Potential Biohazards of Recombinant DNA Molecules
SciencePublished 26 July 1974
Paul Berg, David Baltimore, Herbert W. Boyer, Stanley N. Cohen, Ronald W. Davis, David S. Hogness
Citations392
SJR quartileQ1
SJR score10.42
SNIP6.62
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This paper presents a meta-analyses of the determinants of infectious disease in eight operation rooms of the immune system and shows clear patterns in response to antibiotics and in particular the presence of E.coli.
Abstract
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Keywords
Biochemistry, Genetics and Molecular BiologyChemical Engineering
Proceedings of the National Academy of SciencesConstruction of Biologically Functional Bacterial Plasmids <i>In Vitro</i>
1,768 Citations1973Stanley N. Cohen, Annie Chang +2 more
Newly constructed plasmids that are inserted into Escherichia coli by transformation are shown to be biologically functional replicons that possess genetic properties and nucleotide base sequences from both of the parent DNA molecules.
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380 Citations1974John F. Morrow, Stanley N. Cohen +4 more
Fragments of amplified Xenopus laevis DNA, coding for 18S and 28S ribosomal RNA and generated by EcoRI restriction endonuclease, have been linked in vitro to the bacterial plasmid pSC101; and the recombinant molecular species have been introduced into E. coli by transformation.
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182 Citations1974Annie Chang, Stanley N. Cohen
Genes carried by EcoRI endonuclease-generated fragments of Staphylococcus plasmid DNA have been covalently joined to the E. coli antibiotic-resistance plasmids pSC101, and the resulting hybrid molecules have been introduced into E. bacteria by transformation.