Loneliness and Risk of Alzheimer Disease
Archives of General PsychiatryPublished 1 February 2007
Robert S. Wilson, Kristin R. Krueger, Steven E. Arnold, Julie A. Schneider, Jeremiah F. Kelly, Lisa L. Barnes
Citations1,330
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TL;DR
Loneliness is associated with an increased risk of late-life dementia but not with its leading causes, and was robustly associated with cognitive decline and development of AD.
Abstract
Loneliness is associated with an increased risk of late-life dementia but not with its leading causes.
Keywords
PsychologySocial SciencesMedicine
NeurologyClinical diagnosis of Alzheimer's disease
27,993 Citations1984Guy M. McKhann, David A. Drachman +4 more
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
BiometrikaLongitudinal data analysis using generalized linear models
18,123 Citations1986Kung‐Yee Liang, Scott L. Zeger
PubMedSTUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.
12,208 Citations1963Sidney Katz, A B FORD +3 more
BiometricsRandom-Effects Models for Longitudinal Data
8,915 Citations1982Nan M. Laird, James H. Ware
A unified approach to fitting these models, based on a combination of empirical Bayes and maximum likelihood estimation of model parameters and using the EM algorithm, is discussed.
Journal of Personality AssessmentUCLA Loneliness Scale (Version 3): Reliability, Validity, and Factor Structure
5,691 Citations1996Daniel W. Russell
The psychometric properties of the UCLA Loneliness Scale (Version 3) were evaluated and it was indicated that the measure was highly reliable, both in terms of internal consistency and test-retest reliability over a 1-year period.
Journal of Personality and Social PsychologyThe revised UCLA Loneliness Scale: Concurrent and discriminant validity evidence.
3,604 Citations1980Daniel W. Russell, Letitia Anne Peplau +1 more
Two studies provide methodological refinement in the measurement of loneliness, demonstrating that although loneliness is correlated with measures of negative affect, social risk taking, and affiliative tendencies, it is nonetheless a distinct psychological experience.
Journal of Aging and HealthTwo Shorter Forms of the CES-D Depression Symptoms Index
2,298 Citations1993Frank J. Kohout, Lisa Berkman +2 more
Psychology and AgingLoneliness as a specific risk factor for depressive symptoms: Cross-sectional and longitudinal analyses.
2,293 Citations2006John T. Cacioppo, Mary Elizabeth Hughes +3 more
It is suggested that loneliness and depressive symptomatology can act in a synergistic effect to diminish well-being in middle-aged and older adults.
Archives of NeurologyPhysical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons
1,554 Citations2001Danielle Laurin, René Verreault +3 more
Regular physical activity could represent an important and potent protective factor for cognitive decline and dementia in elderly persons.
Archives of NeurologyThe Clinical Diagnosis of Alzheimer's Disease
1,380 Citations1987John Wade, Thomas Mirsen +4 more
The sensitivity of diagnosis for dementia of the Alzheimer type (DAT) without any other diagnosis was 87%, and the specificity was 78%, but the ischemic scale score did not discriminate well between patients with pure multi-infarct dementia and those with both DAT and multi- infarCT dementia.
NeurologyNeuropathology of older persons without cognitive impairment from two community-based studies
1,356 Citations2006David A. Bennett, Julie A. Schneider +5 more
Alzheimer disease pathology can be found in the brains of older persons without dementia or mild cognitive impairment and is related to subtle changes in episodic memory.
The LancetInfluence of social network on occurrence of dementia: a community-based longitudinal study
1,341 Citations2000Laura Fratiglioni, Hui‐Xin Wang +3 more
An extensive social network seems to protect against dementia, and further investigation to clarify the mechanisms are worthwhile due to the implications for prevention.
JAMAParticipation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease
1,315 Citations2002Robert S. Wilson
Results suggest that frequent participation in cognitively stimulating activities is associated with reduced risk of AD.
Applied Psychological MeasurementThe Development of a Rasch-Type Loneliness Scale
1,282 Citations1985J. de Jong-Gierveld, Frans Kamphuls
Annals of Internal MedicineSocial Disengagement and Incident Cognitive Decline in Community-Dwelling Elderly Persons
973 Citations1999Shari S. Bassuk, Thomas A. Glass +1 more
Whether a global measure of social disengagement was associated with incident cognitive impairment in a large cohort of community-dwelling elderly persons followed for 12 years is determined.
American Journal of EpidemiologyLate-Life Engagement in Social and Leisure Activities Is Associated with a Decreased Risk of Dementia: A Longitudinal Study from the Kungsholmen Project
960 Citations2002Hui‐Xin Wang
Results suggest that stimulating activity, either mentally or socially oriented, may protect against dementia, indicating that both social interaction and intellectual stimulation may be relevant to preserving mental functioning in the elderly.
Psychology and AgingIndividual differences in rates of change in cognitive abilities of older persons.
828 Citations2002Robert S. Wilson, Laurel Beckett +5 more
The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process.
NeurologyInfluence of leisure activity on the incidence of Alzheimer’s Disease
822 Citations2001Nikolaos Scarmeas, Gilberto Levy +3 more
The data suggest that engagement in leisure activities may reduce the risk of incident dementia, possibly by providing a reserve that delays the onset of clinical manifestations of the disease.
Health PsychologySocial relationships, social support, and patterns of cognitive aging in healthy, high-functioning older adults: MacArthur Studies of Successful Aging.
802 Citations2001Teresa E. Seeman, Tina M. Lusignolo +2 more
Examination of the relationship of social ties and support to patterns of cognitive aging in the MacArthur Studies of Successful Aging suggests the potential value of further research on the role of the social environment in protecting against cognitive declines at older ages.
Journal of Personality and Social PsychologyLoneliness in everyday life: Cardiovascular activity, psychosocial context, and health behaviors.
587 Citations2003Louise C. Hawkley, Mary H. Burleson +2 more
Loneliness did not predict differences in time spent alone, daily activities, or health behaviors but did predict higher stress appraisals and poorer social interactions, and interaction quality contributed to TPR.
The Journals of Gerontology Series APredictors of Cognitive Decline and Mortality of Aged People Over a 10-Year Period
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The strongest predictors of both cognitive decline and mortality are age, APOE4, manifest vascular diseases, and diabetes, and the role of new potential predictors, feelings of loneliness and hypercalcemia, needs clinical testing.
NeurologySocial resources and cognitive decline in a population of older African Americans and whites
575 Citations2004Lisa L. Barnes, Carlos F. Mendes de Leon +3 more
Greater social resources, as defined by social networks and social engagement, are associated with reduced cognitive decline in old age.
Journal of Personality and Social PsychologyDeveloping and testing a model of loneliness.
465 Citations1987J. de Jong-Gierveld
A model of loneliness that incorporates characteristics of the social network, background variables, personality characteristics, and evaluative aspects is presented that is able to disentangle both the direct and the indirect causal influences of the various factors on loneliness.
Preventive MedicineSocial Relations, Physical Activity, and Well-Being in Older Adults
456 Citations2000Edward McAuley, Bryan Blissmer +4 more
It appears that social relations integral to the exercise environment are significant determinants of subjective well-being in older adults.
American Journal of EpidemiologySocial Engagement and Disability in a Community Population of Older Adults: The New Haven EPESE
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A strong, but not necessarily causal association of social engagement with disability is found, with more socially engaged older adults reporting less disability, and Promotion ofsocial engagement may still be important for the prevention of disability.
Journal of GerontologyEstablished Populations for Epidemiologic Studies of the Elderly: Resource Data Book
422 Citations1987George A. Kaplan
Journal of the American Geriatrics SocietySocial and Leisure Activities and Risk of Dementia: A Prospective Longitudinal Study
416 Citations1995Colette Fabrigoule, Luc Letenneur +4 more
This research aims to study the relationship between social and leisure activities and risk of subsequent dementia in older community residents and the role of leisure activities in this risk.
NeuroepidemiologyThe Rush Memory and Aging Project: Study Design and Baseline Characteristics of the Study Cohort
415 Citations2005David A. Bennett, Julie A. Schneider +4 more
The long-term objective of the Rush Memory and Aging Project is to identify the postmortem indices linking genetic and environmental risk factors to the development of Alzheimer’s disease.
Journal of the International Neuropsychological SocietyEarly and late life cognitive activity and cognitive systems in old age
347 Citations2005Robert S. Wilson, Lisa L. Barnes +4 more
Past cognitive activity contributes to current cognition principally through its association with cognitive activity in old age, and current cognitive activity was associated with better cognitive function, especially semantic memory and perceptual speed, even after controlling for past activity.
Brain ResearchDecreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats
338 Citations2003Adriana Berenice Silva Gómez, Darı x o Rojas +2 more
The present results suggest that pwSI may in part affect the dendritic morphology in the limbic structures such as mPFC and hippocampus that are implicated in schizophrenia.
NeurologyRelation of cerebral infarctions to dementia and cognitive function in older persons
306 Citations2003Julie A. Schneider, R. J. Wilson +5 more
Cerebral infarctions are associated with a twofold increase in odds of dementia, and odds are higher in persons with multiple, large, or clinically evident infarction.
Psychology Press eBooksAssessment of lifetime participation in cognitively stimulating activities
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The data suggest that hippocampal-dependent memory impairments induced by elevated levels of brain IL-1beta may occur via an IL- 1beta-induced downregulation in hippocampal BDNF.
PubMedDepressive symptoms and cognitive decline in a community population of older persons.
243 Citations2004R. J. Wilson, Carlos F. Mendes de Leon +3 more
The results suggest that depressive symptoms predict cognitive decline in old age in a biracial community of older persons.
Journal of Personality and Social PsychologyLoneliness and social skill deficits.
219 Citations1982Warren H. Jones, Steven A. Hobbs +1 more
The relationship between social skill deficits and the psychological state of loneliness was examined and increased use of partner attention during dyadic interactions resulted in significantly greater change in loneliness and related variables relative to interaction only and no-contact control groups.
Age and AgeingChanges in and factors related to loneliness in older men. The Zutphen Elderly Study
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American Journal of Preventive MedicineExercise Patterns in a Population of Older Adults
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Exercise frequency was lower in those with a history of chronic disease, obesity, or current cigarette smoking, and exercise was positively associated with physical and emotional functioning and self-rated health.
NeurologyMarital status and risk of Alzheimer’s disease
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Psychological MedicineIncidence and relative risk of dementia in an urban elderly population: findings of a prospective field study
174 Citations1994Horst Bickel, Brian Cooper
It is suggested that identification of mild cognitive impairment on screening could prove helpful in assessing risk for dementia from two to three years before the condition becomes clinically apparent.
The Journals of Gerontology Series BTheories on Coping With Loss: The Impact of Social Support and Self-Esteem on Adjustment to Emotional and Social Loneliness Following a Partner's Death in Later Life
164 Citations2002Berna van Baarsen
The role of self-esteem and social support in adjustment to loneliness experienced by bereaved elderly persons and the contributions of a general and a specific coping theory toward explaining loneliness were examined.
American Journal of EpidemiologyNegative Affect and Mortality in Older Persons
157 Citations2003R. J. Wilson
Examination of the relation of negative affect to mortality in the Religious Orders Study suggests that negative affect in older persons, especially internally experienced distress, is associated with an increased mortality risk.
Journal of Advanced NursingLoneliness among elderly people living in Stockholm: a population study
153 Citations1992Kann Holmén, Kjerstin Ericsson +2 more
A high frequency of experienced loneliness was found among elderly people with reduced cognitive function and Subjectively experienced bad health and loneliness were strongly related to each other, i.e a person who experienced loneliness did usually not feel completely healthy.
Behavioural Brain ResearchDouble dissociation of social and environmental stimulation on spatial learning and reversal learning in rats
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On both global and specific measures, rate of cognitive decline was reduced in older persons compared with younger persons and the results suggest that in clinical settings some of this variability is related to age.
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Older age and female sex were independent factors associated with cognitive impairment (CI), and no formal education, slow gait time and institutionalization increased the risk of CI in both sexes.
International Journal of Public Opinion ResearchSTABILITY OF SCALE QUALITY UNDER VARIOUS DATA COLLECTION PROCEDURES: A MODE COMPARISON ON THE ‘DE JONG-GIERVELD LONELINESS SCALE
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