TNFα induces IL-6 production by astrocytes but not by microglia
Brain ResearchPublished 1 June 1992
Makoto Sawada, Akio Suzumura, Tohru Marunouchi
Citations182
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
The results suggest that different regulatory mechanisms for cytokine production exist in glial cells, and the possible roles of astrocytes and microglia in CNS immune responses are discussed.
Abstract
Astrocytes and microglia, both produced interleukin-6 (IL-6) in culture by lipopolysaccharide (LPS) stimulation. IL-6 activity was detected 3-5 h after LPS stimulation and reached a maximum at 10 h. Microglia responded faster than astrocytes. Tumor necrosis factor alpha and interleukin 1 also induced IL-6 mRNA and biological activity in astrocytes, but not in microglia. Among these stimuli, LPS was the most potent inducer of IL-6 production by astrocytes. Our results suggest that different regulatory mechanisms for cytokine production exist in glial cells. The possible roles of astrocytes and microglia in CNS immune responses are also discussed.
Keywords
Immunology and MicrobiologyNeuroscience
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