Nasopharyngeal carcinoma: Histopathological types and association with Epstein-Barr virus
European Journal of Cancer Part B Oral OncologyPublished 1 April 1993
Ulla Hørding, Henrik Winther Nielsen, Henrik Albeck, Søren Daugaard
Citations32
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TL;DR
The study confirms the infrequent association of keratinising NPC and EBV, in contrast with the 100% association of the less differentiated NPCs and the virus, and may indicate a different carcinogenesis for the WHO 1 NPC subtype.
Abstract
The polymerase chain reaction was used to examine paraffin-embedded tissues of 37 nasopharyngeal carcinomas (NPC) for Epstein-Barr virus (EBV) genomic sequences. EBV DNA was found in 2/14 keratinising squamous cell (WHO 1) carcinomas and in all of 23 non-keratinising and undifferentiated (WHO 2 and 3) NPC. The study confirms the infrequent association of keratinising NPC and EBV, in contrast with the 100% association of the less differentiated NPCs and the virus. The results may indicate a different carcinogenesis for the WHO 1 NPC subtype.
Keywords
Medicine
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