide for case definition in neuroepidemiologic studies, stratified by levels of certainty (definite, probable, and possible).
Annals of NeurologyImaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
4,477 Citations2004William E. Klunk, Henry Engler +19 more
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
NeurologyThe Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease
4,050 Citations1989J. C. Moms, Albert Heyman +6 more
Although information on validation is limited thus far, the CERAD batteries appear to fill a need for a standardized, easily administered, and reliable instrument for evaluating persons with AD in multicenter research studies as well as in clinical practice.
NeurologyPhases of Aβ-deposition in the human brain and its relevance for the development of AD
3,345 Citations2002Dietmar Rudolf Thal, Udo Rüb +2 more
Aβ-deposition in the entire brain follows a distinct sequence in which the regions are hierarchically involved and expands anterogradely into regions that receive neuronal projections from regions already exhibiting Aβ.
NeurologyClinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
1,312 Citations2005S. Gilman, M. Köller +9 more
This phase IIa immunotherapy trial of AN1792(QS-21) in patients with mild to moderate Alzheimer disease (AD) that was interrupted because of meningoencephalitis provides an indication that Aβ immunotherapy may be useful in Alzheimer disease.
JAMACorrelation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
1,263 Citations2000Jan Näslund
An important role for Abeta in mediating initial pathogenic events in AD dementia is supported and treatment strategies targeting the formation, accumulation, or cytotoxic effects of Abeta should be pursued.
NeurologyImaging β-amyloid burden in aging and dementia
1,099 Citations2007C. C. Rowe, Sally Ng +18 more
Pittsburgh Compound B PET findings match histopathologic reports of β-amyloid (Aβ) distribution in aging and dementia, and suggest that Aβ may influence the development of dementia with Lewy bodies, and therefore strategies to reduce A β may benefit this condition.
Molecular ImagingAMIDE: A Free Software Tool for Multimodality Medical Image Analysis
977 Citations2003Andreas M. Loening, Sanjiv S. Gambhir
Amide's a Medical Image Data Examiner (AMIDE) has been developed as a user-friendly, open-source software tool for displaying and analyzing multimodality volumetric medical images and on-demand data reslicing implemented within the program.
Journal of Cerebral Blood Flow & MetabolismThe Relationship between Global and Local Changes in PET Scans
864 Citations1990Karl Friston, Chris Frith +4 more
American Journal of Geriatric PsychiatryLocalization of Neurofibrillary Tangles and Beta-Amyloid Plaques in the Brains of Living Patients With Alzheimer Disease
764 Citations2002Kooresh I. Shoghi, Gary W. Small +9 more
This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments.
Neurobiology of AgingPET imaging of amyloid deposition in patients with mild cognitive impairment
724 Citations2007Anton Forsberg, Henry Engler +7 more
Correlations were observed in the MCI patients between PIB retention and CSF Abeta(1-42), total Tau and episodic memory, respectively, and the P IB retention in MCI converters was comparable to AD patients.
BrainTwo-year follow-up of amyloid deposition in patients with Alzheimer's disease
609 Citations2006Henry Engler, Anton Forsberg +8 more
Relatively stable PIB retention after 2 years of follow-up in patients with mild Alzheimer's disease suggests that amyloid deposition in the brain reaches a plateau by the early clinical stages of Alzheimer’s disease and therefore may precede a decline in rCMRGlc and cognition.
PubMedSimplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.
541 Citations2005Brian J. Lopresti, William E. Klunk +9 more
Of the simplified methods for PIB analysis examined, CAR90 provided DVR measures that were most comparable to ART90; CER90 was the most reproducible and SUVR90 produced the largest effect size.
NeurologyThe importance of neuritic plaques and tangles to the development and evolution of AD
482 Citations2004Pietro Tiraboschi, Lawrence A. Hansen +2 more
The significant increase in neuritic plaques, but not neurofibrillary tangles, in patients with even mild Alzheimer disease at death compared with normal control subjects suggests that only neuritic Plaques are associated with the earliest symptoms of Alzheimer disease.
NeurologyEvaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD
351 Citations2005Antony Bayer, R. Morris Bullock +6 more
AN1792 + QS-21 elicited a positive antibody response to Aβ42 in more than half of this elderly study population, and Disability Assessment for Dementia scores showed less decline among active compared with control patients at week 84 (p = 0.002).
Neurobiology of Agingβ-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
305 Citations1996B. Cummings, Christian J. Pike +2 more
Interestingly, it was found that most pathologic measures correlated highly with the severity of dementia, however, the strongest predictor of premortem cognitive dysfunction on all three cognitive measures was the relative area of entorhinal cortex occupied by beta-amyloid deposition.
BrainPIB is a non-specific imaging marker of amyloid-beta (A ) peptide-related cerebral amyloidosis
304 Citations2007Andrew Lockhart, Janette Lamb +7 more
The data provide a molecular explanation for PIB's limited specificity in diagnosing and monitoring disease progression in AD and instead indicate that the ligand is primarily a non-specific marker of Abeta-peptide related cerebral amyloidosis.
Archives of NeurologyRegional Distribution of Neuritic Plaques in the Nondemented Elderly and Subjects With Very Mild Alzheimer Disease
287 Citations1998Vahram Haroutunian
Findings are consistent with the hypothesis that NPs are among the earliest neuropathological lesions in AD, and even very mild or questionable dementia is associated with increased density of neocortical NPs that do not distinguish between clinically questionable vs definite dementia.
NeuroImageImaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer’s disease
204 Citations2007Alexander Drzezga, Timo Grimmer +8 more
Amyloid plaque PET may complement neuropsychological assessment regarding reliable differential diagnosis of AD and FTLD dementias based on characterization of underlying pathology and may improve the definition of individual prognosis and the selection of patients for scientific trials.
Neurobiology of AgingAge-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Aβ levels
163 Citations2006Ewa Hellström‐Lindahl, R. Ravid +1 more
The findings of an inverse correlation between neprilysin and insoluble A beta levels in both groups suggest that nerilysin is involved in the clearance of A beta.
Clinical ChemistryImproved Method for Genotyping Apolipoprotein E Polymorphisms by a PCR-Based Assay Simultaneously Utilizing Two Distinct Restriction Enzymes
161 Citations1997Ariella Zivelin, Nurit Rosenberg +4 more
A simple procedure is described that facilitates the genotyping of the apo E polymorphisms, which are associated with increased total serum cholesterol and greater odds for coronary heart disease and Alzheimer disease.
NeurologyDissociation of neuropathology from severity of dementia in late-onset Alzheimer disease
131 Citations2006I. Prohovnik, Daniel P. Perl +4 more
The nature or expression of Alzheimer disease may be different in severely demented older patients, who have equal cholinergic deficits but significantly lower plaque and tangle burden.
PubMedIntra- and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease.
122 Citations2004P. Fernández‐Vizarra, Ana Patricia Fernández +6 more
It is suggested that the intracellular Abeta deposition in cortical pyramidal neurons is a first neurodegenerative event in AD development and that it is involved in cell dysfunction, neuronal death, and plaque formation.
NeuroImageEvaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
119 Citations2006Scott K. Ziolko, Lisa A. Weissfeld +6 more
The results of the present study indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment.
Dementia and Geriatric Cognitive DisordersRegion-Specific Decline of Cerebral Glucose Metabolism in Patients with Frontotemporal Dementia: A Prospective <sup>18</sup>F-FDG-PET Study
78 Citations2004Timo Grimmer, Janine Diehl +3 more
Compared with normal controls, FTD patients showed significant metabolic deficits primarily in frontal cortical areas, but also in the caudate nuclei and the thalami.
Journal of Neuropathology & Experimental NeurologyClinical Validity of Aß-Protein Deposition Staging in Brain Aging and Alzheimer Disease
69 Citations2001Gabriel Gold, Enikò Kövari +7 more
The data support the close relationship between NFT progression and amyloid formation within the medial temporal lobe proposed by Braak's group but demonstrate the limited value of Abeta-protein deposition staging in terms of clinicopathological correlations.
Neuroimaging Clinics of North AmericaImaging Alzheimer's disease: clinical applications
69 Citations2003Satoshi Minoshima
Evidence for the efficacy of PET imaging through well-organized clinical studies, as well as continuing efforts in technologic development and basic research to characterize functional alterations in dementing disorders in living patients, are equally important to achieve the goal of better dementia care.
Journal of Neuropathology & Experimental NeurologyNeuropathologic Criteria for Diagnosing Alzheimer Disease in Persons with Pure Dementia of Alzheimer Type
68 Citations2004Daniel W. McKeel, Joseph L. Price +5 more
Test the hypothesis that Bielschowsky silver stained total, cored, and neuritic senile plaques, rather than neurofibrillary tangles, best discriminate between the 2 conditions using rigorously defined nondemented and AD subjects with no known co-morbidities.
