Inhibition of 5-hydroxytryptamine reuptake by amitriptyline and zimelidine and its relationship to their therapeutic action
PsychopharmacologyPublished 1 January 1979
Alec Coppen, V. A. Rama Rao, Cynthia Swade, K. Wood
Citations37
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
The accepted mode of action of tricyclic antidepressant drugs and the deficiency hypotheses of affective disorders are discussed and no significant relationship could be detected between the degree of inhibition of uptake and therapeutic outcome.
Abstract
Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeutic outcome. The accepted mode of action of tricyclic antidepressant drugs and the deficiency hypotheses of affective disorders are discussed.
Keywords
MedicineNeuroscience
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