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Treatment of adolescents with major depression: implications of the DST and the melancholic clinical subtype

Journal of Affective DisordersPublished 1 September 1989
Douglas R. Robbins, Norman E. Alessi, Marit V. Colfer
Citations62
SJR quartileQ1
SJR score2.12
SNIP1.65

TL;DR

The melancholic subtype and dexamethasone suppression test non-suppression were associated with failure to respond to psychosocial treatment alone and implications for controlled studies are discussed.

Abstract

Of 38 adolescents hospitalized with major depression, 47% of those receiving psychosocial treatment alone responded. Of the non-responders then treated with combined tricyclic antidepressants and psychosocial treatment, 92% responded. The melancholic subtype and dexamethasone suppression test non-suppression were associated with failure to respond to psychosocial treatment alone. Implications for controlled studies are discussed.

Keywords

PsychologyMedicine